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Patients often present for lip augmentation to correct the loss of volume and signs of aging commonly perceived with perioral aging, including but not limited to decreased vermillion showing, blunting of the Cupid’s bow, less visible white roll, vertical rhytids, marionette lines, formation of a mentalis crease, and deep nasolabial folds. Hyaluronic acid (HA) is popular filler for temporary lip augmentation (effects last 3–6 months) due to its hygroscopic properties and resulting natural appearance. Additionally, they have desirable safety profiles due to the reversibility by enzymatic degradation using hyalurodinase. Keeping in mind the important anatomy of the perioral region and its vascular supply and nerve innervation is essential to a successful procedure with good cosmetic results. This chapter includes detailed guidelines and a technique for injecting. Physicians should consult with patients as to their preferences for a desired look, but carefully manage expectations to avoid disappointments. HA fillers are well tolerated and rarely result in adverse reactions for patients. Commonly experienced reactions can include local inflammation, tenderness, and bruising. HA fillers are an effective first-line treatment option for patients who want to augment and revitalize their lips.

First approved in 1989 for the treatment of various neuromuscular disorders, it was not until 2002 that the US Food and Drug Administration (FDA) approved botulinum toxin for its first dermatologic application: enhanced cosmesis of glabellar lines. By 2004, the FDA extended its approval of onabotulinumtoxin A, or Botox®, to the treatment of primary axillary hyperhidrosis refractory to treatment with topical agents [1].