1. The influence of uremia on the accessibility of phosphomycin into interstitial tissue fluid.
- Author
-
Fernandez Lastra C, Mariño EL, Dominguez-Gil A, Tabernero JM, Gonzalez Lopez A, and Yuste Chaves M
- Subjects
- Adult, Anti-Bacterial Agents administration & dosage, Creatinine metabolism, Female, Fosfomycin administration & dosage, Half-Life, Humans, Kinetics, Male, Metabolic Clearance Rate, Middle Aged, Anti-Bacterial Agents metabolism, Extracellular Space metabolism, Fosfomycin metabolism, Uremia metabolism
- Abstract
The entry and persistence of phosphomycin in interstitial tissue fluid (ITF) were studied in 9 patients with normal renal function and 8 patients with varying degrees of renal impairment, all of whom received a single i.v. dose of 30 mg/kg. ITF was obtained from skin blisters produced by suction. The antibiotic followed a two-compartment open kinetic model. In patients with normal renal function, phosphomycin is incorporated rapidly into the ITF reaching a level of 60.4 micrograms/ml 60 min after administration. There was no statistically significant difference between the elimination rates from serum and ITF. The serum half-life of the slow disposition phase was 1.75 h in patients with normal renal function. There was a linear correlation between the elimination half-life of phosphomycin in serum and ITF in subjects with differing degrees of renal impairment.
- Published
- 1983
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