27 results on '"EBER E"'
Search Results
2. Rehabilitation
- Author
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von Mutius, E, Gappa, M, Eber, E, Frey, U, von Mutius, E ( E ), Gappa, M ( M ), Eber, E ( E ), Frey, U ( U ), Jung, A, Spindler, T, von Mutius, E, Gappa, M, Eber, E, Frey, U, von Mutius, E ( E ), Gappa, M ( M ), Eber, E ( E ), Frey, U ( U ), Jung, A, and Spindler, T
- Published
- 2013
3. Kindliche Lunge und körperliche Aktivität
- Author
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von Mutius, Erika, Gappa, Monika, Eber, Ernst, Frey, Urs, von Mutius, E ( Erika ), Gappa, M ( Monika ), Eber, E ( Ernst ), Frey, U ( Urs ), Kriemler, Susi, von Mutius, Erika, Gappa, Monika, Eber, Ernst, Frey, Urs, von Mutius, E ( Erika ), Gappa, M ( Monika ), Eber, E ( Ernst ), Frey, U ( Urs ), and Kriemler, Susi
- Published
- 2013
4. Management of patients with SARS-CoV-2 infections with focus on patients with chronic lung diseases (as of 10 January 2022) : Updated statement of the Austrian Society of Pneumology (ASP).
- Author
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Olschewski H, Eber E, Bucher B, Hackner K, Handzhiev S, Hoetzenecker K, Idzko M, Klepetko W, Kovacs G, Lamprecht B, Löffler-Ragg J, Meilinger M, Müller A, Prior C, Schindler O, Täubl H, Zacharasiewicz A, Zwick RH, Arns BM, Bolitschek J, Cima K, Gingrich E, Hochmair M, Horak F, Jaksch P, Kropfmüller R, Pfleger A, Puchner B, Puelacher C, Rodriguez P, Salzer HJF, Schenk P, Stelzmüller I, Strenger V, Urban M, Wagner M, Wimberger F, and Flick H
- Subjects
- Austria epidemiology, Child, Communicable Disease Control, Humans, SARS-CoV-2, Young Adult, COVID-19 epidemiology, Lung Diseases epidemiology, Lung Diseases therapy, Pulmonary Medicine
- Abstract
The Austrian Society of Pneumology (ASP) launched a first statement on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in May 2020, at a time when in Austria 285 people had died from this disease and vaccinations were not available. Lockdown and social distancing were the only available measures to prevent more infections and the breakdown of the health system. Meanwhile, in Austria over 13,000 patients have died in association with a SARS-CoV‑2 infection and coronavirus disease 2019 (COVID-19) was among the most common causes of death; however, SARS-CoV‑2 has been mutating all the time and currently, most patients have been affected by the delta variant where the vaccination is very effective but the omicron variant is rapidly rising and becoming predominant. Particularly in children and young adults, where the vaccination rate is low, the omicron variant is expected to spread very fast. This poses a particular threat to unvaccinated people who are at elevated risk of severe COVID-19 disease but also to people with an active vaccination. There are few publications that comprehensively addressed the special issues with SARS-CoV‑2 infection in patients with chronic lung diseases. These were the reasons for this updated statement. Pulmonologists care for many patients with an elevated risk of death in case of COVID-19 but also for patients that might be at an elevated risk of vaccination reactions or vaccination failure. In addition, lung function tests, bronchoscopy, respiratory physiotherapy and training therapy may put both patients and health professionals at an increased risk of infection. The working circles of the ASP have provided statements concerning these risks and how to avoid risks for the patients., (© 2022. The Author(s).)
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- 2022
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5. FDA warning montelukast 03.2020-Statement of the Austrian working group of pediatric pulmonology and allergology.
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Zschocke A, Horak F, Eber E, Frischer T, Simma B, Stetzl W, Riedler J, Szépfalusi Z, and Zacharasiewicz A
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- Acetates adverse effects, Austria, Child, Cyclopropanes, Humans, Infant, Sulfides, Anti-Asthmatic Agents adverse effects, Pulmonary Medicine, Quinolines adverse effects
- Abstract
Montelukast, a leukotriene receptor antagonist (LTRA) has been approved for use in Europe since 1998. Indications for use (from the age of 6 months) include mild to moderate asthma, seasonal allergic rhinitis with asthma, and the prevention of exercise-induced asthma episodes. The psychiatric side effects of montelukast have been known for the last 10 years; in the case of such symptoms benefits and risks should be considered. Due to potential life-threatening psychiatric adverse events, particularly suicide, a black box warning was issued. In this statement the Austrian working group of pediatric pulmonology and allergology advises that treatment with montelukast should be started only after critical evaluation. Treatment should be stopped on the occurrence of any neuropsychiatric side effects., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
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- 2022
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6. [Osteoporosis in pneumological diseases : Joint guideline of the Austrian Society for Bone and Mineral Research (ÖGKM) and the Austrian Society for Pneumology (ÖGP)].
- Author
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Muschitz C, Zwick RH, Haschka J, Dimai HP, Rauner M, Amrein K, Wakolbinger R, Jaksch P, Eber E, and Pietschmann P
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- Adolescent, Austria, Bone Density, Humans, Minerals, Osteoporosis, Osteoporotic Fractures, Pulmonary Medicine
- Abstract
Chronic inflammation induces proinflammatory cytokine cascades. In addition to systemic inflammation, hypoxemia, hypercapnia, a catabolic metabolism, gonadal or thyroid dysfunction, musculoskeletal dysfunction and inactivity as well as vitamin D deficiency contribute to an increased risk of fragility fractures. Iatrogenic causes of osteoporosis are long-term use of inhaled or systemic glucocorticoids (GC). Inhalative GC application in asthma is often indicated in childhood and adolescence, but interstitial lung diseases such as chronic organizing pneumonia, COPD, sarcoid or rheumatic diseases with lung involvement are also treated with inhalative or oral GC. In patients with cystic fibrosis, malabsorption in the context of pancreatic insufficiency, hypogonadism and chronic inflammation with increased bone resorption lead to a decrease in bone structure. After lung transplantation, immunosuppression with GC is a risk factor.The underlying pneumological diseases lead to a change in the trabecular and cortical bone microarchitecture and to a reduction in osteological formation and resorption markers. Hypercapnia, acidosis and vitamin D deficiency can accelerate this process and thus increase the individual risk of osteoporotic fragility fractures.A bone mineral density measurement with a T‑Score < -2.5 is a threshold value for the diagnosis of osteoporosis; in contrast the vast majority of all osteoporotic fractures occur with a T‑Score > -2.5. A history of low-trauma fracture indicates osteological therapy.All antiresorptive or anabolic drugs approved in Austria for the treatment of osteoporosis are also indicated for pneumological patients with an increased fragility fracture risk of bone fractures in accordance with the national reimbursement criteria.
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- 2021
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7. [Masterplan 2025 of the Austrian Society of Pneumology (ASP)-the expected burden and management of respiratory diseases in Austria].
- Author
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Studnicka M, Baumgartner B, Bolitschek J, Doberer D, Eber E, Eckmayr J, Hartl S, Hesse P, Jaksch P, Kink E, Kneussl M, Lamprecht B, Olschewski H, Pfleger A, Pohl W, Prior C, Puelacher C, Renner A, Steflitsch W, Stelzmüller I, Täubl H, Vonbank K, Wagner M, Wantke F, and Wass R
- Subjects
- Asthma therapy, Austria, Child, Cost of Illness, Humans, Pulmonary Disease, Chronic Obstructive, Societies, Medical, Lung Diseases, Obstructive therapy, Pulmonary Medicine standards, Pulmonary Medicine trends, Respiration Disorders therapy
- Abstract
Scientific Members of the Austrian Society of Pneumology describe the expected development in respiratory health and provide guidance towards patient-oriented and cost-efficient respiratory care in Austria.Methods: In November 2017, respiratory care providers (physicians, nurses, physiotherapists) together with patient's advocacy groups and experts in health development, collaborated in workshops on: respiratory health and the environment, bronchial asthma and allergy, COPD, pediatric respiratory disease, respiratory infections, sleep disorders, interventional pneumology, thoracic oncology and orphan diseases.Results: Respiratory disease is extremely prevalent and driven by ill-health behavior, i.e. cigarette smoking, over-eating and physical inactivity. For the majority of respiratory diseases increased prevalence, but decreased hospitalizations are expected.The following measures should be implemented to deal with future challenges:1. Screening and case-finding should be implemented for lung cancer and COPD.2. E-health solutions (telemedicine, personal apps) should be used to facilitate patient management.3. Regional differences in respiratory care should be reduced through E‑health and harmonization of health insurance benefits across Austria.4. Patient education and awareness, to reduce respiratory health illiteracy should be increased, which is essential for sleep disorders but relevant also for other respiratory diseases.5. Respiratory care should be inter-professional, provided via disease-specific boards beyond lung cancer (for ILDs, sleep, allergy)6. Programs for outpatient's pulmonary rehabilitation can have a major impact on respiratory health.7. Increased understanding of molecular pathways will drive personalized medicine, targeted therapy (for asthma, lung cancer) and subsequently health care costs.
- Published
- 2020
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8. Management of patients with SARS-CoV-2 infections and of patients with chronic lung diseases during the COVID-19 pandemic (as of 9 May 2020) : Statement of the Austrian Society of Pneumology (ASP).
- Author
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Flick H, Arns BM, Bolitschek J, Bucher B, Cima K, Gingrich E, Handzhiev S, Hochmair M, Horak F, Idzko M, Jaksch P, Kovacs G, Kropfmüller R, Lamprecht B, Löffler-Ragg J, Meilinger M, Olschewski H, Pfleger A, Puchner B, Puelacher C, Prior C, Rodriguez P, Salzer H, Schenk P, Schindler O, Stelzmüller I, Strenger V, Täubl H, Urban M, Wagner M, Wimberger F, Zacharasiewicz A, Zwick RH, and Eber E
- Subjects
- Adolescent, Adult, Austria, Betacoronavirus, COVID-19, Child, Chronic Disease, Humans, Lung Diseases therapy, Practice Guidelines as Topic, SARS-CoV-2, Coronavirus, Coronavirus Infections complications, Coronavirus Infections diagnosis, Coronavirus Infections therapy, Lung Diseases complications, Pandemics, Pneumonia, Viral complications, Pneumonia, Viral diagnosis, Pneumonia, Viral therapy, Pulmonary Medicine
- Abstract
The coronavirus disease 2019 (COVID-19) pandemic is currently a challenge worldwide. In Austria, a crisis within the healthcare system has so far been prevented. The treatment of patients with community-acquired pneumonia (CAP), including SARS-CoV‑2 infections, should continue to be based on evidence-based CAP guidelines during the pandemic; however, COVID-19 specific adjustments are useful. The treatment of patients with chronic lung diseases has to be adapted during the pandemic but must still be guaranteed.
- Published
- 2020
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9. [Statement of the Austrian Society of Pneumology (ASP)].
- Author
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Flick H, Arns BM, Bolitschek J, Bucher B, Cima K, Gingrich E, Handzhiev S, Hochmair M, Horak F, Idzko M, Jaksch P, Kovacs G, Kropfmüller R, Lamprecht B, Löffler-Ragg J, Meilinger M, Olschewski H, Pfleger A, Puchner B, Puelacher C, Prior C, Rodriguez P, Salzer H, Schenk P, Schindler O, Stelzmüller I, Strenger V, Täubl H, Urban M, Wagner M, Wimberger F, Zacharasiewicz A, Zwick RH, and Eber E
- Abstract
The COVID-19 pandemic is currently a challenge worldwide. In Austria, a crisis within the health care system has so far been avoided. The treatment of patients with community-acquired pneumonia (CAP), including SARS-CoV‑2 infections, should continue to be based on evidence-based CAP guidelines during the pandemic. However, COVID-19-specific adjustments are useful. The treatment of patients with chronic lung diseases must be adapted during the pandemic, but must still be guaranteed., (© The Author(s) 2020.)
- Published
- 2020
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10. Cystic fibrosis in Austria.
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Frischer T, Eber E, Ellemunter H, Zacharasiewicz A, Kaluza I, Riedler J, and Renner S
- Subjects
- Adolescent, Adult, Austria epidemiology, Burkholderia Infections complications, Burkholderia Infections epidemiology, Burkholderia Infections therapy, Child, Child, Preschool, Cystic Fibrosis Transmembrane Conductance Regulator genetics, Disease Progression, Female, Follow-Up Studies, Forced Expiratory Volume, Genotype, Humans, Infant, Male, Pseudomonas Infections complications, Pseudomonas Infections epidemiology, Pseudomonas Infections therapy, Registries, Young Adult, Cystic Fibrosis complications, Cystic Fibrosis epidemiology, Cystic Fibrosis genetics, Cystic Fibrosis pathology
- Abstract
Registry data for patients with cystic fibrosis (CF) are increasingly used to evaluate the natural history, for benchmarking of therapy and in order to identify eligible patients for clinical studies. So far, no data on frequency and clinical status of CF patients have been available for Austria on a national level. We collected data of CF patients treated 2014 in Austrian CF outpatient clinics by means of a European CF registry and on an individual search basis. A total of 773 CF patients with a median age of 18.9 years (SD 11.8 years) were seen in 13 centers (18-151 patients/center). Homozygous F508del mutation being the most common genotype was observed in 48.8% of patients. Mean age at diagnosis was 27 days. In 59% of all patients FEV1% predicted (Forced Exspiratory Volume in 1 second) was <80% and in 20% <50%. An average FEV1 predicted decline per year of 1.9% was observed between 6-18 years of age. Colonisation with Pseudomonas aeruginosa ranged between 12% and 69% in adult patients and in 0-16% in children with CF. Burkholderia cepacia complex species were present in a total of 29 samples (3.8%). Insulin therapy for diabetes was given in 14.5%. Liver involvement was reported in 36.3%. A wide variation of prescribed CF therapy was observed between centers. Data on CF patients living in Austria are now available and form a basis for clinical benchmarking as well as analyses from a public health perspective.
- Published
- 2017
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11. Diagnosis and management of asthma - Statement on the 2015 GINA Guidelines.
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Horak F, Doberer D, Eber E, Horak E, Pohl W, Riedler J, Szépfalusi Z, Wantke F, Zacharasiewicz A, and Studnicka M
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- Austria, Child, Preschool, Combined Modality Therapy standards, Drug Monitoring standards, Evidence-Based Medicine standards, Female, Humans, Immunotherapy standards, Infant, Infant, Newborn, Male, Medical History Taking standards, Pediatrics standards, Anti-Asthmatic Agents administration & dosage, Asthma diagnosis, Asthma therapy, Practice Guidelines as Topic, Pulmonary Medicine standards, Respiratory Function Tests standards
- Abstract
This statement was written by a group of pulmonologists and pediatric pulmonologists belonging to the corresponding professional associations ÖGP (Austrian Society for Pulmonology) and ÖGKJ (Austrian Society for pediatric and adolescent medicine) to provide a concise overview of the latest updates in the 2015 GINA Guidelines and to include aspects that are specific to Austria., Competing Interests: Conflict of interestF. Horak received lecture fees and congress-support from thermofisher, MEDA, HAL, Bencard, Allergopharma as well as sponsoring for organizing national seminars from HAL, Allergopharma, Bencard and Stallergenes. D. Doberer received financial support for the ASA-net (Austrian Severe Asthma Net) from Novartis. F. Wantke received lecture fees or congress-support from ALK, Thermofisher, Meda, Chiesi, Glaxo, Mundipharma and Novartis. M. Studnicka received lecture fees and congress support from Chiesi, Novartis, GSK, Boehringer-Ingelheim, Menarini, Astra-Zeneca. A. Zacharasiewicz received congress support from Chiesi, Gilead, AOP Orphan and Actavis and received lecture fees from Astra Zeneca and financial support and lecture fees for the ASA-net (Austrian Severe Asthma Net) from Novartis. W. Pohl has given presentations at symposia and/or served on scientific advisory boards sponsored by Almirall, Astra Zeneca, Boehringer Ingelheim, Chiesi, Mundipharma, Meda, Novartis, Teva. E. Eber received lecture fees and congress support from Actavis, AOP Orphan, AstraZeneca, Chiesi, Forest, Gilead, MSD, Novartis, and Pari. Z. Szepfalusi and E. Horak declare that they have no competing interests.
- Published
- 2016
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12. [Non-invasive and invasive out of hospital ventilation in chronic respiratory failure : Consensus report of the working group on ventilation and intensive care medicine of the Austrian Society of Pneumology].
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Schenk P, Eber E, Funk GC, Fritz W, Hartl S, Heininger P, Kink E, Kühteubl G, Oberwaldner B, Pachernigg U, Pfleger A, Schandl P, Schmidt I, and Stein M
- Subjects
- Austria, Chronic Disease, Critical Care standards, Evidence-Based Medicine, Ambulatory Care standards, Practice Guidelines as Topic, Pulmonary Medicine standards, Respiration, Artificial methods, Respiration, Artificial standards, Respiratory Insufficiency therapy
- Abstract
The current consensus report was compiled under the patronage of the Austrian Society of Pneumology (Österreichischen Gesellschaft für Pneumologie, ÖGP) with the intention of providing practical guidelines for out-of-hospital ventilation that are in accordance with specific Austrian framework parameters and legal foundations. The guidelines are oriented toward a 2004 consensus ÖGP recommendation concerning the setup of long-term ventilated patients and the 2010 German Respiratory Society S2 guidelines on noninvasive and invasive ventilation of chronic respiratory insufficiency, adapted to national experiences and updated according to recent literature. In 11 chapters, the initiation, adjustment, and monitoring of out-of-hospital ventilation is described, as is the technical equipment and airway access. Additionally, the different indications-such as chronic obstructive pulmonary diseases, thoracic restrictive and neuromuscular diseases, obesity hypoventilation syndrome, and pediatric diseases-are discussed. Furthermore, the respiratory physiotherapy of adults and children on invasive and noninvasive long-term ventilation is addressed in detail.
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- 2016
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13. [Infectious upper airway obstruction].
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Pfleger A and Eber E
- Abstract
Infectious diseases of the upper airway can lead to emergency situations with partial up to complete obstruction and respiratory insufficiency, especially in infants and toddlers. This necessitates a cool-headed and calm approach; however, at times a prompt intervention is required by the primary care physician. Important questions concerning patient history include the onset of symptoms, severity and duration of fever and for orientation possible previously known respiratory problems since birth or in the first weeks afterwards (e.g. congenital malformations of the larynx or trachea). The examination should begin by careful observation of the child's position of comfort and by noting all vital signs. A child with inspiratory or biphasic stridor at rest already has some degree of airway obstruction that can progress to complete obstruction over time. Systemic steroids and inhalation of nebulized epinephrine (adrenaline) are the best therapeutic options for viral laryngotracheobronchitis, which is the most common cause of acute stridor in childhood. Rare differential diagnoses, such as bacterial tracheitis, epiglottitis (supraglottitis), retropharyngeal and parapharyngeal infections necessitate disease-specific management., (© Springer-Verlag Wien 2015.)
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- 2015
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14. [Consensus statement on the evaluation and therapy of chronic cough in children].
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Zacharasiewicz A, Eber E, Riedler J, and Frischer T
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- Child, Child, Preschool, Chronic Disease, Cough physiopathology, Diagnosis, Differential, Humans, Infant, Infant, Newborn, Cough etiology, Cough therapy
- Abstract
Background: Currently no consensus guidelines on the evaluation and therapy of chronic cough in children have been published in German. Aim of this study was therefore, after a literature search on all relevant publications and guidelines concerning chronic cough in children, to publish a Statement of the Austrian Society of Pediatrics and The Austrian Society of Pneumology on the evaluation and therapy of chronic childhood cough and to publish a practice based approach. Aim was also to differentiate cough clearly from obstructive airway diseases and to summarize all relevant differential diagnosis using relevant patient history and clinical characteristics and give an overview of therapeutical approaches. The subjective component of cough and the difficulty to assess cough in an objective manner is discussed., Methods: A Cochrane and Medline Search were performed on all relevant literature until Mai 2013., Results: Chronic cough in children is defined as daily cough for more than 4 weeks. Duration of 3 to 8 weeks is sometimes called prolonged or sub-acute cough. Chronic cough may have specific cause and may be a symptom of an underling disease, which needs to be found and treated adequately. Unspecific cough may only be diagnosed after exclusion of all other causes. Any therapeutical approach needs to be re- evaluated and efficacy needs to be reviewed. Parental understanding of the etiology of cough in general and the influence of environmental exposures is essential for diagnosis., Conclusion: Chronic cough needs a detailed history and various differential diagnoses need to be taken in consideration. Children with persistent complaints without a proper diagnosis need to be seen in a center specialized in Pediatric Respiratory Medicine.
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- 2014
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15. Prospective evaluation of clinical scoring systems in infants with bronchiolitis admitted to the intensive care unit.
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Rödl S, Resch B, Hofer N, Marschitz I, Madler G, Eber E, and Zobel G
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- Bronchiolitis virology, Bronchopulmonary Dysplasia diagnosis, Bronchopulmonary Dysplasia virology, Gestational Age, Humans, Infant, Infant, Newborn, Infant, Premature, Prospective Studies, ROC Curve, Respiration, Artificial, Respiratory Syncytial Virus Infections virology, Sensitivity and Specificity, Time Factors, Birth Weight, Bronchiolitis pathology, Intensive Care Units, Pediatric standards, Respiratory Syncytial Virus Infections diagnosis, Respiratory Syncytial Viruses pathogenicity, Severity of Illness Index
- Abstract
The objective of this investigation was to compare different scoring systems to assess the severity of illness in infants with bronchiolitis admitted to a tertiary paediatric intensive care unit (PICU). Over an 18-year period (1990-2007), infants with bronchiolitis aged up to 12 months and admitted to the PICU were prospectively scored using the Pediatric Risk of Mortality III (PRISM III) score, the Organ System Failure (OSF) score and the Acute Physiologic Score for Children (APSC) within 24 h. Infants were compared as to whether or not bronchiolitis was associated with respiratory syncytial virus (RSV). There was no difference between 113 RSV-positive and 80 RSV-negative infants regarding gestational age, birth weight, rate of premature delivery or bronchopulmonary dysplasia (BPD). The PRISM III score differed significantly between RSV-positive and RSV-negative cases (3.27 ± 0.39 vs. 1.96 ± 0.44, p = 0.006), as did the OSF score (0.56 ± 0.05 vs. 0.35 ± 0.06, p = 0.049) and the APSC (5.16 ± 0.46 vs. 4.1 ± 0.53, p = 0.048). All scores were significantly higher in the subgroup with mechanical ventilation (p < 0.0001). The mean time of ventilation was significantly higher in the RSV-positive group compared to the RSV-negative group (6.39 ± 1.74 days vs. 2.4 ± 0.47 days, p < 0.001). Infants suffering from RSV-positive bronchiolitis had higher clinical scores corresponding with the severity of bronchiolitis.
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- 2012
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16. Molecular epidemiology of Pseudomonas aeruginosa in cystic fibrosis patients from Southeast Austria.
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Masoud-Landgraf L, Badura A, Eber E, Feierl G, Posch J, Zarfel G, Zach M, and Marth E
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- Austria epidemiology, Comorbidity, Humans, Prevalence, Pseudomonas aeruginosa classification, Cystic Fibrosis epidemiology, Cystic Fibrosis microbiology, Pseudomonas Infections epidemiology, Pseudomonas Infections microbiology, Pseudomonas aeruginosa genetics, Pseudomonas aeruginosa isolation & purification
- Abstract
Pseudomonas aeruginosa is the major pathogen in the cystic fibrosis (CF) lung, the predominant source of its acquisition, however, is under discussion. In order to study the molecular epidemiology, we evaluated 86 P. aeruginosa isolates from 43 CF patients from southeast Austria. The DiversiLab system was used to identify genetic relationships among the isolates. Antibiotic susceptibilities were tested with a broth microdilution method (Micronaut Merlin). A total of 39 unrelated P. aeruginosa genotypes were found of which 34 were unique to a single patient and one was unique to a sibling pair. We found low rates of resistance for β-lactams with resistance to piperacillin/tazobactam and ceftazidime ranging from 4 to 6%. Resistance rates for meropenem and ciprofloxacin were 11% and 15%, respectively. The prevalence of multidrug-resistant isolates was 2%. We conclude that the majority of P. aeruginosa isolates from CF patients originate from environmental sources and patient-to-patient spread is very uncommon in our centre.
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- 2012
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17. [The Fetal Tobacco Syndrome - A statement of the Austrian Societies for General- and Family Medicine (ÖGAM), Gynecology and Obstetrics (ÖGGG), Hygiene, Microbiology and Preventive Medicine (ÖGHMP), Pediatrics and Adolescence Medicine (ÖGKJ) as well as Pneumology (ÖGP)].
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Horak F Jr, Fazekas T, Zacharasiewicz A, Eber E, Kiss H, Lichtenschopf A, Neuberger M, Schmitzberger R, Simma B, Wilhelm-Mitteräcker A, and Riedler J
- Subjects
- Europe epidemiology, Evidence-Based Medicine, Female, Humans, Pregnancy, Prevalence, Risk Assessment, Risk Factors, Survival Analysis, Survival Rate, Syndrome, Fetal Diseases mortality, Pregnancy Complications mortality, Smoking mortality
- Abstract
Over more than 50 years, the nocuous effects of smoking in pregnancy on the fetus are well known. In the first years of science the focus was primarily on restricted fetal growth while in more recent years over 10.000 studies investigated the incomparably big sum of detrimental effects for the unborn's health. In this statement we want to present the recent scientific findings on this topic. The statement is aimed to show all doctors who treat pregnant women the present situation and evidence. In the beginning we give a short overview about the epidemiological situation in Europe. Then we present step by step the health effects with regards to pathophysiology and clinics. Furthermore the reader will learn about possibilities for smoking cessation in pregnancy. The problem of passive-smoking in pregnancy will be dealt with in a separate chapter. At present there is strong evidence that pregnant smoking has a detrimental effect on birth-weight, placenta-associated disease, stillbirth, sudden infant death syndrome (SIDS), childhood overweight, clefts, lung function, asthma, cardiovascular diseases and mental developmental disorders. These factors can be summarized by the term Fetal Tobacco Syndrome. There is supply for more studies for less investigated health effects. Pregnancy is a chance to stop smoking as most women show a high motivation in this period. Hence doctors of all disciplines should inform pregnant women about the detrimental effects of smoking on their unborn child and show them possibilities for smoking cessation.
- Published
- 2012
- Full Text
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18. [Guideline for the treatment of bronchial asthma in children and adolescents].
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Riedler J, Eber E, Frischer T, Götz M, Horak E, and Zach M
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- Adolescent, Adrenal Cortex Hormones therapeutic use, Adrenergic beta-Agonists therapeutic use, Asthma diagnosis, Child, Combined Modality Therapy, Drug Therapy, Combination, Evidence-Based Medicine, Follow-Up Studies, Humans, Leukotriene Antagonists therapeutic use, Patient Education as Topic, Randomized Controlled Trials as Topic, Anti-Asthmatic Agents therapeutic use, Asthma drug therapy
- Published
- 2008
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19. [Long-acting beta-2 agonists in pediatric asthma therapy--friend or foe].
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Kurz H, Eber E, Frischer T, Götz M, Horak E, Riedler J, Schmitzberger R, and Zach M
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- Austria, Delayed-Action Preparations, Risk Assessment methods, Risk Factors, Adrenergic beta-Agonists adverse effects, Adrenergic beta-Agonists therapeutic use, Anti-Asthmatic Agents adverse effects, Anti-Asthmatic Agents therapeutic use, Asthma drug therapy, Asthma mortality, Practice Guidelines as Topic
- Abstract
Recent publications suggest that long-acting beta-2 agonists (LABAs) increase the risk for death in asthma. The American Food and Drug Administration (FDA) published a relevant alert in 2005. In the currently valid Austrian consensus guidelines for drug therapy of bronchial asthma in children and adolescents, LABAs are only recommended as add-on therapy in those patients whose asthma is not sufficiently controlled by inhaled corticosteroids (ICS) alone. LABAs have no established role in earlier steps of the therapeutic algorithm; consequently, the prescription of ICS-LABA combinations for initial treatment of paediatric asthma is not supported by these consensus treatment guidelines.
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- 2006
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20. [Recurring obstructive bronchitis and asthmatic bronchitis in preschool aged children].
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Götz M, Eber E, Frischer T, Horak E, Kurz H, Riedler J, Schmitzberger R, and Zach M
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- Asthma complications, Austria, Bronchitis, Chronic complications, Child, Preschool, Humans, Pulmonary Disease, Chronic Obstructive etiology, Secondary Prevention, Asthma diagnosis, Asthma therapy, Bronchitis, Chronic diagnosis, Bronchitis, Chronic therapy, Practice Guidelines as Topic, Practice Patterns, Physicians' standards, Pulmonary Disease, Chronic Obstructive diagnosis, Pulmonary Disease, Chronic Obstructive therapy
- Published
- 2006
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21. Pneumonitis and pneumatoceles following accidental hydrocarbon aspiration in children.
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Thalhammer GH, Eber E, and Zach MS
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- Accidents, Home, Anti-Bacterial Agents administration & dosage, Child, Preschool, Humans, Infant, Male, Pneumonia drug therapy, Radiography, Steroids administration & dosage, Treatment Outcome, Hydrocarbons poisoning, Industrial Oils poisoning, Pneumonia chemically induced, Pneumonia diagnostic imaging
- Abstract
Accidental ingestion and aspiration of hydrocarbons in children are common. Among the various clinical and pathological manifestations of hydrocarbon (HC) poisoning, pneumonitis is the most significant and occurs in up to 40% of children, whereas formation of pneumatoceles is believed to be a rare event. We report two children with HC pneumonitis and pneumatoceles as a reversible complication after ingestion and aspiration of lamp oil with very low viscosity. Patient 1, a 21-month-old boy, started to cough and developed tachypnea, sternal retractions and mild cyanosis immediately after aspiration. Patient 2, a 24-month-old girl, was asymptomatic during the first days after the accident; subsequently, she started to cough and developed fever, dyspnea and chest pain. Chest x-ray and computed tomography revealed multiple patchy infiltrates in both cases; after several days, these confluent infiltrates developed into pneumatoceles. Both children were treated with antibiotics and steroids. They recovered within three and four weeks, respectively, with complete remission of the radiologic abnormalities and had an uneventful follow-up after discharge.
- Published
- 2005
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22. [Consensus recommendations on drug treatment of bronchial asthma in children and adolescents. 1. Addendum (2003). Austrian Society for Pediatrics and Adolescent Medicine and Austrian Society for Lung Diseases and Tuberculosis].
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Eber E, Frischer T, Götz M, Horak E, Kurz H, Riedler J, Schmitzberger R, and Zach M
- Subjects
- Adolescent, Adrenal Cortex Hormones administration & dosage, Adrenal Cortex Hormones therapeutic use, Adrenergic beta-Agonists administration & dosage, Adrenergic beta-Agonists therapeutic use, Adult, Age Factors, Anti-Asthmatic Agents administration & dosage, Anti-Asthmatic Agents therapeutic use, Austria, Bronchodilator Agents administration & dosage, Bronchodilator Agents therapeutic use, Child, Drug Therapy, Combination, Humans, Leukotriene Antagonists administration & dosage, Leukotriene Antagonists therapeutic use, Practice Guidelines as Topic, Theophylline administration & dosage, Theophylline therapeutic use, Time Factors, Adolescent Medicine, Asthma drug therapy, Pediatrics, Pulmonary Medicine, Societies, Medical
- Published
- 2003
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23. [Consensus guidelines for drug therapy of bronchial asthma in children and adolescents. Austrian Society of Pediatrics and Adolescent Medicine and Austrian Society for Lung Diseases and Tuberculosis].
- Author
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Frischer T, Eber E, Eichler I, Horak E, Riedler J, Götz M, and Zach M
- Subjects
- Adolescent, Algorithms, Austria, Child, Humans, Severity of Illness Index, Anti-Asthmatic Agents therapeutic use, Asthma diagnosis, Asthma drug therapy
- Published
- 1999
24. Molecular and clinical findings in Austrian cystic fibrosis patients with mutations in exon 11 of the CFTR gene.
- Author
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Greil I, Wagner K, Eber E, Zach M, and Rosenkranz W
- Subjects
- Adolescent, Adult, Austria, Child, Child, Preschool, Chromosome Mapping, Cystic Fibrosis diagnosis, Cystic Fibrosis Transmembrane Conductance Regulator, Female, Gene Frequency, Homozygote, Humans, Infant, Male, Polymerase Chain Reaction, Retrospective Studies, Cystic Fibrosis genetics, Exons, Membrane Proteins genetics, Point Mutation
- Abstract
In order to determine the heterogeneity of mutations in exon 11 of the cystic fibrosis transmembrane conductance regular (CFTR) gene in Austrian cystic fibrosis (CF) patients, we analysed 207 non-delta F508 chromosomes by direct sequencing of PCR-amplified genomic DNA. A total of four previously described point mutations present on 14/207 (6.8%) non-delta F508 chromosomes were detected: G542X, G551D, R553X, and R553Q. The second CF mutation was delta F508 in most patients, W1282X (a nonsense mutation in exon 20) in one and a currently unknown non-delta F508 mutation in another case. One patient was documented to be homozygous for G542X. The proportion of non-delta F508 chromosomes among total CF chromosomes is 45% in Austria and 32% in the world population. In our population the mutations G542X, G551D, and R553X were found on 3.9% (1.7%), 1.9% (0.9%) and 0.5% (0.2%) of non-delta F508 chromosomes (of total CF chromosomes), respectively. The average worldwide frequencies of these mutations are higher: 7.1% (2.4%), 4.8% (1.6%), 2.1% (0.7%) of non-delta F508 chromosomes (of total CF chromosomes screened), respectively. A comparison of the allele frequencies in Austria with those detected in neighbouring countries reveals some notable differences. In a subsequent retrospective analysis we found that all nucleotide changes, identified by direct sequencing, can be detected by denaturing gradient gel electrophoresis (DGGE). The lack of any false positive or false negative result suggests that DGGE is a convenient and reliable screening method for point mutations.
- Published
- 1995
25. [Flexible fiberoptic bronchoscopy in pediatrics--an analysis of 420 examinations].
- Author
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Eber E and Zach M
- Subjects
- Adolescent, Adult, Airway Obstruction therapy, Child, Child, Preschool, Diagnosis, Differential, Equipment Design, Female, Humans, Infant, Infant, Newborn, Male, Respiratory Tract Diseases complications, Respiratory Tract Diseases therapy, Respiratory Tract Neoplasms complications, Respiratory Tract Neoplasms therapy, Tracheostomy instrumentation, Airway Obstruction etiology, Bronchoscopes, Fiber Optic Technology instrumentation, Respiratory Sounds etiology, Respiratory Tract Diseases diagnosis, Respiratory Tract Neoplasms diagnosis
- Abstract
Over a 4-year period we performed 420 endoscopic investigations in 262 patients (aged 1 day-26 yrs) under sedation and local anesthesia, using several different flexible instruments; repeat procedures were performed in 58 children. The most common indications for diagnostic endoscopy were tracheostomy evaluation (27.1%), non-specific chest x-ray changes (13.8%), stridor (12.4%), atelectasis (7.9%), and the sampling of airway secretions or cells by bronchoalveolar lavage (5.5%); indications for 17 therapeutic endoscopies (4%) included the removal of airway secretions and mucus plugs, and aid in difficult intubations. Bronchomalacia (46X), tracheomalacia (41X), obstructing granulation tissue (36X), and laryngomalacia (35X) were the most common diagnoses; in addition, subglottic stenosis was found in 13, a subglottic hemangioma in 5, vocal cord paralysis in 5 and an endobronchial foreign body in 5 children. Findings were normal in 39 (9.3%) cases. A relevant diagnosis was established on 73.7% of all investigations. The diagnostic yield was highest in patients with stridor, persistent wheezing, atelectasis, non-specific chest x-ray changes, and in patients with a tracheostomy. The success rate of therapeutic procedures was 70.6%. Minor complications occurred in altogether 4.3% of cases; all were completely and rapidly reversible. Flexible fiberoptic bronchoscopy is a safe and valuable diagnostic and therapeutic tool for the management of infants and children with respiratory problems.
- Published
- 1995
26. [Mucoviscidosis screening with immunoreactive trypsin].
- Author
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Eber E, Ellemunter H, Engele H, Götz M, Grünberger W, Haas J, Janisch H, Leodolter S, Litscher H, and Müller G
- Subjects
- Austria, Cystic Fibrosis diagnosis, Humans, Infant, Newborn, Predictive Value of Tests, Reference Values, Cystic Fibrosis prevention & control, Neonatal Screening, Radioimmunoassay, Trypsin blood
- Abstract
Up to now 49,116 immunoreactive trypsin (IRT) measurements have been carried out in Austrian newborns in the first week of life. Related to provisionally chosen cut-off points, 301 newborns (0.61%) showed an elevated IRT value; 253 of them were successfully recalled. According to a direct strategy, sweat tests were done without a second IRT measurement in 101 infants; eleven of them were identified as cystic fibrosis (CF) patients. In accordance with a 2-step strategy, 152 infants were reinvestigated by a second IRT determination. Twenty-eight of them again showed an elevated IRT value, as based on provisional, age-dependent reference values; seven were subsequently identified as CF patients by sweat testing. So far two false-negative findings were obtained on IRT screening: one child was later identified as having CF on the basis of typical clinical symptoms and a positive sweat test, the other patient presenting with meconium ileus showed a normal IRT value after surgery, but was subjected to a sweat test in view of the underlying condition. These preliminary results suggest a CF incidence of 1 to 2460 newborns in Austria. Hence, IRT screening appears to be a reliable method for identifying CF patients in the newborn period, thereby facilitating early treatment and genetic counselling.
- Published
- 1992
27. [Effectiveness and tolerance of aerosol disodium cromoglycate in children with bronchial asthma].
- Author
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Zarkovic J, Angermayr R, Covi B, Danhorn H, Eber E, Emhofer J, Hagel E, Hirschmann R, Klabuschnigg A, and Riedler J
- Subjects
- Aerosols, Airway Resistance drug effects, Child, Child, Preschool, Female, Humans, Male, Nebulizers and Vaporizers, Asthma drug therapy, Cromolyn Sodium administration & dosage
- Abstract
Thirteen centres studied the efficacy and safety of nebulized cromolyn solution in 53 asthmatic children (36 m., 17 f.; mean age 4.8 +/- 1.7 years). During a fiveweek treatment period a significant reduction of asthmatic symptoms was observed by investigators daily symptom scores, as assessed by the parents, also showed a significant improvement during treatment period. In addition, there was also a marked decrease in the use of other anti-asthmatic medication (beta 2-sympathomimetics, theophylline and antihistamines). There were no side effects of nebulized cromolyn solution treatment.
- Published
- 1991
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