1. An ultra-small organic dye nanocluster for enhancing NIR-II imaging-guided surgery outcomes.
- Author
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Wang, Yajun, Zhou, Ding, Ma, Huilong, Liu, Dahai, Liang, Yongye, and Zhu, Shoujun
- Subjects
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SENTINEL lymph nodes , *ORGANIC dyes , *BIOFLUORESCENCE , *LYMPHADENECTOMY , *DYES & dyeing - Abstract
Purpose: The accuracy of surgery for patients with solid tumors can be greatly improved through fluorescence-guided surgery (FGS). However, existing FGS technologies have limitations due to their low penetration depth and sensitivity/selectivity, which are particularly prevalent in the relatively short imaging window (< 900 nm). A solution to these issues is near-infrared-II (NIR-II) FGS, which benefits from low autofluorescence and scattering under the long imaging window (> 900 nm). However, the inherent self-assembly of organic dyes has led to high accumulation in main organs, resulting in significant background signals and potential long-term toxicity. Methods: We rationalize the donor structure of donor–acceptor-donor-based dyes to control the self-assembly process to form an ultra-small dye nanocluster, thus facilitating renal excretion and minimizing background signals. Results: Our dye nanocluster can not only show clear vessel imaging, tumor and tumor sentinel lymph nodes definition, but also achieve high-performance NIR-II imaging-guided surgery of tumor-positive sentinel lymph nodes. Conclusion: In summary, our study demonstrates that the dye nanocluster-based NIR-II FGS has substantially improved outcomes for radical lymphadenectomy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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