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This study analyzes associated factors to self-perceived oral health and use of oral health services in native and immigrant adults from the PELFI cohort in Spain. A cross-sectional analysis was conducted (401 adults ≥ 18 years, from Spain, Ecuador, Colombia and Morocco). Frequencies for sociodemographic, self-perceived general and oral health variables were calculated. The association between oral health/oral health services use and origin country was estimated by logistic regression (adjusted odds ratio-aOR-; 95% confidence intervals -95%CI-). Ecuadorian men were more likely to report dental caries (aPR 2.75; 95%CI 1.30–5.80) and Moroccan women were more likely to report gingival bleeding (aPR 3.61; 95%CI 1.83–7.15) and the use of oral health services ≥ 1 year/never (aPR 1.69; 95%CI 1.06–2.69). Colombian women were less likely to report missing teeth (aPR 0.73; 95%CI 0.56–0.95). Poor self-perceived oral health indicators were observed in immigrants and were modified for sociodemographic and general health variables. [ABSTRACT FROM AUTHOR]