1. Mitochondrial recoupling: a novel therapeutic strategy for cancer?
- Author
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Baffy, G., Derdak, Z., and Robson, S. C.
- Subjects
ALTERNATIVE treatment for cancer ,MITOCHONDRIAL pathology ,GLYCOLYSIS ,SUPEROXIDES ,OXIDATIVE stress ,P53 antioncogene ,ADENOSINES - Abstract
Recent findings link metabolic transformation of cancer cells to aberrant functions of mitochondrial uncoupling proteins (UCPs). By inducing proton leak, UCPs interfere with mitochondrial synthesis of adenosine 5'-triphosphate, which is also a key determinant of glycolytic pathways. In addition, UCP suppress the generation of superoxide, a byproduct of mitochondrial electron transport and a major source of oxidative stress. The near ubiquitous UCP2 becomes highly abundant in some cancers and may advance metabolic reprogramming, further disrupt tumour suppression, and promote chemoresistance. Here we review current evidence to suggest that inhibition of mitochondrial uncoupling may eliminate these responses and reveal novel anti-cancer strategies. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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