Search

Your search keyword '"Dubey, Sheri A."' showing total 1 results
Start Over Author "Dubey, Sheri A." Topic t cells Publisher springer nature
1 results on '"Dubey, Sheri A."'

1. Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells.

Author

Hutnick, Natalie A., Carnathan, Diane G., Dubey, Sheri A., Cox, Kara S., Kierstead, Lisa, Ratcliffe, Sarah J., Robertson, Michael N., Casimiro, Danilo R., Ertl, Hildegund C. J., and Betts, Michael R.

Subjects
AIDS vaccines, T cells, ADENOVIRUS diseases, VACCINATION
Abstract

The mechanisms underlying possible increased HIV-1 acquisition in adenovirus 5 (Ad5)-seropositive subjects vaccinated with Ad5–HIV-1 vectors in the Merck STEP trial remain unclear. We find that Ad5 serostatus does not predict Ad5-specific CD4+ T cell frequency, and we did not observe durable significant differences in Ad5-specific CD4+ T cells between Ad5-seropositive and Ad5-seronegative subjects after vaccination. These findings indicate no causative role for Ad5-specific CD4+ T cells in increasing HIV-1 susceptibility in the STEP trial. [ABSTRACT FROM AUTHOR]

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results