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Monitoring of the adequacy of myocardial protection with cardioplegia is nearly non-existent in clinical cardiac surgical practice and instead relies on well-defined protocols for delivery of cardioplegia often resulting in inadequate protection. We hypothesized that Near Infrared Spectroscopy technology could be useful in the monitoring of the myocardial oxygen state by attaching the monitors to the epicardium in a porcine model of cardiac surgery. The experiments were conducted with 3 different protocols of 2 pigs each for a total of 6 pigs. The objective was to induce episodic, oxygen supply-demand mismatch. Methods for decreased supply included decreasing coronary blood flow, coronary blood hypoxemia, coronary occlusion, hypovolemia, and hypotension. Methods for increase demand included rapid ventricular pacing and the administration of isoproterenol. Changes in myocardial tissue oximetry were measured and this measurement was then correlated with blood hemoglobin saturations of oxygen from coronary sinus blood samples. We found that decreases in myocardial oxygen supply or increases in demand due to any of the various experimental conditions led to decreases in both myocardial tissue oximetry and hemoglobin oxygen saturation of coronary sinus blood with recovery when the conditions were returned to baseline. Correlation between myocardial tissue oximetry and hemoglobin oxygen saturation of coronary sinus blood was moderate to strong under all tested conditions. This may have translational applications as a monitor of adequacy of myocardial protection and the detection of coronary occlusion., (© 2020. Springer Nature B.V.)

Darker skin pigmentation appears to cause underestimation of regional oxygen saturation (rSO 2 ) for certain cerebral oximetry devices. This presents a risk of triggering unindicated interventions and may limit its utility for predicting adverse outcomes. Our goal was to quantify the impact of self-reported race on oximetry measurements during cardiac surgery and elucidate whether race has a mediating role in the association of rSO 2 with mortality. Data was extracted from our department's data warehouse for adult patients who underwent on-pump cardiac surgery between June 2014 and June 2018. Intraoperative rSO 2 was recorded every 15 s throughout all cases. After grouping patients by self-reported race, multiple linear regression modeling was utilized to assess the association between race and mean pre-bypass rSO 2 while controlling for various perioperative variables. The role of mean pre-bypass rSO 2 for predicting 30-day mortality was evaluated via multiple logistic regression, and the threshold for rSO 2 was selected by maximizing F1 score. There were 4267 patients included. Compared to Caucasian patients, the unadjusted difference in mean pre-bypass rSO 2 was - 0.6% (95% CI - 1.3 to 0.04) for African American patients, - 1.8% (- 2.7 to - 0.9) for Asian patients, 0.1% (- 0.8 to 1.0) for Hispanic patients, - 1.6% (- 3.0 to - 0.4) for Indian/South Asian patients, and - 1.4% (- 3.7 to 0.9) for Pacific Islander patients. After adjusting for perioperative variables, differences in rSO 2 readings less than 2% were observed between racial groups. Mean pre-bypass rSO 2 under 63% was an independent predictor of higher 30-day mortality risk (OR: 2.86, CI 1.39 to 5.53, p = 0.003), and the interaction variable between rSO 2 and race was not statistically significant (p = 0.299). Cerebral oximetry measurements are more consistent across racial groups than previously reported, supporting its utility for intraoperative monitoring and risk stratification. Pre-intervention rSO 2 is associated with increased 30-day mortality at a higher threshold than previously reported and was not significantly impacted by self-reported race.