1. Total mesorectal excision for rectal cancer in an unselected population: quality assessment in a low volume center.
- Author
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Ferenschild FT, Dawson I, de Wilt JH, de Graaf EJ, Groenendijk RP, and Tetteroo GW
- Subjects
- Adenocarcinoma mortality, Adenocarcinoma secondary, Adult, Age Factors, Aged, Aged, 80 and over, Databases as Topic, Disease-Free Survival, Feasibility Studies, Hospitals, Community statistics & numerical data, Hospitals, Teaching statistics & numerical data, Humans, Kaplan-Meier Estimate, Middle Aged, Neoplasm Recurrence, Local, Proportional Hazards Models, Rectal Neoplasms mortality, Rectal Neoplasms pathology, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Adenocarcinoma surgery, Digestive System Surgical Procedures adverse effects, Digestive System Surgical Procedures mortality, Digestive System Surgical Procedures statistics & numerical data, Outcome and Process Assessment, Health Care statistics & numerical data, Quality of Health Care statistics & numerical data, Rectal Neoplasms surgery, Workload statistics & numerical data
- Abstract
Objective: The aim of this study was to review the results and long-term outcome after total mesorectal excision (TME) for adenocarcinoma of the rectum in an unselected population in a community teaching hospital., Materials and Methods: Between 1996 and 2003, 210 patients with rectal cancer were identified in our prospective database, containing patient characteristics, radiotherapy plans, operation notes, histopathological reports, and follow-up details. An evaluation of prognostic factors for local recurrence, distant metastases, and overall survival was performed., Results: The mean age at diagnosis was 69 years (range 40-91 years). A total of 145 patients were treated by anterior rectal resection; 65 patients had to undergo an abdominoperineal resection (APR). Anastomotic leakage rate was 5%. Postoperative mortality was 3%. After a median follow-up of 3.6 years, the local recurrence-free rate in patients with microscopically complete resections was 91%. The 5-year overall survival rate was 58%. An increased serum carcinoembryonic antigen, an APR, positive lymph nodes, and an incomplete resection all significantly influenced the 5-year overall survival and local recurrence rate. In a multivariate analysis, age was the most important prognostic factor for overall survival., Conclusions: Patients with rectal cancer can safely be treated with TME in a community teaching hospital and leads to a good overall survival and an excellent local control. In patients aged above 80, treatment-related mortality is an important competitive risk factor, which obscures the positive effect of modern rectal cancer treatment.
- Published
- 2009
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