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Your search keyword '"cytogenetic abnormality"' showing total 16 results
Start Over Descriptor "cytogenetic abnormality" Publisher springer berlin heidelberg
16 results on '"cytogenetic abnormality"'

13. Chromosomal Abnormalities in Myeloid Hematologic Malignancies

Author

Rubin, C. M., Le Beau, M. M., Compans, R. W., editor, Cooper, M., editor, Koprowski, H., editor, McConell, I., editor, Melchers, F., editor, Nussenzweig, V., editor, Oldstone, M., editor, Olsnes, S., editor, Saedler, H., editor, Vogt, P. K., editor, Wagner, H., editor, Wilson, I., editor, Shen-Ong, Grace L. C., editor, Potter, Michael, editor, and Copeland, Neal G., editor

Published
1989
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14. Acute Lymphoblastic Leukemia Identification Using Blood Smear Images and a Neural Classifier

Author

Adnan Khashman and Hayder H. Abbas

Subjects
Diagnostic methods, Artificial neural network, Computer science, business.industry, Lymphoblastic Leukemia, Pattern recognition, medicine.disease, Leukemia, Blood smear, Cytogenetic Abnormality, medicine, Artificial intelligence, business, Classifier (UML)
Abstract

There is a need for fast and cost-effective leukemia identification methods, because early identification could increase the likelihood of recovery. Currently, diagnostic methods require sophisticated expensive laboratories such as immune-phenotype and cytogenetic abnormality. Therefore, we propose an identification method based on using blood smear images of normal and cancerous cells, in addition to a neural network classifier. We focus in this paper on identifying Acute Lumphoblastic Leukemia (ALL) cases, and implement our experiments following three learning schemes for a neural model. The neural classifiers distinguish between normal blood cells and ALL-infected cells. The experimental results show that the proposed novel leukemia identification system can be effectively used for such a task, and thus could be implemented for identifying other leukemia types in real life applications.

Published
2013
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15. Cytogenetic Diagnosis of Myelodysplastic Syndromes

Author

Michelle M. Le Beau and Harold J. Olney

Subjects
Oncology, medicine.medical_specialty, Acute leukemia, Bone marrow sample, business.industry, Myelodysplastic syndromes, Refractory anemia, Myeloid leukemia, medicine.disease, hemic and lymphatic diseases, Cytogenetic Abnormality, Internal medicine, medicine, Clinical care, business, Median survival
Abstract

The cytogenetic evaluation of a bone marrow sample from patients with a myelodysplastic syndrome (MDS) is an integral part of clinical care. This analysis not only confirms the diagnosis, but it is invaluable in defining the prognosis and median survival, as well as establishing the risk for progression to an acute myeloid leukemia (AML). On a more fundamental level, cytogenetic analysis has been instrumental in confirming the clonality of these syndromes as well as providing hints into the pathobiology of these entities. This chapter will review the most frequently encountered abnormalities exploring their clinical and genetic features, as well as the techniques of cytogenetic analysis and their applications in MDS.

Published
2006
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16. Discussion

Author

Bessis, Marcel, Brecher, George, Bessis, Marcel, editor, and Brecher, George, editor

Published
1975
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