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In this paper, we carry out statistical fluctuation analysis for the new proposed measurement-device-independent quantum key distribution with heralded single-photon sources and further compare its performance with the mostly often used light sources, i.e., the weak coherent source. Due to a significantly lower probability for events with two photons present on the same side of the beam splitter in former than in latter, it gives drastically reduced quantum bit error rate in the X basis and can thus show splendid behavior in real-life implementations even when taking statistical fluctuations into account. [ABSTRACT FROM AUTHOR]