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NNJ guest editors Giuseppe Fallacara and Maurizio Barberio introduce the papers in the special issue of the Nexus Network Journal dedicated to Stereotomy 2.0. [ABSTRACT FROM AUTHOR]

The aim of the article is to describe the historical background and the birth of a relatively new discipline consisting in the digital evolution of classical stereotomy. “Stereotomy 1.0” comprises the early development of the discipline primarily related to stonecutting. The new discipline, “Stereotomy 2.0” goes beyond this early concept to embrace contemporary design paradigms and materials. It is described in an “Unfinished Manifesto”, which describes its fundamental theoretical principles, understood as a new didactic comprehensive approach for the schools of architecture and a new design process useful for contemporary architectural design. Each point of the Manifesto is described in a short paragraph and shows the most important theoretical nodes of the renewed discipline. The various points are then exemplified by the experimental projects presented in the final part of the article. [ABSTRACT FROM AUTHOR]

Liver ischaemia reperfusion injury (IRI) is a dreaded pathophysiological complication which may lead to an impaired liver function. The level of oxygen hypoperfusion affects the level of cellular damage during the reperfusion phase. Consequently, intraoperative localisation and quantification of oxygen impairment would help in the early detection of liver ischaemia. To date, there is no real-time, non-invasive, and intraoperative tool which can compute an organ oxygenation map, quantify and discriminate different types of vascular occlusions intraoperatively. Hyperspectral imaging (HSI) is a non-invasive optical methodology which can quantify tissue oxygenation and which has recently been applied to the medical field. A hyperspectral camera detects the relative reflectance of a tissue in the range of 500 to 1000 nm, allowing the quantification of organic compounds such as oxygenated and deoxygenated haemoglobin at different depths. Here, we show the first comparative study of liver oxygenation by means of HSI quantification in a model of total vascular inflow occlusion (VIO) vs. hepatic artery occlusion (HAO), correlating optical properties with capillary lactate and histopathological evaluation. We found that liver HSI could discriminate between VIO and HAO. These results were confirmed via cross-validation of HSI which detected and quantified intestinal congestion in VIO. A significant correlation between the near-infrared spectra and capillary lactate was found (r = − 0.8645, p = 0.0003 VIO, r = − 0.7113, p = 0.0120 HAO). Finally, a statistically significant negative correlation was found between the histology score and the near-infrared parameter index (NIR) (r = − 0.88, p = 0.004). We infer that HSI, by predicting capillary lactates and the histopathological score, would be a suitable non-invasive tool for intraoperative liver perfusion assessment. [ABSTRACT FROM AUTHOR]