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WOS: 000474396700008, PubMed: 30415440, ObjectiveThe aim of this in vitro study is to evaluate the effects of resveratrol (RES) addition on the cytotoxicity and microtensile bond strength (mu TBS) of different adhesives.Materials and methodsFive self-etching adhesives (G-aenial Bond-GC, Optibond All in One-Kerr, Gluma Self Etch-Kulzer, Clearfil S-3 Bond-Kuraray, and Nova Compo-B Plus-Imicryl) were tested. They were applied to L-929 cell culture by the extract method. In the test groups, 0.5 mu M RES (Sigma-Aldrich) was added into the medium. Cell viability was assessed by MTT assay after 24h. Human extracted third molars were used for mu TBS test (n=7). The adhesives with or without 0.5 mu M RES addition were applied on dentin surfaces. A composite build-up was constructed. Then, the specimens were sectioned into multiple beams with the non-trimming version of the microtensile test and subjected to microtensile forces. Statistical analysis was performed using ANOVA and post hoc Tukey test (p?0.05).ResultsThe extracts of all adhesives decreased the cell viability. However, RES addition increased the cell viability in all groups (p?0.05). RES addition did not cause any decrease in mu TBS values of the adhesives compared to baseline. Optibond All in One showed the highest mu TBS after RES addition. It was followed by Clerafil S-3 Bond and Nova Compo-B Plus. No difference was determined between the Optibond All in One and Clearfil S-3 Bond. There was difference between Optibond All in One and Nova Compo-B Plus (p?0.05).ConclusionRES addition may improve the biocompatibility without causing negative influence on mu TBS of the adhesives.Clinical relevanceRES addition has clinical applicable potential to overcome the adverse biocompatibility of adhesives.