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Your search keyword '"Oxygen transfer rate"' showing total 26 results
Start Over Descriptor "Oxygen transfer rate" Publisher springer berlin heidelberg
26 results on '"Oxygen transfer rate"'

11. Bioreactor Models

Author

Schügerl, Karl, Bellgardt, Karl-Heinz, Schügerl, Karl, editor, and Bellgardt, Karl-Heinz, editor

Published
2000
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12. Reaction engineering methods to study intracellular metabolite concentrations

Author

Weuster-Botz, D., de Graaf, A. A., Scheper, T., editor, Fiechter, A., editor, Blanch, H. W., editor, Cooney, Ch. L., editor, Demain, A. L., editor, Enfors, S. -O., editor, Eriksson, K. -E. L., editor, Klibanov, A. M., editor, Lafferty, R. M., editor, Mattiasson, B., editor, Primrose, S. B., editor, Rehm, H. J., editor, Rogers, P. L., editor, Sahm, H., editor, Schügerl, K., editor, von Stockar, U., editor, Tsao, G. T., editor, Venkat, K., editor, Villadsen, John, editor, and Wandrey, C., editor

Published
1996
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13. New concepts for quantitative bioprocess research and development

Author

Sonnleitner, Bernhard, Scheper, T., editor, Fiechter, A., editor, Blanch, H. W., editor, Cooney, Ch. L., editor, Demain, A. L., editor, Enfors, S. -O., editor, Eriksson, K. -E. L., editor, Klibanov, A. M., editor, Lafferty, R. M., editor, Mattiasson, B., editor, Primrose, S. B., editor, Rehm, H. J., editor, Rogers, P. L., editor, Sahm, H., editor, Schügerl, K., editor, von Stockar, U., editor, Tsao, G. T., editor, Venkat, K., editor, Villadsen, John, editor, and Wandrey, C., editor

Published
1996
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16. Industrial animal cell reactor systems: Aspects of selection and evaluation

Author

Bliem, R., Konopitzky, K., Katinger, H., Fiechter, A., editor, Aiba, S., editor, Bungay, H. R., editor, Cooney, Ch. L., editor, Demain, A. L., editor, Fukui, S., editor, Kieslich, K., editor, Klibanov, A. M., editor, Lafferty, R. M., editor, Primrose, S. B., editor, Rehm, H. J., editor, Rogers, P. L., editor, Sahm, H., editor, Schügerl, K., editor, Suzuki, S., editor, Tsao, G. T., editor, Venkat, K., editor, and Winnacker, E. -L., editor

Published
1991
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19. Oxygen transfer into highly viscous media

Author

Schügerl, K., Fiechter, A., editor, Aiba, S., editor, Atkinson, B., editor, Böing, J., editor, Bylinkina, E., editor, Dellweg, H., editor, Demain, A. L., editor, Finn, R., editor, Fukui, S., editor, Kieslich, K., editor, Lafferty, R. M., editor, Mosbach, K., editor, Rehm, H. J., editor, Rogers, P. L., editor, Sahm, H., editor, Schügerl, K., editor, Suomalainen, H., editor, and Tsao, G. T., editor

Published
1981
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20. Mathematical modelling, parameter identification and adaptive control of single cell protein processes in tower loop bioreactors

Author

Luttmann, Reiner, Munack, Axel, Thoma, Manfred, Fiechter, A., editor, Aiba, S., editor, Bungoy, H. R., editor, Cooney, Ch. L., editor, Demain, A. L., editor, Fukui, S., editor, Kieslich, K., editor, Klibanov, A. M., editor, Lafferty, R. M., editor, Montenecourt, B. S., editor, Rehm, H. J., editor, Rogers, P. L., editor, Sahm, H., editor, Schügerl, K., editor, Suzuki, S., editor, Taguchi, H., editor, Tsao, G. T., editor, and Winnacker, E. -L., editor

Published
1985
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21. Characterization and performance of single- and multistage tower reactors with outer loop for cell mass production

Author

Schügerl, Karl, Fiechter, A., editor, Aiba, S., editor, Atkinson, B., editor, Böing, J., editor, Bylinkina, E., editor, Dellweg, H., editor, Demain, A. L., editor, Finn, R., editor, Fukui, S., editor, Kieslich, K., editor, Lafferty, R. M., editor, Mosbach, K., editor, Rehm, H. J., editor, Rogers, P. L., editor, Sahm, H., editor, Schügerl, K., editor, Suomalainen, H., editor, and Tsao, G. T., editor

Published
1982
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26. Use of Orbital Shaken Disposable Bioreactors for Mammalian Cell Cultures from the Milliliter-Scale to the 1,000-Liter Scale

Author

Florian M. Wurm, Marco Perrone, Nicola Parolini, Xiaowei Zhang, Alfio Quarteroni, Maria De Jesus, David L. Hacker, Matthieu Stettler, Marco Discacciati, and Dario De Sanctis

Subjects
Microtiter Plates, Oxygen transfer, Scale-up, Cultivation, Growth, Mammalian cell culture, Laboratory flask, Mammalian cell, Suspension, Bioreactor, Orbital shaking, Oxygen transfer rate, Integrated Oxygen Sensors, Chromatography, Flasks, Chemistry, Protein, Scale (chemistry), Shaken bioreactor, technology, industry, and agriculture, Liquid Mass-Transfer, Shaking Bioreactors, equipment and supplies, Transient Gene-Expression, Cell culture, Disposable bioreactor, SCALE-UP, Disposable bioreactors, Biochemical engineering
Abstract

Driven by the commercial success of recombinant biopharmaceuticals, there is an increasing demand for novel mammalian cell culture bioreactor systems for the rapid production of biologicals that require mammalian protein processing. Recently, orbitally shaken bioreactors at scales from 50 mL to 1,000 L have been explored for the cultivation of mammalian cells and are considered to be attractive alternatives to conventional stirred-tank bioreactors because of increased flexibility and reduced costs. Adequate oxygen transfer capacity was maintained during the scale-up, and strategies to increase further oxygen transfer rates (OTR) were explored, while maintaining favorable mixing parameters and low-stress conditions for sensitive lipid membrane-enclosed cells. Investigations from process development to the engineering properties of shaken bioreactors are underway, but the feasibility of establishing a robust, standardized, and transferable technical platform for mammalian cell culture based on orbital shaking and disposable materials has been established with further optimizations and studies ongoing.

Published
2009
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