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Regional disparities resulting, above all, from lasting disproportional location of industrial capacities, have shaped Slovakia’s development in recent years. The goal of the chapter is to map regional employment differentiation in the SR, according to high-tech and low-tech manufacturing sectors. To achieve this we worked with recent regional statistical data. We concentrated on this question: Does there exist a substantial relationship between location of high-tech manufacturing and employment growth in selected regions. According to our survey, the high-tech sector did not prove to have strong impact on total employment. However, considering the changing structure of manufacturing in the future, it will represent one of the most decisive issues concerning competitive growth.