In recent years, the therapeutic application of botulinum neurotoxin (BoNT) has expanded to encompass a variety of issues beyond its well-known usage for hyperkinetic movement disorders, autonomic hyperactivity, and facial rejuvenation. Dentistry is one of the fields that has benefited greatly from botulinum toxin therapy, as evidenced by multiple clinical trials which provided evidence for usefulness of this mode of therapy in common issues encountered in the field of dentistry (described in Chap. 16). In this chapter, the future potentials for BoNT therapy in the field of dentistry and its use in oral and maxillofacial region with its rich network of nerves and muscles are described. In addition, this chapter focuses on preclinical and preliminary studies on the effect of intramuscular injections of BoNT on craniofacial growth and proposes the possibility of using this toxin to influence the dentofacial complex during growth. Existing data or suggestions on the use of BoNT in implant dentistry, tongue thrust, temporomandibular joint dislocation, bone/plate fractures, herpes simplex virus, angular cheilitis, and burning mouth syndrome are also presented.