1. Linear neutralizing epitopes on the peplomer protein of coronaviruses
- Author
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Posthumus, W. P A, Meloen, R. H., Enjuanes, L., Correa, I., van Nieuwstadt, A. P., Koch, G., de Groot, R. J., Kusters, J. G., Luytjes, W., Spaan, W. J., van der Zeijst, B. A M, Lenstra, J. A., Posthumus, W. P A, Meloen, R. H., Enjuanes, L., Correa, I., van Nieuwstadt, A. P., Koch, G., de Groot, R. J., Kusters, J. G., Luytjes, W., Spaan, W. J., van der Zeijst, B. A M, and Lenstra, J. A.
- Abstract
Three years ago, we reported a comparison of the primary structures of the S peplomer proteins of three coronaviruses - mouse hepatitis virus (MHV, strain A59), infectious bronchitis virus (IBV, strain M41), and feline infectious peritonitis virus (FIPV, strain 79-1146) - which represent the three antigenic clusters in the Coronavirus family (De Groot et al., 1987a, b). A periodicity in the C-terminal part of the S sequence indicated the presence of a coiled-coil structure, which forms the stalk of the peplomer. The nonconserved N-terminal sequence probably forms the bulbous part of the peplomer.
- Published
- 1990