1. High maternal vitamin D levels in early pregnancy may protect against behavioral difficulties at preschool age
- Author
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Mariza Kampouri, Stathis Papavasiliou, Georgia Chalkiadaki, Manolis Kogevinas, Andriani Kyriklaki, Vasiliki Daraki, Leda Chatzi, Katerina Margetaki, Katerina Koutra, Marina Vafeiadi, Marianna Katrinaki, Theano Roumeliotaki, RS: NUTRIM - R3 - Respiratory & Age-related Health, Complexe Genetica, and RS: NUTRIM - R4 - Gene-environment interaction
- Subjects
Adult ,Male ,BRAIN-DEVELOPMENT ,medicine.medical_specialty ,Pediatrics ,Mothers ,NEUROCOGNITIVE DEVELOPMENT ,030209 endocrinology & metabolism ,Affect (psychology) ,SERUM ,Cohort Studies ,CHEMICALS ,03 medical and health sciences ,D DEFICIENCY ,0302 clinical medicine ,Cognition ,Pregnancy ,Behavior problems ,Developmental and Educational Psychology ,medicine ,Child and adolescent psychiatry ,Animals ,Humans ,Attention deficit hyperactivity disorder ,ADHD ,Prospective Studies ,030212 general & internal medicine ,Vitamin D ,Child ,Prenatal vitamins ,RISK ,OUTCOMES ,Greece ,D-3 ,Confounding ,Preschool children ,Brain ,General Medicine ,Strengths and Difficulties Questionnaire ,medicine.disease ,25-hydroxyvitamin D ,ADULT BRAIN ,Psychiatry and Mental health ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Cohort ,Female ,Psychology - Abstract
Animal studies suggest that prenatal vitamin D status may affect fetal brain growth. However, human studies are scarce with conflicting results. We aimed to investigate the association of maternal 25-hydroxyvitamin D [25(OH) D] levels with multiple neurodevelopmental outcomes at 4 years of age. We included 487 mother–child pairs from the prospective pregnancy cohort, “Rhea” in Crete, Greece. Maternal serum 25(OH) D concentrations were measured at the first prenatal visit (13 ± 2.4 weeks). Cognitive functions at 4 years were assessed by means of the McCarthy Scales of Children’s Abilities. Behavioral difficulties were assessed by means of Strengths and Difficulties Questionnaire and Attention Deficit Hyperactivity Disorder Test. Children of women in the high 25(OH) D tertile (>50.7 nmol/l) had 37% decreased number of hyperactivity–impulsivity symptoms (IRR 0.63, 95% CI 0.39, 0.99, p trend = 0.05) and 40% decreased number of total ADHD-like symptoms (IRR 0.60, 95% CI 0.37, 0.95, p trend = 0.03) at 4 years of age, compared to children of women in the low 25(OH) D tertile (
- Published
- 2018