1. H2S Attenuates Sleep Deprivation-Induced Cognitive Impairment by Reducing Excessive Autophagy via Hippocampal Sirt-1 in WISTAR RATS.
- Author
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Gao, Shan, Tang, Yi-Yun, Jiang, Li, Lan, Fang, Li, Xiang, Zhang, Ping, Zou, Wei, Chen, Yong-Jun, and Tang, Xiao-Qing
- Subjects
LABORATORY rats ,AUTOPHAGY ,COGNITIVE ability ,COGNITION disorders ,HIPPOCAMPUS (Brain) ,RATS ,SLEEP deprivation - Abstract
Sleep deprivation (SD) is widespread in society causing serious damage to cognitive function. Hydrogen sulfide (H
2 S), the third gas signal molecule, plays important regulatory role in learning and memory functions. Inhibition of excessive autophagy and upregulation of silent information regulator 1 (Sirt-1) have been reported to prevent cognitive dysfunction. Therefore, this present work was to address whether H2 S attenuates the cognitive impairment induced by SD in Wistar rats and whether the underlying mechanisms involve in inhibition of excessive autophagy and upregulation of Sirt-1. After treatment with SD for 72 h, the cognitive function of Wistar rats was evaluated by Y-maze, new object recognition, object location, and Morris water maze tests. The results shown that SD-caused cognitive impairment was reversed by treatment with NaHS (a donor of H2 S). NaHS also prevented SD-induced hippocampal excessive autophagy, as evidenced by the decrease in autophagosomes, the down-regulation of Beclin1, and the up-regulation of p62 in the hippocampus of SD-exposed Wistar rats. Furthermore, Sirtinol, an inhibitor of Sirt-1, reversed the inhibitory roles of NaHS in SD-induced cognitive impairment and excessive hippocampal autophagy in Wistar rats. Taken together, our results suggested that H2 S improves the cognitive function of SD-exposed rats by inhibiting excessive hippocampal autophagy in a hippocampal Sirt-1-dependent way. [ABSTRACT FROM AUTHOR]- Published
- 2021
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