1. Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain.
- Author
-
Billon-Denis E, Ferrier-Rembert A, Garnier A, Cheutin L, Vigne C, Tessier E, Denis J, Badaut C, Rougeaux C, Depeille Wuille A, Timera H, Boutin LI, Drouet I, Verguet N, Nolent F, Gorgé O, Ferraris O, and Tournier JN
- Subjects
- Adult, Antibodies, Neutralizing biosynthesis, COVID-19 transmission, Cross Infection immunology, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin G biosynthesis, Male, Middle Aged, Nasopharynx virology, SARS-CoV-2 classification, SARS-CoV-2 genetics, Antibodies, Neutralizing blood, Antibodies, Viral blood, COVID-19 immunology, Immunoglobulin G blood, Infectious Disease Transmission, Patient-to-Professional, SARS-CoV-2 immunology
- Abstract
Background: We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes., Case: One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers., Discussion and Conclusion: Thus, host individual factors may be the main drivers of the immune response varying with age and clinical severity., (© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2021
- Full Text
- View/download PDF