1. Short-term time-restricted feeding is safe and feasible in non-obese healthy midlife and older adults
- Author
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Melissa R. Mazzo, Douglas R. Seals, Brian P. Ziemba, Sarah A. Johnson, Matthew J. Rossman, Michel Chonchol, Christopher R. Martens, Lindsey R Jankowski, Erzsebet E. Nagy, Yang Wang, Blair A Denman, James J Richey, and Courtney M. Peterson
- Subjects
Male ,Aging ,Pediatrics ,medicine.medical_specialty ,Bone density ,Calorie restriction ,Pilot Projects ,Cardiovascular System ,Weight loss ,Intermittent fasting ,medicine ,Humans ,Aged ,Caloric Restriction ,business.industry ,Fasting ,Middle Aged ,medicine.disease ,Malnutrition ,Tolerability ,Cohort ,Lean body mass ,Original Article ,Female ,Geriatrics and Gerontology ,medicine.symptom ,business ,Energy Intake - Abstract
Chronic calorie restriction (CR) improves cardiovascular function and several other physiological markers of healthspan. However, CR is impractical in non-obese older humans due to potential loss of lean mass and bone density, poor adherence, and risk of malnutrition. Time-restricted feeding (TRF), which limits the daily feeding period without requiring a reduction in calorie intake, may be a promising alternative healthspan—extending strategy for midlife and older adults; however, there is limited evidence for its feasibility and efficacy in humans. We conducted a randomized, controlled pilot study to assess the safety, tolerability, and overall feasibility of short-term TRF (eating
- Published
- 2020