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Your search keyword '"Lung toxicity"' showing total 17 results
Start Over Descriptor "Lung toxicity" Publisher springer berlin heidelberg
17 results on '"Lung toxicity"'

5. Characterization and in vivo toxicological evaluation of multi-walled carbon nanotubes: a low-dose repeated intratracheal administration study

Author

Bubols, Guilherme Borges, Arbo, Marcelo Dutra, Peruzzi, Caroline Portela, Cestonaro, Larissa Vivan, Altknecht, Louise Figueiredo, Fão, Nuryan, Göethel, Gabriela, Nascimento, Sabrina Nunes, Paese, Karina, Amaral, Marta Gonçalves, Bergmann, Carlos Pérez, Pohlmann, Adriana Raffin, Guterres, Silvia Stanisçuaski, and Garcia, Solange Cristina

Published
2023
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14. Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles

Author

Takamasa Numano, Akihiko Hirose, Katsumi Fukamachi, Jiegou Xu, Hideo Shimizu, Mitsuru Futakuchi, Hiroyuki Tsuda, Jun Kanno, Toyonori Omori, David B. Alexander, and Masumi Suzui

Subjects
Pathology, medicine.medical_specialty, Lung Neoplasms, Nitrosamines, Interstitial pneumonitis, Carcinogenicity Tests, Health, Toxicology and Mutagenesis, Nanosized zinc oxide particles, chemistry.chemical_element, Zinc, Toxicology, medicine.disease_cause, Proto-Oncogene Mas, Rats, Sprague-Dawley, Chlorides, Gene expression, medicine, Animals, Humans, Epithelial hyperplasia, Inorganic Compounds, Bronchioles, Lung toxicity, Lung, Hyperplasia, Chemistry, Epithelial Cells, General Medicine, medicine.disease, Rats, Epithelial hyperplasia of terminal bronchioles, Terminal Bronchioles, medicine.anatomical_structure, Genes, ras, Gene Expression Regulation, Zinc Compounds, Cancer research, Lung carcinogenesis, Nanoparticles, Lung fibrosis, Female, Rats, Transgenic, Zinc Oxide, Carcinogenesis, Lung Diseases, Interstitial
Abstract

Zinc oxide (ZnO) is known to induce lung toxicity, including terminal bronchiolar epithelial hyperplasia, which gives rise to concerns that nanosized ZnO (nZnO) might lead to lung carcinogenesis. We studied the tumor promoting activity of nZnO by an initiation–promotion protocol using human c-Ha-ras proto-oncogene transgenic rats (Hras128 rats). The rats were given 0.2 % N-nitrosobis(2-hydroxypropyl)amine (DHPN) in the drinking water for 2 weeks and then treated with 0.5 ml of 250 or 500 μg/ml nZnO suspension by intra-pulmonary spraying once every 2 weeks for a total of 7 times. Treatment with nZnO particles did not promote DHPN-induced lung carcinogenesis. However, nZnO dose-dependently caused epithelial hyperplasia of terminal bronchioles (EHTB) and fibrosis-associated interstitial pneumonitis (FAIP) that were independent of DHPN treatment. Tracing the fate of EHTB lesions in wild-type rats indicated that the hyperplastic lesions almost completely disappeared within 12 weeks after the last nZnO treatment. Since nZnO particles were not found in the lung and ZnCl2 solution induced similar lung lesions and gene expression profiles, the observed lesions were most likely caused by dissolved Zn2+. In summary, nZnO did not promote carcinogenesis in the lung and induced EHTB and FAIP lesions that regressed rapidly, probably due to clearance of surplus Zn2+ from the lung. Electronic supplementary material The online version of this article (doi:10.1007/s00204-013-1086-5) contains supplementary material, which is available to authorized users.

Published
2013

16. A Strategic Adjuvant Therapy of Osteosarcoma

Author

Jasmin, C., Allfrey, V. G., editor, Allgöwer, M., editor, Berenblum, I., editor, Bergel, F., editor, Bernard, J., editor, Bernhard, W., editor, Blokhin, N. N., editor, Bock, H. E., editor, Braun, W., editor, Bucalossi, P., editor, Chaklin, A. V., editor, Chorazy, M., editor, Cunningham, G. J., editor, Porta, G. Della, editor, Denoix, P., editor, Dulbecco, R., editor, Eagle, H., editor, Eker, R., editor, Good, R. A., editor, Grabar, P., editor, Harris, R. J. C., editor, Hecker, E., editor, Herbeuval, R., editor, Higginson, J., editor, Hueper, W. C., editor, Isliker, H., editor, Kieler, J., editor, Kirsten, W. H., editor, Klein, G., editor, Koprowski, H., editor, Koss, L. G., editor, Macbeth, R. A., editor, Martz, G., editor, Mathé, G., editor, Mühlbock, O., editor, Old, L. J., editor, Potter, V. R., editor, Sabin, A. B., editor, Sachs, L., editor, Saxén, E. A., editor, Schmidt, C. G., editor, Spiegelman, S., editor, Szybalski, W., editor, Tagnon, H., editor, Tissières, A., editor, Uehlinger, E., editor, Wissler, R. W., editor, Rentchnick, P., editor, Senn, H. J., editor, Bonadonna, G., editor, and Salmon, S., editor

Published
1982
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