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Your search keyword '"Zaykovskaya AV"' showing total 4 results
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4 results on '"Zaykovskaya AV"'

1. Use of Adjuvant Compositions Based on Squalene Ensures Induction of Neutralizing Antibodies against SARS-CoV-2.

Author

Volosnikova EA, Volkova NV, Ermolaev VV, Borgoyakova MB, Nesmeyanova VS, Zaykovskaya AV, Pyankov OV, Zaitsev BN, Belenkaya SV, Isaeva AA, and Shcherbakov DN

Subjects
Animals, Mice, COVID-19 Vaccines immunology, Female, Humans, Mice, Inbred BALB C, Immunity, Humoral drug effects, Squalene immunology, Antibodies, Neutralizing immunology, Adjuvants, Immunologic pharmacology, SARS-CoV-2 immunology, Antibodies, Viral immunology, Antibodies, Viral blood, Spike Glycoprotein, Coronavirus immunology, COVID-19 immunology, COVID-19 virology
Abstract

Squalene-based adjuvant compositions that can provide effective induction of specific humoral immune response have been developed. Recombinant receptor-binding domain (RBD) of surface S-protein of SARS-CoV-2 was used to evaluate the properties of the composition. Immunization of mice with the developed squalene-based compositions in combination with RBD allows obtaining high titers of specific antibodies: from 10 5 to 2×10 6 . The blood sera from immunized mice exhibit neutralizing activity against SARS-CoV-2 Delta variant (B.1.617.2) with a titer up to 1:2000., (© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2024
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2. Immunogenicity of the DNA/Protein Combined Vaccine against COVID-19.

Author

Borgoyakova MB, Karpenko LI, Merkulyeva IA, Shcherbakov DN, Rudometov AP, Starostina EV, Shanshin DV, Isaeva AA, Nesmeyanova VS, Volkova NV, Belenkaya SV, Volosnikova EA, Zadorozhny AM, Orlova LA, Zaykovskaya AV, Pyankov OV, Bazhan SI, and Ilyichev AA

Subjects
Humans, COVID-19 Vaccines genetics, COVID-19 Vaccines therapeutic use, SARS-CoV-2, Pandemics, Vaccines, Combined, DNA, Antibodies, Viral, COVID-19 prevention & control, Vaccines, DNA genetics
Abstract

During the COVID-19 pandemic, the development of prophylactic vaccines, including those based on new platforms, became highly relevant. One such platform is the creation of vaccines combining DNA and protein components in one construct. For the creation of DNA vaccine, we chose the full-length spike protein (S) of the SARS-CoV-2 virus and used the recombinant receptor-binding domain (RBD) of the S protein produced in CHO-K1 cells as a protein component. The immunogenicity of the developed combined vaccine and its individual components was compared and the contribution of each component to the induction of the immune response was analyzed. The combined DNA/protein vaccine possesses the advantages of both underlying approaches and is capable of inducing both humoral (similar to subunit vaccines) and cellular (similar to DNA vaccines) immunity., (© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2022
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3. Pathogenesis of infectious disease of mice caused by H5N1 avian influenza virus.

Author

Evseenko VA, Sharshov KA, Bukin EK, Zaykovskaya AV, Ternovoy VA, Ignatyev GM, Shestopalov AM, Netesov SV, Shkurupiy VA, and Drozdov IG

Subjects
Animals, Base Sequence, Hemagglutinins genetics, Influenza A Virus, H5N1 Subtype genetics, Influenza A Virus, H5N1 Subtype metabolism, Interferon-gamma metabolism, Interleukin-10 metabolism, Interleukin-12 metabolism, Interleukin-1beta metabolism, Interleukin-6 metabolism, Mice, Mice, Inbred BALB C, Neuraminidase genetics, RNA-Dependent RNA Polymerase genetics, Tumor Necrosis Factor-alpha metabolism, Viral Matrix Proteins chemistry, Viral Proteins genetics, Influenza A Virus, H5N1 Subtype pathogenicity, Orthomyxoviridae Infections pathology, Orthomyxoviridae Infections virology
Abstract

The pathogenesis of a disease caused by Qinghai-like H5N1 influenza virus in BALB/c mice was studied. Clinical, morphological, and immunological characteristics of the experimental infection caused by highly pathogenic A/duck/Tuva/01/06/ (H5N1) virus are described.

Published
2008
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4. Studying the pathogenicity of avian influenza virus subtype H5N1 strains from the Russian Federation using mouse model.

Author

Shestopalov AM, Sharshov KA, Zaykovskaya AV, Rassadkin YN, Drozdov IG, Shkurupy VA, Potapova OV, and Luzgina NG

Subjects
Animals, Brain virology, Cytokines metabolism, Influenza A Virus, H5N1 Subtype growth & development, Kidney virology, Liver virology, Lung virology, Mice, Orthomyxoviridae Infections mortality, Spleen virology, Influenza A Virus, H5N1 Subtype pathogenicity
Abstract

The pathogenicity of strains of avian influenza virus subtype H5N1 from the Russian Federation (A/turkey/Suzdalka/12/05, A/goose/Krasnoozerskoye/627/05, A/duck/Tuva/01/06, A/chicken/Reshoty/02/06, and A/chicken/Krasnodar/123/060) was studied in mice. Morphological and immunological characteristics of experimental viral infection with avian influenza virus subtype H5N1 were evaluated.

Published
2008
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