1. Computed tomography features and predictive findings of ruptured gastrointestinal stromal tumours.
- Author
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Kim JS, Kim HJ, Park SH, Lee JS, Kim AY, and Ha HK
- Subjects
- Adult, Aged, Aged, 80 and over, Antineoplastic Agents therapeutic use, Ascites diagnostic imaging, Ascites etiology, Disease Progression, Female, Gastrointestinal Neoplasms drug therapy, Gastrointestinal Stromal Tumors drug therapy, Hematoma diagnostic imaging, Hematoma etiology, Hemoperitoneum diagnostic imaging, Hemoperitoneum etiology, Humans, Imatinib Mesylate therapeutic use, Indoles therapeutic use, Intestine, Small pathology, Male, Middle Aged, Necrosis etiology, Peritonitis diagnostic imaging, Peritonitis drug therapy, Pyrroles therapeutic use, Rupture, Spontaneous, Sensitivity and Specificity, Sunitinib, Tomography, X-Ray Computed methods, Young Adult, Gastrointestinal Neoplasms diagnostic imaging, Gastrointestinal Stromal Tumors diagnostic imaging, Tomography, X-Ray Computed standards
- Abstract
Objectives: To evaluate the CT features of ruptured GISTs and factors that might be predictive of rupture through comparison with CTs taken prior to rupture and CTs of non-ruptured GIST., Methods: Forty-nine patients with ruptured GIST and forty-nine patients with non-ruptured GIST matched by age, gender and location were included. Clinical data including pharmacotherapy were reviewed. The imaging features were analyzed. Prior CT obtained before rupture were evaluated., Results: The most common location of ruptured GIST was small bowel with mean size of 12.1 cm. Ruptured GIST commonly showed wall defects, >40 % eccentric necrosis, lobulated shaped, air density in mass, pneumoperitoneum, peritonitis, hemoperitoneum and ascites (p < 0.001-0.030). Twenty-seven of 30 patients with follow up imaging received targeted therapy. During follow-up, thickness of the tumour wall decreased. Increase in size and progression of necrosis were common during targeted therapy (p = 0.017). Newly developed ascites, peritonitis and hemoperitoneum was more common (p < 0.001-0.036)., Conclusion: Ruptured GISTs commonly demonstrate large size, >40 % eccentric necrosis, wall defects and lobulated shape. The progression of necrosis with increase in size and decreased wall thickness during targeted therapy may increase the risk of rupture. Rupture should be considered when newly developed peritonitis, hemoperitoneum, or ascites are noted during the follow-up., Key Points: • Ruptured GISTs demonstrate large size, eccentric necrosis, wall defects, and lobulated shape. • Rupture should be considered when peritonitis or hemoperitoneum/adjacent hematoma newly appears. • Progression of necrosis with increase in size increases the risk of rupture.
- Published
- 2017
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