1. HLA-G in organ transplantation: towards clinical applications.
- Author
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Deschaseaux, Frederic, Delgado, Diego, Pistoia, Vito, Giuliani, Massimo, Morandi, Fabio, and Durrbach, Antoine
- Subjects
HLA histocompatibility antigens ,IMMUNOLOGICAL aspects of pregnancy ,TRANSPLANTATION immunology ,IMMUNOREGULATION ,MESENCHYMAL stem cells ,KILLER cells ,T cells - Abstract
HLA-G plays a particular role during pregnancy in which its expression at the feto-maternal barrier participates into the tolerance of the allogenic foetus. HLA-G has also been demonstrated to be expressed in some transplanted patients, suggesting that it regulates the allogenic response. In vitro data indicate that HLA-G modulates NK cells, T cells, and DC maturation through its interactions with various inhibitory receptors. In this paper, we will review the data reporting the HLA-G involvement of HLA-G in human organ transplantation, then factors that can modulate HLA-G, and finally the use of HLA-G as a therapeutic tool in organ transplantation. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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