1. Association between prehypertension, metabolic and inflammatory markers, decreased adiponectin and enhanced insulinemia in obese subjects
- Author
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Amanda Roberta de Almeida, Maurício Etchebehere, Sarah Monte-Alegre, Aglecio Luiz Souza, Michele Bianca Zanini, and José Antonio Rocha Gontijo
- Subjects
Inflammation ,medicine.medical_specialty ,Nutrition and Dietetics ,Adiponectin ,business.industry ,Research ,Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,medicine.disease ,Metabolic syndrome ,Prehypertension ,Endocrinology ,Blood pressure ,Insulin resistance ,Diabetes mellitus ,Internal medicine ,medicine ,Hyperinsulinemia ,Obesity ,business ,Dyslipidemia ,Renal function - Abstract
Background Obesity is associated with development of the cardiorenal metabolic syndrome, which is a constellation of risk factors, such as insulin resistance, inflammatory response, dyslipidemia, and high blood pressure that predispose affected individuals to well-characterized medical conditions such as diabetes, cardiovascular and kidney chronic disease. The study was designed to establish relationship between metabolic and inflammatory disorder, renal sodium retention and enhanced blood pressure in a group of obese subjects compared with age-matched, lean volunteers. Methods The study was performed after 14 h overnight fast after and before OGTT in 13 lean (BMI 22.92 ± 2.03 kg/m2) and, 27 obese (BMI 36.15 ± 3.84 kg/m2) volunteers. Assessment of HOMA-IR and QUICKI index were calculated and circulating concentrations of TNF-α, IL-6 and C-reactive protein, measured by immunoassay. Results The study shows that a hyperinsulinemic (HI: 10.85 ± 4.09 μg/ml) subgroup of well-characterized metabolic syndrome bearers-obese subjects show higher glycemic and elevated blood pressure levels when compared to lean and normoinsulinemic (NI: 5.51 ± 1.18 μg/ml, P
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