1. Quantitative evaluation of 2-deoxy-2[F-18]fluoro-D-glucose-positron emission tomography imaging on the woodchuck model of hepatocellular carcinoma with histological correlation.
- Author
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Salem N, MacLennan GT, Kuang Y, Anderson PW, Schomisch SJ, Tochkov IA, Tennant BC, and Lee Z
- Subjects
- Animals, Hepatitis B Virus, Woodchuck pathogenicity, Liver Neoplasms, Experimental virology, Marmota, Models, Statistical, Positron-Emission Tomography statistics & numerical data, Fluorine Radioisotopes, Fluorodeoxyglucose F18, Liver Neoplasms, Experimental diagnostic imaging, Liver Neoplasms, Experimental pathology, Positron-Emission Tomography methods, Radiopharmaceuticals
- Abstract
Purpose: The Eastern woodchuck (Marmota monax) is considered as a naturally occurring animal model of hepatocellular carcinoma (HCC). The performance of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) for imaging HCC on the woodchuck using Positron emission tomography (PET) was investigated in this study., Procedures: Dynamic FDG-PET scans were performed on five woodchucks with HCC and one healthy woodchuck before removal and processing of the liver tissues for histology. The parameters of a two-tissue compartment model with dual input were estimated using weighted least squares (WLS)., Results: Ten HCCs were confirmed histologically. Six HCCs had a tumor-to-liver standardized uptake value (SUV) ratio < or =1.15, a k (4) / k (3) ratio similar to that in hepatic tissues and were well-differentiated. Four HCCs had a tumor-to-liver SUV ratio >1.15, a lower k (4) / k (3) ratio than the hepatic tissues and were moderately differentiated., Conclusions: Increased FDG uptake was observed in HCCs that were the least differentiated and correlated with a lower k (4) / k (3) ratio.
- Published
- 2007
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