Search

Introduction: Transarterial radioembolization (TARE) is a form of brachytherapy in which microspheres loaded with the radioactive isotope yttrium-90 (90Y) are injected selectively to the tumor-feeding arteries through a catheter using fluoroscopic guidance. The use of 90Y microspheres leads to tumor necrosis by delivering a high radiation dose (>70 Gy, tumoricidal threshold) directly to HCC nodules, sparing the non-tumoral liver, and with little or no embolic effect on the vessels. Resin 90Y microspheres are 20–60 μm in size, carry approximately 50 Bq/sphere, and contain 40–80 million microspheres per 3 GBq (1 vial).

Background We evaluated the feasibility and accuracy of 11C–choline PET-CT/TRUS fusion-guided prostate biopsy in men with persistently elevated PSA and negative mpMRI or contraindication to MRI, after previous negative biopsy. Clinical data were part of a prospective on-going observational clinical study: “Diagnostic accuracy of target mpMRI/US fusion biopsy in patients with suspected prostate cancer after initial negative biopsy”. Patients with a negative biopsy and negative mpMRI (PI-RADS v.2 6. Over 58 cores, 25 (43.1%) were positive. No statistically significant difference in terms of mean and median values for SUVmax and SUVratio between benign and malignant lesions was found. PCa lesions with GS 3 + 3 (n = 3) showed a median SUVmax and SUVratio of 4.01 and 1.46, compared to 5.45 and 1.57, respectively for lesions with GS >6 (n = 4). Conclusion Software PET-CT/TRUS fusion-guided target biopsy could be a diagnostic alternative in patients with a suspected primary PCa and negative mpMRI, but its specificity appeared low.