9 results on '"Silva, Ricardo"'
Search Results
2. Altitude conditions seem to determine the evolution of COVID-19 in Brazil.
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Fernandes, José Sebastião Cunha, da Silva, Ricardo Siqueira, Silva, Alexandre Christófaro, Villela, Daniel Campos, Mendonça, Vanessa Amaral, and Lacerda, Ana Cristina Rodrigues
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COVID-19 pandemic , *DEATH rate , *HUMIDITY , *ANALYSIS of variance - Abstract
COVID-19 is spreading rapidly in Brazil, a country of continental dimensions, but the incidence of the disease is showing to be very heterogeneous, affecting cities and regions differently. Thus, there is a gap regarding what factors would contribute to accentuate the differences in the incidence of COVID-19 among Brazilian cities. This work aimed to evaluate the effect of altitude on the incidence of COVID-19 in Brazilian cities. We analyzed the relative incidence (RI), the relative death rate (RDR) of COVID-19, and air relative humidity (RH) in all 154 cities in Brazil with a population above 200 thousand inhabitants, located between 5 and 1135 m in altitude. Pearson's correlation analysis was performed to compare a relationship between altitude with RI and RDR, and between RH with RI and RDR. Altitudes were classified into three classes [low (altitude ≤ 97 m a. s. l), middle (97 < altitude ≤ 795 m a. s. l), high (795 < altitude ≤ 1135 m a. s. l)] for the RI, RDR, and RH variables. To compare the three classes of altitude, analysis of variance (ANOVA) and Tukey test were used to compare averages (p < 0.05). Our epidemiological analysis found that the RI, RDR, and RH were lower in cities located in high altitudes (795 < altitude ≤ 1135 m a. s. l) when compared to the middle (97 < altitude ≤ 795 m a. s. l) and low (altitude ≤ 97 m a. s. l) cities altitudes. Furthermore, our study shows that there is a negative correlation between the incidence of COVID-19 with altitude and a positive correlation with RH in the cities analyzed. Brazilian cities with high altitude and low RH have lower RI and RDR from COVID-19. Thus, high altitude cities may be favorable to shelter people at risk. This study may be useful for understanding the behavior of SARS-CoV2, and start point for future studies to establish causality of environmental conditions with SARS-CoV2 contributing to the implementation of measures to prevent and control the spread of COVID-19. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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3. The patient’s safety and access to experimental drugs after the termination of clinical trials: regulations and trends.
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da Silva, Ricardo Eccard, Amato, Angélica Amorim, Sousa, Thiago do Rego, de Carvalho, Marta Rodrigues, and Novaes, Maria Rita Carvalho Garbi
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INVESTIGATIONAL drugs , *CLINICAL trials , *REPORTING of diseases , *HEALTH services accessibility , *PATIENT safety , *DRUG approval , *RETROSPECTIVE studies , *MIDDLE-income countries , *LOW-income countries , *DRUG laws - Abstract
Purpose: Participants’ rights and safety must be guaranteed not only while a clinical trial is being conducted but also when a clinical trial finishes. The criteria for post-trial access to experimental drugs, however, are unclear in various countries. The objectives of this study were (i) to ascertain if there were regulations or guidelines related to patients’ access to drugs after the end of clinical trials in the countries selected in the study and (ii) to analyze trends in post-trial access in countries classified by their level of economic development.Methods: This study is a retrospective review. The data are from the records of clinical trials from 2014 registered in the World Health Organization’s International Clinical Trials Registry Platform (ICTRP) database.Results: Among the countries selected, provision of drugs post-trial is mandatory only in Argentina, Brazil, Chile, Finland, and Peru. The plans for post-trial access tend to be more present in low- and middle-income and upper middle-income countries, in comparison with high-income countries. Studies involving vulnerable populations are 2.53 times more likely to have plans for post-trial access than studies which do not.Conclusions: The guaranteeing of post-trial access remains mandatory in few countries. Considering that individuals seen as vulnerable have been included in clinical trials without plans for post-trial access, stakeholders must discuss the need to develop regulations mandating the guaranteeing of post-trial access in specified situations. [ABSTRACT FROM AUTHOR]
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- 2018
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4. Suicidality and Associated Factors in Pregnant Women in Brazil.
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Silva, Ricardo, Costa Ores, Liliane, Jansen, Karen, Silva Moraes, Inácia, Mattos Souza, Luciano, Magalhães, Pedro, and Pinheiro, Ricardo
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ANXIETY , *CONFIDENCE intervals , *MENTAL depression , *EPIDEMIOLOGY , *HAMILTON Depression Inventory , *MATERNAL age , *PROBABILITY theory , *PSYCHOLOGICAL tests , *RISK assessment , *SCALES (Weighing instruments) , *DATA analysis , *SOCIOECONOMIC factors , *SUICIDAL ideation , *CROSS-sectional method , *DESCRIPTIVE statistics , *PREGNANCY - Abstract
Is important to evaluate suicidal potential and related factors during pregnancy among women who have attended public health services. To determine the suicidal potential, question 10 from Edinburgh Postnatal Depression Scale (EPDS) was used. In this sample (N = 1,334), 8.1% of pregnant women demonstrated suicidal potential. The potential risk factors for suicide in depressed pregnant women were being single, divorced or widowed, thinking about having an abortion, and having anxiety symptoms; in nondepressed pregnant women were lower age, low education level, low socioeconomic class, thoughts about having an abortion and anxiety symptoms. [ABSTRACT FROM AUTHOR]
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- 2012
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5. Intraguild interaction between the predator Podisus nigrispinus (Hemiptera: Pentatomidae) and the parasitoid Palmistichus elaeisis (Hymenoptera: Eulophidae).
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Soares, Marcus Alvarenga, dos Santos, Marinalva Martins, de Castro e Castro, Barbara Monteiro, da Silva, Ricardo Siqueira, Leite, Germano Leão Demolin, Pires, Evaldo Martins, Lima, Eraldo, and Zanuncio, José Cola
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HYMENOPTERA , *EULOPHIDAE , *STINKBUGS , *TENEBRIO molitor , *INTEGRATED pest control , *BRACONIDAE , *HEMIPTERA - Abstract
Podisus nigrispinus (Dallas) (Hemiptera: Pentatomidae) and Palmistichus elaeisis (Delvare & LaSalle) (Hymenoptera: Eulophidae) are commercially used in the biological control of defoliating lepidopterans in Brazil. The combination of these natural enemies in integrated pest management systems and the risks of intraguild interactions in simultaneous releases were evaluated in the laboratory. The objective was to verify the possible biological effects of intraguild interaction between P. nigrispinus and P. elaeisis. Pupae of natural host Thyrinteina arnobia (Stoll) (Lepidoptera: Geometridae) and of the alternative host Tenebrio molitor L. (Coleoptera: Tenebrionidae), aged 24 hours, were individualized and exposed to parasitism by females of P. elaeisis for 24 hours. The selectivity of P. nigrispinus to parasitized prey was tested with T. arnobia, T. molitor and with volatile compounds extracted from pupae parasitized or healthy. The biomass of T. molitor pupae, healthy or parasitized by P. elaeisis (at one, nine or 18 days), consumed by P. nigrispinus was calculated. The selectivity of each P. nigrispinus female for healthy or parasitized pupae was observed and the effect on the biology of the predator was analysed. Podisus nigrispinus preferred healthy prey to those with more than one day of parasitism and was attracted to pupae washed with hexane extract from healthy hosts. The body mass of this predator was higher when feeding on healthy pupae. The intraguild interaction between P. nigrispinus and P. elaeisis is symmetrical, indicating that these natural enemies can be used, simultaneously, in the integrated management of defoliating caterpillars without reducing their efficiency. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Multilayer Networks Assisting to Untangle Direct and Indirect Pathogen Transmission in Bats.
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Alcantara, Daniel Maximo Correa, Ikeda, Priscila, Souza, Camila Silveira, de Mello, Victória Valente Califre, Torres, Jaire Marinho, Lourenço, Elizabete Captivo, Bassini-Silva, Ricardo, Herrera, Heitor Miraglia, Machado, Rosangela Zacarias, Barros-Battesti, Darci Moraes, Graciolli, Gustavo, and André, Marcos Rogério
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ECTOPARASITES , *LIFE cycles (Biology) , *BATS , *LIGHT transmission , *PATHOGENIC microorganisms , *EHRLICHIA - Abstract
The importance of species that connect the different types of interactions is becoming increasingly recognized, and this role may be related to specific attributes of these species. Multilayer networks have two or more layers, which represent different types of interactions, for example, between different parasites and hosts that are nonetheless connected. The understanding of the ecological relationship between bats, ectoparasites, and vector-borne bacteria could shed some light on the complex transmission cycles of these pathogens. In this study, we investigated a multilayer network in Brazil formed by interactions between bat-bacteria, bat-ectoparasite, and ectoparasite-bacteria, and asked how these interactions overlap considering different groups and transmission modes. The multilayer network was composed of 31 nodes (12 bat species, 14 ectoparasite species, and five bacteria genera) and 334 links, distributed over three layers. The multilayer network has low modularity and shows a core-periphery organization, that is, composed of a few generalist species with many interactions and many specialist species participating in few interactions in the multilayer network. The three layers were needed to accurately describe the multilayer structure, while aggregation leads to loss of information. Our findings also demonstrated that the multilayer network is influenced by a specific set of species that can easily be connected to the behavior, life cycle, and type of existing interactions of these species. Four bat species (Artibeus lituratus, A. planirostris, Phyllostomus discolor, and Platyrrhinus lineatus), one ectoparasite species (Steatonyssus) and three bacteria genera (Ehrlichia, hemotropic Mycoplasma and Neorickettsia) are the most important species for the multilayer network structure. Finally, our study brings an ecological perspective under a multilayer network approach on the interactions between bats, ectoparasites, and pathogens. By using a multilayer approach (different types of interactions), it was possible to better understand these different ecological interactions and how they affect each other, advancing our knowledge on the role of bats and ectoparasites as potential pathogen vectors and reservoirs, as well as the modes of transmission of these pathogens. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Temperament traits mediate the relationship between CACNA1C polymorphisms and bipolar disorder in cisgender women.
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Bastos, Clarissa Ribeiro, Bock, Bertha Bueno, Xavier, Janaina, Camerini, Laísa, Dewes, Samantha Seibt, Grellert, Mateus, de Carvalho, Hudson Wander, Jansen, Karen, da Silva, Ricardo Azevedo, Pinheiro, Ricardo Tavares, de Mattos Souza, Luciano, Oses, Jean Pierre, Portela, Luis Valmor, Lara, Diogo Rizzato, Tovo-Rodrigues, Luciana, and Ghisleni, Gabriele
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BIPOLAR disorder , *TEMPERAMENT , *SEX (Biology) , *HAPLOTYPES , *CISGENDER people - Abstract
The influence of temperament traits on bipolar disorder (BD) has been investigated. Both temperament traits and BD are partially genetically determined and seem to be influenced by variations in the CACNA1C gene. These variations presented a significant interactive effect with biological sex, although studies that evaluate this relationship are scarce. Here, we assessed the mediation effect of temperament traits on the relationship between two polymorphisms in the CACNA1C gene (rs1006737 and rs4765913) and BD according to sex. This is a cross-sectional study consisting of 878 Caucasian individuals (508 women and 370 men), aged 18–35, enrolled in a population-based study in the city of Pelotas, Southern Brazil. BD diagnosis was evaluated using the clinical interview MINI 5.0, and temperament traits were assessed via the application of the Affective and Emotional Composite Temperament Scale (AFECTS). Mediation models were tested using the modeling tool PROCESS (version 3.3) for SPSS. Bootstrapping-enhanced mediation analyses in women indicated that traits anger (39%) and caution (27%) mediated the association between the rs4765913 SNP and BD, while traits volition (29%), anger (35%), and caution (29%) mediated the association between the AA haplotype (rs1006737–rs4765913) and the BD. No effect was encountered for cisgender men. Our model revealed that paths from CACNA1C SNPs to BD are mediated by specific temperament traits in women, reinforcing the definition of temperament traits as endophenotypes. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Suicide Risk and Mood Disorders in Women in the Postpartum Period: a Longitudinal Study.
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de Avila Quevedo, Luciana, Scholl, Carolina Coelho, de Matos, Mariana Bonati, da Silva, Ricardo Azevedo, da Cunha Coelho, Fábio Monteiro, Pinheiro, Karen Amaral Tavares, and Pinheiro, Ricardo Tavares
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PUERPERIUM , *AFFECTIVE disorders , *SUICIDE , *WOMEN'S mental health , *POSTNATAL care - Abstract
Suicide associated with severe psychiatric illnesses is considered the leading cause of maternal deaths. We aimed to assess the suicide risk in women who experienced depressive or mixed episodes of mood change during the postpartum period and to determine which disorder is more related to suicide risk in the same period. We conducted a longitudinal study with 706 women whose children were born from April 2007 to May 2008 in a southern city in Brazil, and received prenatal care by the Brazilian National System of Public Health. The first assessment occurred during the prenatal period and the second within 30 to 60 days postpartum. The incidence of suicide risk was 10.9%. The odds of postpartum suicide risk were 6.50 (95% CI: 2.73; 15.48) higher in mothers with postpartum depression and 41.50 (95% CI: 12.11; 142.16) higher in those with mixed episodes than those who did not suffer from any mood disorder. Women with chronic episodes (who had depressive or mixed episodes during pregnancy and postpartum) were at increased odds of 4.94 (95% CI: 1.46; 16.69) of a postpartum suicide risk. The postpartum seems to be a critical period in the women's mental health. The impact of mental disorders in this period, especially mixed episodes, can increase the odds of a suicide risk onset. A good psychiatric evaluation and support during the prenatal and postpartum care may prevent the subsequent risk of suicide. [ABSTRACT FROM AUTHOR]
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- 2021
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9. Sustainable development opportunities within corporate social responsibility practices from LSM to ASM in the gold mining industry.
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Ribeiro-Duthie, A., Domingos, Líllian, Oliveira, Marina, Araujo, Patrícia, Alamino, Renata, Silva, Ricardo, Ribeiro-Duthie, James, and Castilhos, Zuleica
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GOLD mining , *MINERAL industries , *SUSTAINABLE development , *SOCIAL responsibility of business , *INDUSTRIAL safety - Abstract
Mining is an important part of the economy of several countries including Brazil. Despite the major role played by large-scale mining (LSM) in the mineral sector, artisanal and small-scale mining (ASM) also participates in the mining market and plays a crucial social role mainly in developing countries through assuring livelihoods for a great number of people. Both LSM and ASM can cause negative environmental and health impacts. Certification has been in focus for the LSM, following good practices and standards especially to improve health and safety performance. For ASM these issues still constitute a challenge. In some successful cases as corporate social responsibility (CSR) reports demonstrate, health, safety, and environment (HSE) impacts have been addressed through cooperation between LSM and ASM, which can benefit communities as a whole. A question guiding our research was whether there is potential for ASM gold mining certification to be a tool for achieving a win-win outcome within the gold mining sector, and for mercury emission reduction as proposed by the Minamata Convention. Brazilian ASM certification could become a market trend that would receive support from LSM towards the use of cleaner technologies and mining industry better practices? To answer that overarching question, our methodology included a review of CSR reports produced by LSM operating in Brazil and a comparison to their CSR initiatives worldwide. Field interviews with ASM miners were also undertaken. The results from LSM and ASM cooperation are classified with regard to types of initiatives to improve good practices guidance and promotion of sustainable development partnerships. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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