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Initially our method of the decomposition of charge state distributions of biopolymer ions was designed to estimate the probabilities of the retention of charges by biopolymer ionogenic groups without distinction of different charge carriers (proton, alkali metal ions, or other ions). The analysis of mass spectra of several peptides and proteins produced by electrospray ionization carried out on this basis made possible some conclusions about their ion structure and behavior inside the ion source. A generalization of the method for the case of multidimensional charge state distributions corresponding to the retention of various charge carriers by ions of biomolecules is described. Hopefully, this will make possible gaining more substantial information concerning the structure and behavior of biomolecule ions in solutions and under electrospray conditions, which can be important for various biological applications. Keywords: electrospray, biomolecules, multiply charged ions, charge state distribution, decomposition of distributions, ionogenic groups, probabilities of charge retention DOI: 10.1134/S1061934814130073, INTRODUCTION Electrospray ionization (ESI) [1, 2] is one of the most important methods of mild ionization and widely used for structural and conformational studies of biomolecules. The mass spectra of [...]

Byline: A. Molina (1), J. Gonzalez (1), M. LopezaTenes (1) Abstract: In this paper we have obtained the general analytical equations corresponding to the response of complicated charge transfer processes with coupled homogeneous chemical reactions in cyclic chronopotentiometry by applying the superposition principle. The analysis of different cycles of this response can be used to obtain accurate and contrasted values of kinetic parameters in each complex reaction scheme analysed. These parameters are of great interest for the chemist and the biochemist. These equations are also applicable to cyclic derivative chronopotentiometry which is a very useful method since the response is obtained with peaks in a similar way to cyclic voltammetry but its mathematical treatment is simpler. Author Affiliation: (1) Departamento de QuimicaaFisica, Universidad de Murcia, Espinardo, 30100, Murcia, Spain Article History: Registration Date: 29/09/2004