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The complex formation equilibria of [Pd(FLX)(HO)], where FLX = the drug fluoxetine, with the bio-ligands (L), glycine, serine, cysteine, histidine, glycylglycine and glycylvaline, were studied and their formation constants were determined. Stoichiometries and stability constants of the complexes were determined at 25 °C and at constant 0.10 mol·dm NaNO ionic strength. The concentration distribution of the complexes in solution was evaluated. Palladium(II) complexes were synthesized and characterized by the H NMR and electronic spectral studies. The structures consist of monomeric units in which the Pd(II) atoms exhibit square planar geometry. [ABSTRACT FROM AUTHOR]

The article presents an omentoplasty technique designed to prevent colorectal postoperative anastomotic leakage. The technique focusing on the impalement of omentum into stapled anatomosis is discussed. Also noted is the observation that the technique is easier and faster when compared to suture fixation and omental wrapping.

Aims/hypothesis: The prevalence of births worldwide complicated by diabetes mellitus is increasing. In the UK, for example, <25% of diabetic women have a non-instrumental vaginal delivery. Strikingly, more than half the Caesarean sections (CS) in these patients are non-elective, but the reasons for this are not understood. We have tested the hypothesis that poor myometrial contractility as a consequence of the disease contributes to this high CS rate. Methods: We compared spontaneous, high K depolarisation and oxytocin-induced contractions from diabetic and matched control patients having an elective CS. To investigate the mechanism of any differences we measured intracellular Ca, and performed western blotting and compared the tissues histologically. Results: There was significantly decreased contraction amplitude and duration in uteri from diabetic compared with control patients, even when possible confounders such as BMI were analysed. Reduced intracellular calcium signals and expression of calcium entry channels were found in uteruses from diabetic patients, which, along with a reduction in muscle content found on histological examination, could explain the reduced force. Myometrium from diabetic patients was responsive to oxytocin, but still did not reach the levels found in non-diabetic patients. Conclusions/interpretations: These are the first data investigating myometrium in diabetic patients and they support the hypothesis that there is poorer contractility even in the presence of oxytocin. The underlying mechanism is related to reduced Ca channel expression and intracellular calcium signals and a decrease in muscle mass. We conclude that these factors significantly contribute to the increased emergency CS rate in diabetic patients. [ABSTRACT FROM AUTHOR]