1. Cognitive Function in Adults Aging with Fabry Disease: A Case–Control Feasibility Study Using Telephone-Based Assessments
- Author
-
Virginia Clarke, Robert J. Hopkin, Manjula Kurella Tamura, Caroline L. Lassen-Greene, Dawn Laney, Katherine B. Sims, David G. Warnock, George Howard, Virginia G. Wadley, and Leslie A. McClure
- Subjects
Gerontology ,Elementary cognitive task ,education.field_of_study ,medicine.medical_specialty ,Recall ,Population ,Confounding ,Cognition ,Audiology ,Article ,Quality of life ,medicine ,Cognitive skill ,education ,Psychology ,Generalized estimating equation - Abstract
We examined the feasibility of recruiting US adults ≥45 years old with Fabry disease (FD) for telephone assessments of cognitive functioning. A case–control design matched each FD participant on age, sex, race, and education to four participants from a population-based study. Fifty-four participants with FD age 46–72 years were matched to 216 controls. Standardized cognitive assessments, quality of life (QOL), and medical histories were obtained by phone, supplemented by objective indices of comorbidities. Normalized scores on six cognitive tasks were calculated. On the individual tasks, scores on list recall and semantic fluency were significantly lower among FD participants (p-values
- Published
- 2014
- Full Text
- View/download PDF