Search

This paper analyzes what stylistic characteristics differentiate different styles of writing, and specifically types of different A-level computer science articles. To do so, we compared various full papers using stylistic feature sets and a supervised machine learning method. We report on the success of this approach in identifying papers from the last 6 years of the following three conferences: SIGIR, ACL, and AAMAS. This approach achieves high accuracy results of 95.86%, 97.04%, 93.22%, and 92.14% for the following four classification experiments: (1) SIGIR / ACL, (2) SIGIR / AAMAS, (3) ACL / AAMAS, and (4) SIGIR / ACL / AAMAS, respectively. The Part of Speech (PoS) and the Orthographic sets were superior to all others and have been found as key components in different types of writing.

In this paper we describe a machine vision approach to recognize the denomination classes of the Mexican paper currency by extracting their color features. A banknote's color is characterized by summing all the color vectors of the image's pixels to obtain a resultant vector, the banknote's denomination is classified by knowing the orientation of the resulting vector within the RGB space. In order to obtain a more precise characterization of paper currency, the less discriminative colors of each denomination are eliminated from the images; the color selection is applied in the RGB and HSV spaces, separately. Experimental results with the current Mexican banknotes are presented.

With the increasing of the amount of the scientific papers, it is very important and difficult for paper-sharing platforms to recommend related papers accurately for users. This paper tackles the problem by proposing a method that models user historical behavior. Through collecting the operations on scientific papers of online users and carrying on the detailed analysis, we build preference model for each user. The personalized recommendation model is constructed based on content-based filtering model and statistical language model.. Experimental results show that users’ historical behavior plays an important role in user preference modeling and the proposed method improves the final predication performance in the field of technical papers recommendation.

International audience; All modellers have come across, one day, one of these popular toy agent-based models (ABMs), like "Ants", for instance, which depicts the appearance of pheromone trails built by simulated ants. They are simple, but representative of the way "real", more complex, ABMs are designed: in addition to explicitly describe the individual entities used to represent the system, modellers make implicit references to abstractions corresponding to the emerging structures they are tracking in the simulations. Yet, these abstractions are not represented in the models themselves as first-class entities: they are either hidden in ex-post computations or only part of visualization tasks, as if an explicit representation could somehow damage the processes at work in their emergence. This clearly constitutes an obstacle to the development of multi-level models, where emergence is likely to occur at different levels of abstraction of the system: if some of these levels are not represented in the models, the emergence of higher-level structures is not likely to be observed. This paper describes a modelling language that allows a modeller to represent and specify emerging structures in agent-based models. Firstly, to ease the description, we present these structures and their properties in four toy ABMs: Schelling, Boids, Collective Sort and Ants. Then we define the operations that are needed to represent and specify them without sacrificing the properties of the original model. An implementation of these operations in the GAML modelling language (part of the GAMA agent-based platform) is then presented. Finally, two simulations of the Boids model are used to illustrate the expressivity of this language and the multiple advantages it brings in terms of analysis, visualization and modeling of multi-level ABMs.

A method is proposed to analyze the preferred Modulation Transfer Function (MTF) of printing medium like paper for the image quality of printing. First, the spectral intensity distribution of printed image is simulated by changing the MTF of medium. Next, the simulated image is displayed on a high-precision LCD to reproduce the appearance of printed image. An observer rating evaluation experiment is carried out to the displayed image to discuss what the preferred MTF is. The appearance simulation of printed image was conducted on particular printing conditions: several contents, ink colors, a halftoning method and a print resolution (dpi). The experiments on different printing conditions can be conducted since our simulation method is flexible about changing conditions.

The industrial design cycle starts with design then simulation, prototyping, and testing. When the tests do not match the design requirements the design process is started over again. It is important for students to experience this process before they leave their academic institution. The high cost of the prototype phase, due to CNC/Rapid Prototype machine costs, makes hands on study of this process expensive for students and the academic institutions. This document shows that the commercially available LEGO NXT Robot kit is a viable low cost surrogate to the expensive industrial CNC/Rapid Prototype portion of the industrial design cycle.

The main topic of the article is to give a detailed description of the new and promising quadtree decomposition texture analysis method used for paper formation determination. Paper formation or configuration of fibers, fines and fillers in the two-dimensional spatial xy-domain of the paper is a very important property and image analysis application for the paper industry. The basis of the method is the successive quadtree decomposition process resulting in a two-dimensional block partitioning of the formation structure image analysed. In this context the blocks represents a unit of variation, and the size of a quadtree block is controlled by a set of different parameters. In addition to the primary features detected by the algorithm, characterization of a large set of secondary features is performed, including gradient analysis and spatial distribution analysis.

This paper proposes a colored paper mosaic rendering technique based on image segmentation that can automatically generate a torn and tagged colored paper mosaic effect. The previous method[12] did not produce satisfactory results due to the ineffectiveness of having to use pieces of the same size. The proposed two methods for determination of paper shape and location that are based on segmentation can subdivide an image area by considering characteristics of image. The first method is to generate a Voronoi polygon after subdividing the segmented image again using a quad tree. And the second method is to apply the Voronoi diagram on each segmentation layer. Through these methods, the characteristic of the image is expressed in more detail than the previous colored paper mosaic rendering method.

Diagrams play an important role in human problem solving. In response to a challenging assignment, three students produced diagrams and subsequent verbal protocols that offer insight into human cognition. The diversity and richness of their response, and their ability to address the task via diagrams, provide an incisive look at the role diagrams play in the development of expertise. This paper recounts how their diagrams led and misled them, and how the diagrams both explained and drove explanation. It also considers how this process might be adapted for a computer program.

The automated supervision system for online teaching is volatile in current teaching observation. Hence, it requires additional comprehensive, analytical, and realistic discussion on how the automatic supervision method can be applied to high school teaching. This paper integrated remote supervision with machine learning algorithms (IRS-MLA) proposed for the online English teaching audit process. Here, IRS-MLA simulates the implementation of supervision methodologies in the teaching process according to English online teaching’s real needs. Furthermore, searching the performance and stating the learning process for students from the teachers’ perspectives and their students measures the teacher’s teaching process. This paper presents the studies for evaluating the classic English language online supervision and explores this method’s functional impact. This analysis’s findings show that the model developed in this paper worked well and validated based on the case study report. This study validates the proposed IRS-MLA with the highest performance ratio of 97.8%, the accuracy of 96%, the efficiency of 99.3%, and a success ratio of 98%, compared to existing models.

Improvement in cross-language information retrieval results can come from a variety of sources - failure analysis, resource enrichment in terms of stemming and parallel and comparable corpora, use of pivot languages, as well as phonetic transliteration and Romanization. Application of these methodologies should contribute to a gradual increase in the ability of search software to cross the language barrier.

Emerging intelligent environments are considered to offer significant opportunities to positively impact human life, both at an individual and at a societal level, and in particular to provide useful means to support people in their daily life activities and thus improve well-being for everybody, especially for older people and for people with limitations of activities. In this context, accessibility and usability, although necessary, are not sufficient to ensure that applications and services are appropriately designed to satisfy human needs and overcome potential functional limitations in the execution of everyday activities fundamental for well-being. This position paper puts forward the claim that, in order to achieve the above objective, it is necessary that: (i) the design of Assistive Intelligent Environments is centered around the well-being of people, roughly intended as the possibility of executing the (everyday) human activities necessary for living (independently), thus emphasizing usefulness in addition to usability; (ii) the technological environment is orchestrated around such activities and contains knowledge about how they are performed and how people need to be supported to perform them; (iii) the environment makes use of monitoring and reasoning capabilities in order to adapt, fine-tune and evolve over time the type and level of support provided, and this process takes place considering ethical values; (iv) the applications must also support the possibility of contact with other people, who in many cases may be the only effective help. Moving forward from the Design for All paradigm, this paper discusses how the latter can be revisited under the perspective of technology’s usefulness and contribution to human well-being. Subsequently, it introduces a practical notion of well-being based on the ICF classification of human functions and activities and discusses how such notion can constitute the starting point and the focus of design approaches targeted to assist people in their everyday life mainly (but not exclusively) in the home environment. As a subsequent step, the need for integrating Artificial Intelligence capabilities in assistive intelligent environments is discussed, based on the complexity of the human problems to be addressed and the diversity of the types of support needed. The proposed approach is exemplified and illustrated through the experience acquired in the development of four applications, addressing vital aspects of human life, namely nutrition, stress management, sleep management and counteracting loneliness. Finally, based on the acquired experience, the need to take into account ethical values in the development of assistive intelligent environments is discussed.

In the era of autonomous robots, multi-targets search methods inspired researchers to develop adapted algorithms to robot constraints, and with the rising of Swarm Intelligence (SI) approaches, Swarm Robotics (SRs) became a very popular topic. In this paper, the problem of searching for an exponentially increasing number of targets in a complex and unknown environment is addressed. Our main objective is to propose a Robotic target search strategy based on the EHO (Elephants Herding Optimization) algorithm, namely Robotic-EHO (REHO). The main additions were the collision-free path planning strategy, the velocity limitation, and the extension to the multi-target version in discrete environments. The proposed method has been the subject of many experiments, emulating the search of infected individuals by COVID-19 in a context of containment within complex and unknown random environments, as well as in the real case study of USA. The particularity of these environments is their increasing targets' number and the dynamic Containment Rate (CR) that we propose. The experimental results show that REHO reacts much better in high Containment Rate, early start search mission, and where the robots' speed is higher than the virus spread speed.

COVID-19 is an acronym for coronavirus disease 2019. Initially, it was called 2019-nCoV, and later International Committee on Taxonomy of Viruses (ICTV) termed it SARS-CoV-2. On 30th January 2020, the World Health Organization (WHO) declared it a pandemic. With an increasing number of COVID-19 cases, the available medical infrastructure is essential to detect the suspected cases. Medical imaging techniques such as Computed Tomography (CT), chest radiography can play an important role in the early screening and detection of COVID-19 cases. It is important to identify and separate the cases to stop the further spread of the virus. Artificial Intelligence can play an important role in COVID-19 detection and decreases the workload on collapsing medical infrastructure. In this paper, a deep convolutional neural network-based architecture is proposed for the COVID-19 detection using chest radiographs. The dataset used to train and test the model is available on different public repositories. Despite having the high accuracy of the model, the decision on COVID-19 should be made in consultation with the trained medical clinician.

In this paper, linear regression (LR), multi-linear regression (MLR) and polynomial regression (PR) techniques are applied to propose a model Li-MuLi-Poly. The model predicts COVID-19 deaths happening in the United States of America. The experiment was carried out on machine learning model, minimum mean square error model, and maximum likelihood ratio model. The best-fitting model was selected according to the measures of mean square error, adjusted mean square error, mean square error, root mean square error (RMSE) and maximum likelihood ratio, and the statistical t-test was used to verify the results. Data sets are analyzed, cleaned up and debated before being applied to the proposed regression model. The correlation of the selected independent parameters was determined by the heat map and the Carl Pearson correlation matrix. It was found that the accuracy of the LR model best-fits the dataset when all the independent parameters are used in modeling, however, RMSE and mean absolute error (MAE) are high as compared to PR models. The PR models of a high degree are required to best-fit the dataset when not much independent parameter is considered in modeling. However, the PR models of low degree best-fits the dataset when independent parameters from all dimensions are considered in modeling.

Engaging deep neural networks for textual sentiment analysis is an extensively practiced domain of research. Textual sentiment classification harnesses the full computational potential of deep learning models. Typically, these research works are carried either with a popular open-source data corpus, or self-extracted short phrase texts from Twitter, Reddit, or web-scrapped text data from other resources. Rarely do we see a large amount of data on a current ongoing event is being collected and cultured further. Also, an even more complex task would be to model the data from a currently ongoing event, not only for scaling the sentiment accuracy but also for making a predictive analysis for the same. In this paper, we propose a novel approach for achieving sentiment evaluation accuracy by using a deep neural network on live-streamed tweets on Coronavirus and future case growth prediction. We develop a large tweet corpus exclusively based on the Coronavirus tweets. We split the data into train and test sets, alongside we perform polarity classification and trend analysis. The refined outcome from the trend analysis helps to train the data to provide an incremental learning curvature for our neural network, and we obtain an accuracy of 90.67%. Finally, we provide a statistical-based future prediction for Coronavirus cases growth. Not only our model outperforms several previous state-of-art experiments in overall sentiment accuracy comparison for similar tasks, but it also maintains a throughout performance stability among all the test cases when tested with several popular open-source text corpora.

Deep reinforcement learning has the advantage of being able to encode fairly complex behaviors by collecting and learning empirical information. In the current study, we have proposed a framework for reinforcement learning in decentralized collision avoidance where each agent independently makes its decision without communication with others. In an environment exposed to various kinds of dynamic obstacles with irregular movements, mobile robot agents could learn how to avoid obstacles and reach a target point efficiently. Moreover, a path planner was integrated with the reinforcement learning-based obstacle avoidance to solve the problem of not finding a path in a specific situation, thereby imposing path efficiency. The robots were trained about the policy of obstacle avoidance in environments where dynamic characteristics were considered with soft actor critic algorithm. The trained policy was implemented in the robot operating system (ROS), tested in virtual and real environments for the differential drive wheel robot to prove the effectiveness of the proposed method. Videos are available at https://youtu.be/xxzoh1XbAl0 .

Assessing the current Artificial intelligence (AI) situation is a crucial step towards its implementation into radiology practice. The study aimed to assess radiographer willingness to accept AI in radiology work practice and the impact of AI in work performance. An exploratory cross-sectional online survey conducted for radiographers working within the Middle East and India was conducted from May–August 2020. A previously validated survey used to obtain radiographer's demographics, knowledge, perceptions, organization readiness, and challenges of integrating AI into radiology. The survey was accessible for radiographers and distributed through the societies page. The survey was completed by 549 radiographers distributed as (77.6%, n = 426) from the Middle East while (22.4%, n = 123) from India. A majority (86%, n = 773) agreed that AI currently plays an important role in radiology and (88.0%, n = 483) expected that AI would play a role in radiology practice and image production. The challenges for AI implementation in practice were developing AI skills (42.8%, n = 235) and AI knowledge development (37.0%, n = 203). Participants showed high interest to integrate AI in under and postgraduate curriculum. There is excitement about what AI could offer, but education input is a requirement. Fears are expressed about job security and how radiology may work across all ages and educational backgrounds. Radiographers become aware of AI role and challenges, which can be improved by education and training.

Study of the neural code for space in rodents has many insights to offer for how mammals, including humans, construct a mental representation of space. This code is centered on the hippocampal place cells, which are active in particular places in the environment. Place cells are informed by numerous other spatial cell types including grid cells, which provide a signal for distance and direction and are thought to help anchor the place cell signal. These neurons combine self-motion and environmental information to create and update their map-like representation. Study of their activity patterns in complex environments of varying structure has revealed that this "cognitive map" of space is not a fixed and rigid entity that permeates space, but rather is variably affected by the movement constraints of the environment. These findings are pointing toward a more flexible spatial code in which the map is adapted to the movement possibilities of the space. An as-yet-unanswered question is whether these different forms of representation have functional consequences, as suggested by an enactivist view of spatial cognition.

Digital technologies are transforming human relations, interactions and experiences in the business landscape. Whilst a great potential of artificial intelligence (AI) in the service industries is predicted, the concrete influence of AI on customer experiences remains little understood. Drawing upon the service-dominant (SD) logic as a theoretical lens and a scenario technique approach, this study explores the impact of artificial intelligence as an operant resource on event experiences. The findings offer a conceptualisation of three distinct future scenarios for the year 2026 that map out a spectrum of experiences from value co-creation to value co-destruction of events. The paper makes a theoretical contribution in that it bridges marketing, technology and experience literature, and zooms in on AI as a non-human actor of future experience life ecosystems. A practical guideline for event planners is offered on how to implement AI across each touch point of the events ecosystem.

We present new data analytics-based predictions results that can help governments to plan their future actions and also help medical services to be better prepared for the future. Our system can predict new corona cases with 99.82% accuracy using susceptible infected recovered (SIR) model. We have predicted the results of new COVID cases per day for dense and highly populated country i.e. India. We found that traditional statistical methods will not work efficiently as they do not consider the limited population in a particular country. Using the data analytics-based curve we predicted four most likely possibilities for the number of new cases in India. Hence, we expect that the results mentioned in the manuscript help people to better understand the progress of this disease. Supplementary Information The online version contains supplementary material available at 10.1007/s12065-021-00600-2.

Coronavirus is a fatal disease that affects mammals and birds. Usually, this virus spreads in humans through aerial precipitation of any fluid secreted from the infected entity's body part. This type of virus is fatal than other unpremeditated viruses. Meanwhile, another class of coronavirus was developed in December 2019, named Novel Coronavirus (2019-nCoV), first seen in Wuhan, China. From January 23, 2020, the number of affected individuals from this virus rapidly increased in Wuhan and other countries. This research proposes a system for classifying and analyzing the predictions obtained from symptoms of this virus. The proposed system aims to determine those attributes that help in the early detection of Coronavirus Disease (COVID-19) using the Adaptive Neuro-Fuzzy Inference System (ANFIS). This work computes the accuracy of different machine learning classifiers and selects the best classifier for COVID-19 detection based on comparative analysis. ANFIS is used to model and control ill-defined and uncertain systems to predict this globally spread disease's risk factor. COVID-19 dataset is classified using Support Vector Machine (SVM) because it achieved the highest accuracy of 100% among all classifiers. Furthermore, the ANFIS model is implemented on this classified dataset, which results in an 80% risk prediction for COVID-19.

Graphical abstract Most drugs are no longer produced in their own countries by the pharmaceutical companies, but by contract manufacturers or at manufacturing sites in countries that can produce more cheaply. This not only makes it difficult to trace them back but also leaves room for criminal organizations to fake them unnoticed. For these reasons, it is becoming increasingly difficult to determine the exact origin of drugs. The goal of this work was to investigate how exactly this is possible by using different spectroscopic methods like nuclear magnetic resonance and near- and mid-infrared spectroscopy in combination with multivariate data analysis. As an example, 56 out of 64 different paracetamol preparations, collected from 19 countries around the world, were chosen to investigate whether it is possible to determine the pharmaceutical company, manufacturing site, or country of origin. By means of suitable pre-processing of the spectra and the different information contained in each method, principal component analysis was able to evaluate manufacturing relationships between individual companies and to differentiate between production sites or formulations. Linear discriminant analysis showed different results depending on the spectral method and purpose. For all spectroscopic methods, it was found that the classification of the preparations to their manufacturer achieves better results than the classification to their pharmaceutical company. The best results were obtained with nuclear magnetic resonance and near-infrared data, with 94.6%/99.6% and 98.7/100% of the spectra of the preparations correctly assigned to their pharmaceutical company or manufacturer. Supplementary Information The online version contains supplementary material available at 10.1007/s00216-021-03249-z.

For advanced tongue cancer, the choice between surgery and organ-sparing treatment is often dependent on the expected loss of tongue functionality after treatment. Biomechanical models might assist in this choice by simulating the post-treatment function loss. However, this function loss varies between patients and should, therefore, be predicted for each patient individually. In the present study, the goal was to better predict the postoperative range of motion (ROM) of the tongue by personalizing biomechanical models using diffusion-weighted MRI and constrained spherical deconvolution reconstructions of tongue muscle architecture. Diffusion-weighted MRI scans of ten healthy volunteers were obtained to reconstruct their tongue musculature, which were subsequently registered to a previously described population average or atlas. Using the displacement fields obtained from the registration, the segmented muscle fiber tracks from the atlas were morphed back to create personalized muscle fiber tracks. Finite element models were created from the fiber tracks of the atlas and those of the individual tongues. Via inverse simulation of a protruding, downward, left and right movement, the ROM of the tongue was predicted. This prediction was compared to the ROM measured with a 3D camera. It was demonstrated that biomechanical models with personalized muscles bundles are better in approaching the measured ROM than a generic model. However, to achieve this result a correction factor was needed to compensate for the small magnitude of motion of the model. Future versions of these models may have the potential to improve the estimation of function loss after treatment for advanced tongue cancer.

Potamotrygon motoro has been shown to use vision to orient in a laboratory setting and has been successfully trained in cognitive behavioral studies using visual stimuli. This study explores P. motoro’s visual discrimination abilities in the context of two-alternative forced-choice experiments, with a focus on shape and contrast, stimulus orientation, and visual resolution. Results support that stingrays are able to discriminate stimulus-presence and -absence, overall stimulus contrasts, two forms, horizontal from vertical stimulus orientations, and different colors that also vary in brightness. Stingrays tested in visual resolution experiments demonstrated a range of visual acuities from

Purpose Accurately forecasting the occurrence of future covid-19-related cases across relaxed (Sweden) and stringent (USA and Canada) policy contexts has a renewed sense of urgency. Moreover, there is a need for a multidimensional county-level approach to monitor the second wave of covid-19 in the USA. Method We use an artificial intelligence framework based on timeline of policy interventions that triangulated results based on the three approaches—Bayesian susceptible-infected-recovered (SIR), Kalman filter, and machine learning. Results Our findings suggest three important insights. First, the effective growth rate of covid-19 infections dropped in response to the approximate dates of key policy interventions. We find that the change points for spreading rates approximately coincide with the timelines of policy interventions across respective countries. Second, forecasted trend until mid-June in the USA was downward trending, stable, and linear. Sweden is likely to be heading in the other direction. That is, Sweden’s forecasted trend until mid-June appears to be non-linear and upward trending. Canada appears to fall somewhere in the middle—the trend for the same period is flat. Third, a Kalman filter based robustness check indicates that by mid-June the USA will likely have close to two million virus cases, while Sweden will likely have over 44,000 covid-19 cases. Conclusion We show that drop in effective growth rate of covid-19 infections was sharper in the case of stringent policies (USA and Canada) but was more gradual in the case of relaxed policy (Sweden). Our study exhorts policy makers to take these results into account as they consider the implications of relaxing lockdown measures.

BackgroundOptimal detection and surveillance of bladder cancer (BCa) rely primarily on the cystoscopic visualization of bladder lesions. AI-assisted cystoscopy may improve image recognition and accelerate data acquisition.ObjectiveTo provide a comprehensive review of machine learning (ML), deep learning (DL) and convolutional neural network (CNN) applications in cystoscopic image recognition.Evidence acquisitionA detailed search of original articles was performed using the PubMed-MEDLINE database to identify recent English literature relevant to ML, DL and CNN applications in cystoscopic image recognition.Evidence synthesisIn total, two articles and one conference abstract were identified addressing the application of AI methods in cystoscopic image recognition. These investigations showed accuracies exceeding 90% for tumor detection; however, future work is necessary to incorporate these methods into AI-aided cystoscopy and compared to other tumor visualization tools. Furthermore, we present results from the RaVeNNA-4pi consortium initiative which has extracted 4200 frames from 62 videos, analyzed them with the U-Net network and achieved an average dice score of 0.67. Improvements in its precision can be achieved by augmenting the video/frame database.ConclusionAI-aided cystoscopy has the potential to outperform urologists at recognizing and classifying bladder lesions. To ensure their real-life implementation, however, these algorithms require external validation to generalize their results across other data sets.

Strategies used in artificial grammar learning can shed light into the abilities of different species to extract regularities from the environment. In the A(X)nB rule, A and B items are linked but assigned to different positional categories and separated by distractor items. Open questions are how widespread is the ability to extract positional regularities from A(X)nB patterns, which strategies are used to encode positional regularities and whether individuals exhibit preferences for absolute or relative position encoding. We used visual arrays to investigate whether cotton-top tamarins (Saguinus oedipus) can learn this rule and which strategies they use. After training on a subset of exemplars, half of the tested monkeys successfully generalized to novel combinations. These tamarins discriminated between categories of tokens with different properties (A, B, X) and detected a positional relationship between non-adjacent items even in the presence of novel distractors. Generalization, though, was incomplete, since we observed a failure with items that during training had always been presented in reinforced arrays. The pattern of errors revealed that successful subjects used visual similarity with training stimuli to solve the task, and that tamarins extracted the relative position of As and Bs rather than their absolute position, similarly to what observed in other species. Relative position encoding appears to be the default strategy in different tasks and taxa.

Shortly after deep learning algorithms were applied to Image Analysis, and more importantly to medical imaging, their applications increased significantly to become a trend. Likewise, deep learning applications (DL) on pulmonary medical images emerged to achieve remarkable advances leading to promising clinical trials. Yet, coronavirus can be the real trigger to open the route for fast integration of DL in hospitals and medical centers. This paper reviews the development of deep learning applications in medical image analysis targeting pulmonary imaging and giving insights of contributions to COVID-19. It covers more than 160 contributions and surveys in this field, all issued between February 2017 and May 2020 inclusively, highlighting various deep learning tasks such as classification, segmentation, and detection, as well as different pulmonary pathologies like airway diseases, lung cancer, COVID-19 and other infections. It summarizes and discusses the current state-of-the-art approaches in this research domain, highlighting the challenges, especially with COVID-19 pandemic current situation.

Root cause analysis (RCA) is one of the most prominent tools used to comprehensively evaluate a biopharmaceutical production process. Despite of its widespread use in industry, the Food and Drug Administration has observed a lot of unsuitable approaches for RCAs within the last years. The reasons for those unsuitable approaches are the use of incorrect variables during the analysis and the lack in process understanding, which impede correct model interpretation. Two major approaches to perform RCAs are currently dominating the chemical and pharmaceutical industry: raw data analysis and feature-based approach. Both techniques are shown to be able to identify the significant variables causing the variance of the response. Although they are different in data unfolding, the same tools as principal component analysis and partial least square regression are used in both concepts. Within this article we demonstrate the strength and weaknesses of both approaches. We proved that a fusion of both results in a comprehensive and effective workflow, which not only increases better process understanding. We demonstrate this workflow along with an example. Hence, the presented workflow allows to save analysis time and to reduce the effort of data mining by easy detection of the most important variables within the given dataset. Subsequently, the final obtained process knowledge can be translated into new hypotheses, which can be tested experimentally and thereby lead to effectively improving process robustness.