1. Safety of nonsteroidal anti-inflammatory drugs in major gastrointestinal surgery: a prospective, multicenter cohort study
- Author
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Denise Osei-Kuffour, Rahul Bhome, Charn Gill, Oliver Ziff, Ali Bakhsh, Damien Brown, DEVENDER MITTAPALLI, Hayden McRobbie, Dafydd Loughran, Roshni Bhudia, Christopher Graham, John Bassett, Dermot Burke, Guy Stanley, Richard Egan, Michael Stoddart, James Fitzgerald, Thomas Lorchan Lewis, Bryan Traynor, Robert Whitham, Hannah Charlotte Copley, Shaine Morris, Fraser Peck, Chetan Khatri, Rupert Pearse, Christine McGarrigle, Charlotte Holmes, Nicholas Bullock, Adam Boulton, Shyam Gokani, Nicholas John Sebastian Chilvers, Peng Yong Sim, Siyin Liu, Dominic Marshall, Laura Wingfield, Darren Mc Cormack, Angeline Lee, Inge Bernstein, Marie Edison, Babatunde Oremule, Daniel McAuley, STARSurg Collaborative, Joshua Burke, James Glasbey, DR DEVINA MARU, Rebecca Reid, Michael Greshan Rasiah, Ossama Al-Obaedi, Catrin Morgan, Laurie Rigueros Springford, Mary Venn, Sarah Gentry, Chia Yew Kong, Jonathan Wan, Abhishek Chitnis, Nicholas Sim, Justine Davies, Alistair JM Reed, George Bethell, Michael Kelly, Alex Elizabeth Ward, Philip Stather, Shershah Assadullah, Helen Heneghan, Stephen Chapman, Talisa Ross, Renol M Koshy, Paul McEnhill, Alice Buchan, Syed Shumon, Conor Toale, Ewan Kennedy, John Hayes, Amrita Dhutia, Joseph Duncumb, Sarah Hudson-Phillips, Daniyal Jafree, Shujing Jane Lim, Richard Adams, Adam Gwozdz, Kirtan Patel, Olivia Cundy, Richard Moon, Syed Faaz Ashraf, and Claireaux, H
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Adult ,Male ,medicine.medical_specialty ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Randomized controlled trial ,law ,Medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,Digestive System Surgical Procedures ,Aged ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,Odds ratio ,Middle Aged ,Confidence interval ,Colorectal surgery ,Surgery ,Logistic Models ,030220 oncology & carcinogenesis ,Propensity score matching ,Female ,business ,Cohort study ,Abdominal surgery - Abstract
Background Significant safety concerns remain surrounding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) following gastrointestinal surgery, leading to wide variation in their use. This study aimed to determine the safety profile of NSAIDs after major gastrointestinal surgery. Methods Consecutive patients undergoing elective or emergency abdominal surgery with a minimum one-night stay during a 3-month study period were eligible for inclusion. The administration of any NSAID within 3 days following surgery was the main independent variable. The primary outcome measure was the 30-day postoperative major complication rate, as defined by the Clavien–Dindo classification (Clavien–Dindo III–V). Propensity matching with multivariable logistic regression was used to produce odds ratios (OR) and 95 % confidence intervals. Results From 9264 patients, 23.9 % (n = 2212) received postoperative NSAIDs. The overall major complication rate was 11.5 % (n = 1067). Following propensity matching and adjustment, use of NSAIDs were not significantly associated with any increase in major complications (OR 0.90, 0.60–1.34, p = 0.560). Conclusions Early use of postoperative NSAIDs was not associated with an increase in major complications following gastrointestinal surgery.
- Published
- 2020