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Objectives: The COVID-19 pandemic and the consequent lockdown came as a storm disrupting people’s everyday life. This study aimed at observing whether the COVID-19 related lockdown influenced migraine frequency and disability in migraine patients on therapy with monoclonal antibodies inhibiting the CGRP pathway. Methods: In this longitudinal observational cohort study, 147 consecutive patients receiving monthly administration of erenumab or galcanezumab were enrolled in four Italian headache centers. All patients filled a questionnaire concerning working and household settings, recent flu symptoms or COVID-19 diagnosis, and family loss due to COVID-19 infection. Monthly migraine days (MMDs), monthly painkiller intake (MPI), and HIT-6 disability relative to the first month of lockdown imposition (T-lock) and the month before (T-free) were also collected. Results: From T-free to T-lock, the cohort displayed a reduction in MMDs (from 10.5 ± 7.6 to 9.8 ± 7.6, p =.024) and HIT-6 scores (from 59.3 ± 8.3 men reduced MPI more frequently than women (p =.005). Conclusions: Our study observed that the lockdown impact to 57.8 ± 8.8, p=.009), while MPI resulted unchanged (from 11.6 ± 11.5 to 11.1 ± 11.7; p =.114). MMDs, MPI, and HIT-6 variations from T-free to T-lock did not differ according to work settings or household. Patients beyond the first 3 months of therapy presented less often a reduction in MMDs (p =.006) and on everyday life did not affect the migraine load in patients receiving monoclonal antibodies inhibiting the CGRP pathway. Patients in the first months of therapy experienced a greater improvement according to drug pharmacokinetics, while women more frequently needed rescue medications, possibly indicating presenteeism or cephalalgophobia.

The present contribution proposes three projects and relative speculative reflections, elaborated by the writers, concerning the important theme of the wooden roof construction, showing the results of the three competitions organized by the Terres de Hetre® consortium, entitled: “L’architecture au service de construction en bois de hetre des vosges”. The three projects, object of the paper (awarded with the third placement during the first edition and with the second placement during the third edition), describe an effort to demonstrate new applications, characteristics, shapes and unexpected unexpressed potentials of this traditional material for a new contemporary design; they are architectures that have the common characteristic of being all a great challenge to the intrinsic limits of the wooden material: in all the outcomes results the research of geometric complexity and the limit of the static-mechanical resistance of the elements is evident. The architectural forms are developed starting from a series of geometric and topological variations on the theme of the wood-frame roof: the first with powerful overhangs on the model of the gull-wing structure, the second on the tree-shape model and the third on the shell-ruled–surface model.