1. Dose selection for radioiodine therapy of borderline hyperthyroid patients according to thyroid uptake of 99mTc-pertechnetate: applicability to unifocal thyroid autonomy?
- Author
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Thomas Krause, Michael Wissmeyer, Samer Ezziddin, Holger Brockmann, Dirk von Mallek, Michael J. Reinhardt, A. Joe, Freimut D. Juengling, and Kim Biermann
- Subjects
Adult ,Male ,endocrine system ,endocrine system diseases ,Hyperthyroidism ,Sensitivity and Specificity ,Severity of Illness Index ,Iodine Radioisotopes ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Radionuclide Imaging ,Aged ,Sodium Pertechnetate Tc 99m ,Aged, 80 and over ,Thyroid uptake ,business.industry ,Thyroid ,Dose fractionation ,Reproducibility of Results ,Dose-Response Relationship, Radiation ,Radiotherapy Dosage ,Radioiodine therapy ,Nodule (medicine) ,General Medicine ,Middle Aged ,Prognosis ,Dose–response relationship ,Treatment Outcome ,medicine.anatomical_structure ,Absorbed dose ,Feasibility Studies ,Female ,Dose Fractionation, Radiation ,Radiopharmaceuticals ,medicine.symptom ,business ,Nuclear medicine ,Dose selection - Abstract
PURPOSE: The aim of this study was to evaluate the feasibility of applying a previously described dose strategy based on (99m)Tc-pertechnetate thyroid uptake under thyrotropin suppression (TcTU(s)) to radioiodine therapy for unifocal thyroid autonomy. METHODS: A total of 425 consecutive patients (302 females, 123 males; age 63.1+/-10.3 years) with unifocal thyroid autonomy were treated at three different centres with (131)I, using Marinelli's formula for calculation of three different absorbed dose schedules: 100-300 Gy to the total thyroid volume according to the pre-treatment TcTU(s) (n=146), 300 Gy to the nodule volume (n=137) and 400 Gy to the nodule volume (n=142). RESULTS: Successful elimination of functional thyroid autonomy with either euthyroidism or hypothyroidism occurred at a mean of 12 months after radioiodine therapy in 94.5% of patients receiving 100-300 Gy to the thyroid volume, in 89.8% of patients receiving 300 Gy to the nodule volume and in 94.4% receiving 400 Gy to the nodule volume. Reduction in thyroid volume was highest for the 100-300 Gy per thyroid and 400 Gy per nodule strategies (36+/-19% and 38+/-20%, respectively) and significantly lower for the 300 Gy per nodule strategy (28+/-16%; p
- Published
- 2006
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