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Esophageal pH-metric measurements are performed to assess the clinical relevance of gastroesophageal reflux (GER). They could be particularly useful for evaluating patients with typical GER symptoms in the absence of endoscopic and histologic evidence of esophagitis and patients with atypical symptoms. It has been shown, however, that the occurrence of GER may vary over time, being more frequently detected postprandially [1] and during the daytime [2]; it is possible that in these patients GER episodes may show marked variability on different days, and this variability may affect the reproducibility of the pH-metric measurements and, therefore, diagnostic conclusions of the tests.