1. The Attitudes of Brazilian Breast Surgeons on Axillary Management in Early Breast Cancer-10 Years after the ACOSOG Z0011 Trial First Publication.
- Author
-
Millen EC, Cavalcante FP, Zerwes F, Novita G, de Souza ABA, Reis JHP, de Oliveira Filho HR, de B L Limongi LN, de Assis Carvalho BPS, de Oliveira Freitas AM, Jourdan MT, de Oliveira VM, and Freitas-Junior R
- Subjects
- Attitude, Axilla, Brazil, Clinical Trials as Topic, Female, Humans, Lymph Node Excision, Lymph Nodes surgery, Lymphatic Metastasis, Mastectomy, Mastectomy, Segmental, Middle Aged, Sentinel Lymph Node Biopsy, Breast Neoplasms surgery, Surgeons
- Abstract
Purpose: To evaluate the impact of the ACOSOG Z0011 trial on axillary breast cancer surgery management in Brazil following publication of that study (2010) and again in 2020., Patients and Methods: A survey of members of the Brazilian Society of Mastology., Results: Of 1627 breast surgeons, 799 (49.1%) completed and returned the questionnaire. For patients with the Z11 inclusion criteria, following detection of a positive sentinel lymph node (SLN), axillary dissection (AD) was recommended by 99.2% of respondents before publication of the study, 47.5% in 2010 and 18.5% in 2020 (p < 0.001). In breast-conserving surgery, if there were micro-metastases, 2.6% would perform AD, 30.3% axillary radiotherapy, and 67.1% no additional axillary treatment, while with macro-metastases, these proportions were 21.3%, 52.2%, and 26.5%, respectively. In cases of mastectomy and of nodal extracapsular extension, 43.4% and 36% of surgeons, respectively, recommended AD. For clinically negative axilla and suspicious findings at ultrasonography, 69% of the surgeons would apply the Z11 approach. Most applied the Z11 criteria in cases of younger patients (83.6%) and triple-negative and/or HER2 positive tumors (74%). AD was significantly more likely to be recommended by surgeons who did not work in academic institutes, who worked in locations other than capital cities, who were not board-certified, and who were ≥ 50 years old., Conclusions: This survey revealed substantial changes in axillary surgery management in cN0/pathologically positive SLN, particularly following publication of the updated Z11 results and other similar studies. A better education environment and long-term follow-up were factors associated with the incorporation of Z11-related changes in practice., (© 2021. Society of Surgical Oncology.)
- Published
- 2022
- Full Text
- View/download PDF