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Your search keyword '"Su, Wenjing"' showing total 1 results
Start Over Author "Su, Wenjing" Topic cisplatin Publisher springer nature
1 results on '"Su, Wenjing"'

1. SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α.

Author

Ao, Qilin, Su, Wenjing, Guo, Shuang, Cai, Lei, and Huang, Lei

Subjects
*HYPOXIA-inducible factor 1, *OVARIAN cancer, *CANCER cells, *CISPLATIN, *CANCER chemotherapy
Abstract

Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still controversial. In this study, we identified that SENP1 positively regulated the expression of HIF-1α by deSUMOylation and weakened the sensitivity of hypoxic ovarian cancer cells to cisplatin. These results indicate that SENP1 is a positive regulator of HIF-1α and plays a negative role in ovarian cancer chemotherapy. [ABSTRACT FROM AUTHOR]

Published
2015
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