7 results on '"Bonomo, S"'
Search Results
2. Late Quaternary high uplift rates in northeastern Sicily: evidence from calcareous nannofossils and benthic and planktonic foraminifera
- Author
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Enrico Di Stefano, F. Russo, Rodolfo Sprovieri, Mauro Agate, Sergio Bonomo, Alessandro Incarbona, Di Stefano, E., Agate, M., Incarbona, A., Russo, F., Sprovieri, R., and Bonomo, S.
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biology ,Pleistocene ,Outcrop ,Neotectonic ,Stratigraphy ,Paleontology ,Geology ,Nannofossil ,Foraminifera ,biology.organism_classification ,Oceanography ,Benthic zone ,Ostracod ,Sedimentology ,Quaternary ,Emiliania huxleyi - Abstract
The northeastern part of Sicily is characterized by intense seismic activity. Several systems of faults have been recognized in Pliocene and Pleistocene sediments in the area and, in fact, estimates of uplift rates are among the highest recorded in Sicily and south Italy. We examined calcareous nannofossil and benthic and planktonic foraminifera assemblages from pelitic sediments of the Contrada Zura section (Barcellona Pozzo di Gotto Basin, Furnari village, Messina). The occurrence of Emiliania huxleyi, a coccolithophore species which appeared in the oceanic record about 270,000 years ago, is witness to the uniqueness of this outcrop, while the planktonic/benthic foraminifera ratio indicates a deep (slope) environment, in agreement with previous observations on macrobenthic and ostracod paleo-communities. Independently from the numerical estimate of the paleo-depth, there is little doubt that the occurrence of E. huxleyi in such sediments might be explained by exceptional uplift rates. Since resulting uplift rate estimates, between 3.2 and 5.5 mm/year, exceeded by far the regional, longer-term, vertical tectonic motion, we argue that a major contribution of coseismic displacement along active faults occurred in the Furnari area.
- Published
- 2012
3. Bile duct injuries: a contemporary survey of surgeon attitudes and experiences.
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Fletcher R, Cortina CS, Kornfield H, Varelas A, Li R, Veenstra B, and Bonomo S
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- Adult, Attitude of Health Personnel, Cholecystectomy, Laparoscopic methods, Cholecystectomy, Laparoscopic statistics & numerical data, Clinical Competence, Health Surveys, Humans, Incidence, Intraoperative Complications epidemiology, Intraoperative Complications etiology, Middle Aged, Bile Ducts injuries, Cholecystectomy, Laparoscopic adverse effects, Surgeons
- Abstract
Introduction: The incidence of bile duct injury (BDI) during laparoscopic cholecystectomy has not changed significantly in the past 2 decades despite increased operative experience and technical refinement. We sought to evaluate surgeon-specific factors associated with BDI and to assess how surgeons manage injuries., Methods: An online survey was sent to surgeons belonging to the Society of American Gastrointestinal and Endoscopic Surgeons via e-mail. Survey items included personal experience with BDI and how injuries were addressed. Statistical analysis was performed to identify factors associated with BDI., Results: The survey was sent to 3411 surgeons with 559 complete responses (16.5%). The mean age of respondents was 48.7 years with an average time in practice of 16.1 years. Most respondents (61.2%) had fellowship training. Forty-seven percent of surgeons surveyed experienced a BDI in their career with 17.1% of surgeons experiencing multiple BDIs. The majority of BDIs were identified in the operating room (64.5%); most injuries (66.9%) were repaired immediately. When repair was undertaken immediately, 77.4% of these repairs were performed in an open technique. A majority of surgeons (57.7%) felt that BDIs could theoretically be repaired laparoscopically and 25% of those surgeons had done so in practice. In multivariate logistic regression, any type of fellowship training was associated with a decreased risk of BDI (OR 0.51, 95% CI 0.34-0.76). Compared with those in non-academic practice, surgeons in academic practice were at a significantly decreased risk of having experienced a BDI (OR 0.62, 95% CI 0.42-0.92)., Conclusion: Nearly half of those surveyed, experienced a BDI during a laparoscopic cholecystectomy. Community and private practice setting were associated with an increased risk of BDI, while fellowship training and academic practice setting conferred a protective effect. A majority of surgeons felt that BDI could be repaired laparoscopically and 25% had done so in practice.
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- 2020
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4. Current practices in biliary surgery: Do we practice what we teach?
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Daly SC, Deziel DJ, Li X, Thaqi M, Millikan KW, Myers JA, Bonomo S, and Luu MB
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- Adult, Cholangiography statistics & numerical data, Cohort Studies, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Ultrasonography, Interventional statistics & numerical data, United States, Cholecystectomy, Laparoscopic methods, Practice Patterns, Physicians' statistics & numerical data
- Abstract
Introduction: Since the widespread adoption of laparoscopic techniques in biliary surgery, the incidence of bile duct injures (BDI) has not significantly declined despite increased operative experience and recognition of the critical view of safety (CVS) method for anatomic identification. We hypothesized that operative approaches in clinical practice may vary from well-described technical recommendations. The objective of this study was to access how practicing surgeons commonly identify anatomy during laparoscopic cholecystectomy (LC)., Methods: We performed a cohort study assessing practices in biliary surgery among current practicing surgeons. Surgeons belonging to the Midwest Surgical Association and the Society of American Gastrointestinal and Endoscopic Surgeons were surveyed. Items surveyed include preferred methods for cystic duct identification, recognition of the CVS, and use of intraoperative imaging., Results: In total, 374 of 849 surgeons responded. The CVS was not correctly identified by 75 % of surgeons descriptively and by 21 % of surgeons visually. 56 % of surgeons practiced the infundibular method for identification of the cystic duct; 27 % practiced the CVS method. Intraoperative cholangiography was used by 16 % and laparoscopic ultrasound by <1 %., Conclusion: A majority of surgeons preferably do not use the CVS method of identification during LC. A large percentage of practicing surgeons are unable to describe or visually identify the CVS. These results suggest an urgent need to reexamine the tenets of how LC is being taught and disseminated and present a clear target for improvement to reduce BDI.
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- 2016
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5. The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors.
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Bonomo S, Tosco P, Giorgis M, Lolli M, and Fruttero R
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- Dihydroorotate Dehydrogenase, Enzyme Inhibitors metabolism, Fluorine metabolism, Models, Molecular, Molecular Docking Simulation, Oxadiazoles chemistry, Oxidoreductases Acting on CH-CH Group Donors chemistry, Oxidoreductases Acting on CH-CH Group Donors metabolism, Pyrimidines biosynthesis, Pyrimidines chemistry, Enzyme Inhibitors chemistry, Fluorine chemistry, Oxidoreductases Acting on CH-CH Group Donors antagonists & inhibitors
- Abstract
Dihydroorotate dehydrogenase (DHODH) is an important drug target due to its prominent role in pyrimidine biosynthesis. Leflunomide and brequinar are two well-known DHODH inhibitors, which bind to the enzyme in the same pocket with different binding modes. We have recently realized a series of new inhibitors based on the 4-hydroxy-1,2,5-oxadiazole ring, whose activity profile was found to be closely dependent on the degree of fluorine substitution at the phenyl ring adjacent to the oxadiazole moiety; a positive influence of fluorine on the DHODH inhibitory potency was observed previously [Baumgartner et al. (2006) J Med Chem 49:1239-1247]. Potential energy surface scans showed that fluorine plays an important role in stabilizing the bioactive conformations; additionally, fluorine influences the balance between leflunomide-like and brequinar-like binding modes. These findings may serve as a guide to design more potent DHODH inhibitors.
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- 2013
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6. Estrogens need insulin-like growth factor I cooperation to exert their neuroprotective effects in post-menopausal women.
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Giunta M, Rigamonti AE, Bonomo SM, Gagliano MG, Müller EE, Scarpini E, Galimberti D, and Cella SG
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- Adult, Aged, Aged, 80 and over, Biomarkers metabolism, Estrogens metabolism, Estrogens physiology, Female, Humans, Insulin-Like Growth Factor I metabolism, Middle Aged, Neurodegenerative Diseases metabolism, Neuroprotective Agents metabolism, Postmenopause drug effects, Postmenopause metabolism, Young Adult, Estrogens therapeutic use, Hormone Replacement Therapy methods, Insulin-Like Growth Factor I physiology, Neurodegenerative Diseases prevention & control, Neuroprotective Agents therapeutic use, Postmenopause physiology
- Abstract
Background: The abrupt fall in estrogens levels during the menopausal transition may connote an hormonal state predisposing to neurodegenerative disorders, e.g. Alzheimer's disease (AD). Reportedly, the neurotrophic activity of estrogen involves an interaction with IGF-I., Aim: To evaluate the leukocyte gene expression of progesterone receptor (PR-A/B) and interleukin 6 (IL-6), two parameters under the control of estrogens and involved in the pathogenesis of AD., Subjects: The study was conducted in non-demented women divided into two groups according to their pre- or post-menopausal state; each group being further divided into two subgroups based on their circulating levels of IGF-I (normal or low). An additional sample of AD-affected women served as a comparison group., Results: Estrogens maintained their full activity only when IGF-I levels were in the range of normalcy. On the contrary, if the concentrations of one or both hormones were reduced, estrogens were not anymore capable to control the gene expression of PR-A/B or IL-6., Conclusions: Before administering hormone-based replacement therapy, characterization of the somatotropic function should be performed in the early phase of the menopause.
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- 2013
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7. Postlaparoscopic small bowel obstruction. Rethinking its management.
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Velasco JM, Vallina VL, Bonomo SR, and Hieken TJ
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- Adult, Aged, Female, Humans, Incidence, Intestinal Obstruction epidemiology, Male, Middle Aged, Prognosis, Reoperation, Retrospective Studies, Intestinal Obstruction etiology, Intestine, Small, Laparoscopy adverse effects
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Background: Patients with early postoperative small bowel obstruction (SBO) are usually managed nonoperatively with nasogastric suction, intravenous fluids, and observation. The majority of early postoperative SBO resolve without an operation., Methods: We performed a retrospective review of patients who had been diagnosed with postlaparoscopic SBO at three Chicago area teaching hospitals., Results: The patients were initially managed nonoperatively for up to 7 days. However, all of them subsequently required an operation. In every case, the postlaparoscopic SBO was caused by the small bowel being incarcerated in a peritoneal defect created either by trocar placement or peritoneal incision for herniorrhaphy., Conclusion: In contradistinction to the approach used for early SBO after laparotomy, prompt operative intervention for postlaparoscopic SBO is recommended.
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- 1998
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