1. Anodic stripping voltammetric determination of vardenafil hydrochloride at pencil graphite electrode
- Author
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Merve Yaşacan, Serdar Abaci, Yesim Tugce Yaman, Tamer Çırak, Zehra Yazar Aydın, [Aydin, Zehra Yazar -- Yasacan, Merve] Hacettepe Univ, Grad Sch Sci & Engn, Nanotechnol & Nanomed Dept, Ankara, Turkey -- [Yaman, Yesim Tugce] Hacettepe Univ, Grad Sch Sci & Engn, Dept Chem, Ankara, Turkey -- [Cirak, Tamer] Aksaray Univ, Vocat Sch Tech Sci, Alternat Energy Sources Div, Aksaray, Turkey -- [Abaci, Serdar] Hacettepe Univ, Dept Chem, Fac Sci, Ankara, Turkey, CIRAK, Tamer -- 0000-0003-0431-9919, Aksaray Teknik Bilimler Meslek Yüksekokulu, and Çırak, Tamer -- 0000-0003-0431-9919
- Subjects
Detection limit ,Pencil graphite electrode ,Vardenafil hydrochloride ,Chromatography ,Stripping (chemistry) ,Chemistry ,Hydrochloride ,010401 analytical chemistry ,Analytical chemistry ,02 engineering and technology ,General Chemistry ,021001 nanoscience & nanotechnology ,Electrochemistry ,01 natural sciences ,0104 chemical sciences ,Anode ,chemistry.chemical_compound ,Analytical methods ,Calibration ,Voltammetry ,Kinetic parameters ,0210 nano-technology ,Selectivity - Abstract
WOS: 000394372500007, In this paper, we present a very popular and low-cost sensor material as disposable pencil graphite electrode (PGE) system for the trace-level determination of vardenafil hydrochloride (VRL). Electrochemical behavior and determination of VRL was carried out by cyclic and square-wave adsorptive anodic stripping (SW-AdAS) voltammetry. The proposed method was highly sensitive and had a linear calibration range from 3 x 10(-10) to 1 x 10(-7) M with a correlation coefficient of 0.997. The limit of detection and limit of quantitation values were calculated as 1 x 10(-10) and 3 x 10(-10) M, respectively. Developed method with disposable PGE shows high sensitivity, selectivity and stability in a wide concentration range for VRL determination without the necessity of any modification. Additionally, this system was successfully applied in Levitra(A (R)) tablets and spiked human serum in trace level of VRL. Some kinetic parameters of VRL's were represented for the first time. The results showed that the proposed method is highly sensitive, easy and low cost for trace-level determination of VRL.
- Published
- 2017