1. Prognostic Role of a New Index Tested in European and Korean Advanced Biliary Tract Cancer Patients: the PECS Index
- Author
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Luca Faloppi, Hyungwoo Cho, Federico Nichetti, Francesco Leone, Giuseppe Aprile, Daniele Santini, Giulia Orsi, Mariaelena Casagrande, Mario Scartozzi, Jae Ho Jeong, Nicola Silvestris, Giovanni Brandi, Eleonora Lai, Stefania De Lorenzo, Changhoon Yoo, Filippo de Braud, Monica Niger, Elisabetta Fenocchio, Lorenzo Fornaro, Stefano Cascinu, Caterina Vivaldi, Massimo Di Maio, Giulia Rovesti, Enrico Vasile, Andrea Casadei-Gardini, Francesco Caputo, Massimo Aglietta, Andrea Palloni, Roberto Filippi, Nicoletta Pella, Rovesti, G., Leone, F., Brandi, G., Fornaro, L., Scartozzi, M., Niger, M., Yoo, C., Caputo, F., Filippi, R., Casagrande, M., Silvestris, N., Santini, D., Faloppi, L., Palloni, A., Aglietta, M., Vivaldi, C., Cho, H., Lai, E., Fenocchio, E., Nichetti, F., Pella, N., De Lorenzo, S., Di Maio, M., Vasile, E., de Braud, F., Jeong, J. H., Aprile, G., Orsi, G., Cascinu, S., Casadei-Gardini, A., Rovesti G., Leone F., Brandi G., Fornaro L., Scartozzi M., Niger M., Yoo C., Caputo F., Filippi R., Casagrande M., Silvestris N., Santini D., Faloppi L., Palloni A., Aglietta M., Vivaldi C., Cho H., Lai E., Fenocchio E., Nichetti F., Pella N., De Lorenzo S., Di Maio M., Vasile E., de Braud F., Jeong J.H., Aprile G., Orsi G., Cascinu S., and Casadei-Gardini A.
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medicine.medical_specialty ,Index (economics) ,Multivariate analysis ,Survival ,Prognosi ,Neutrophils ,medicine.medical_treatment ,Locally advanced ,Gastroenterology ,Prognostic index ,Biliary tract cancer ,Chemotherapy ,Cholangiocarcinoma ,Gallbladder cancer ,Prognosis ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Republic of Korea ,Medicine ,Humans ,Lymphocytes ,Survival analysis ,Retrospective Studies ,Inflammation ,business.industry ,Reproducibility of Results ,medicine.disease ,Biliary Tract Neoplasms ,Oncology ,030220 oncology & carcinogenesis ,Absolute neutrophil count ,030211 gastroenterology & hepatology ,business - Abstract
Background and Aim: The aim of the present study is to evaluate a new index (PECS (PsECogSii)index) influenced by PS ECOG and systemic immune-inflammation index (SII) in unresectable locally advanced or metastatic BTC patients treated with first-line chemotherapy. Methods: This multicenter, international, study was conducted on a training cohort of 130 patients and in three European and Korean validation cohorts The PECS index was calculated as ECOG × SII index (neutrophil count × platelet count/lymphocyte count). Event-time distributions were estimated using the Kaplan–Meier method and survival curves were compared using the log-rank test. Results: In the training cohort, the median overall survival (mOS) was 13.2months, 8.7months, and 3.8months for patients with PECS-0, PECS-1, and PECS-2, respectively (PECS-0: HR=1; PECS-1: HR 1.41; PECS-2: HR 3.23) (p 
- Published
- 2021