1. Ranibizumab for retinal angiomatous proliferation in age-related macular degeneration.
- Author
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Atmani, K., Voigt, M., Le Tien, V., Querques, G., Coscas, G., Soubrane, G., and Souied, E. H.
- Subjects
RETINAL degeneration treatment ,VISUAL acuity ,SURGICAL anastomosis ,NEOVASCULARIZATION ,AGE factors in disease ,OPTICAL coherence tomography ,FLUORESCENCE angiography - Abstract
PurposeTo assess the 1-year functional outcome and to evaluate the morphological changes after intravitreal injections of ranibizumab in eyes affected with retinal angiomatous proliferation (RAP) due to age-related macular degeneration (AMD).MethodsA prospective, non-randomized, interventional study was conducted on 26 consecutive patients with newly diagnosed RAP. All eyes were treatment naive and were randomized to receive intravitreal injections of ranibizumab for a 12-month period. After the first three monthly injections, re-treatment was performed in case of best-corrected visual acuity (BCVA) loss of at least five letters associated with fluid within the macula, central macular thickness (CMT) increase of at least 100 μm, and/or persistence of fluid within the macula as evaluated by optical coherence tomography, new onset macular haemorrhages, persistence of leakage from the lesions on fluorescein angiography.ResultsAll patients completed the 12-month follow-up: 25 of the 29 treated eyes (86.2%) were stabilized, with a loss of less than 15 letters. Nineteen eyes (65.5%) maintained or improved their BCVA, and three eyes (10.3%) gained three lines or more. Overall, mean BCVA remained stable at the 12-month follow-up (−0.07 letters; P>0.05). Mean CMT significantly decreased from 386±147 to 216±74 μm at the 12-month follow-up. No significant adverse events were observed during the study. The mean number of injections was 5.8±1.7 during the follow-up period.ConclusionThe 1-year follow-up outcomes in our series suggest that ranibizumab is an effective treatment for RAP in AMD, allowing stabilization of BCVA and reduction of CMT. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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