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1. Effect of melatonin on induction of ovulation in the light- induced constant estrous-anovulatory syndrome and possible role of the brain serotoninergic system.

Author

Trentini GP, Mess B, De Gaetani CF, and Ruzsás C

Subjects
Animals, Estrus drug effects, Estrus radiation effects, Female, Light, Melatonin therapeutic use, Methiothepin pharmacology, Ovulation radiation effects, Pineal Gland radiation effects, Pregnancy, Rats, Tryptophan deficiency, Anovulation drug therapy, Melatonin pharmacology, Ovulation drug effects, Receptors, Serotonin drug effects
Abstract

Continuous light (CL) induces constant estrous anovulatory (CEA) syndrome and blockade of pineal gland activity. Chronic treatment with metatonin is able to overcome the anovulatory state in about 70% of CL-CEA rats, and the luteinizing effect of melatonin is significantly counteracted either by feeding the animals with a tryptophan-poor diet or by injecting methiothepin, a blocker of central serotoninergic receptors. It appears that melatonin elicits luteinization in CL-CEA rats through the brain serotoninergic system.

Published
1978
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