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This book is a collection of high-quality peer-reviewed research papers presented at the Ninth International Conference on Cyber-Security, Privacy in Communication Networks (ICCS 2023) held at Cardiff School of Technologies, Cardiff Metropolitan University, Cardiff, UK, during 11–12 December 2023. This book presents recent innovations in the field of cyber-security and privacy in communication networks in addition to cutting edge research in the field of next-generation communication networks.

This book illustrates advancements in the sophisticated tools and techniques for discovering and designing new antiviral drugs, identifying approved drugs against new and emerging viruses through large-scale computational virtual screening or drug repurposing approaches, and their evaluation in various in vitro and in vivo models. The chapters also cover the challenges associated with the emergence of antiviral drug resistance and possible ways to counter them. It discusses bioinformatics tools and software and computational approaches for the discovery of antivirals. The books also outline approaches for designing broad-spectrum antivirals effective against viruses by epigenetic- and epitranscriptomic-targeted reprogramming. Further, it provides vital details on the procedures for drug applications, clinical trials, and their regulations. Finally, the book provides a comprehensive yet representative description of advances in antiviral research protocols and methodologies suitablefor antiviral researchers at all career stages, including graduate and postgraduate students and policy-makers. ​

This volume offers insights into human challenge studies, where adult volunteers are deliberately infected with a pathogen of interest. These studies can broaden our knowledge on infections that have a rather low natural infection rate, but still bear a great threat to global health. The authors also present instances, where no suitable animal model is available to help understand human immune responses to a specific pathogen. The recent SARS-CoV-2 pandemic is another example, where studies that are directly conducted in humans, could save valuable time. Human challenge studies can provide immunogenicity and early efficacy data for vaccine development. However, similar models could be used for studying a wide variety of medical treatments such as monoclonal antibodies, antibiotics, antivirals and bacteriophages. The chapters in this volume cover several pathogens, including viruses, bacteria and parasites, scientific and technical aspects as well as descriptions of regulatory, ethical and manufacturing requirements. The book serves as a valuable resource for scientists and clinicians working on human pathogens.

This book explains the translational aspects of ethnomedicinal plants of different geographical regions including India by explaining the medicinal properties against several diseases, genomic evolution in changing environments, metabolic profiling for biomarker discovery, the role of non-coding RNA in the synthesis of secondary metabolites, genome-wide transcriptome profiling, application of pluripotent stem cells for drug discovery, the importance of high-throughput omics, and genome-editing techniques. In addition, some of the chapters have been designed to describe the role of artificial intelligence, plant database, and network-based drug discovery to explore the medicinal importance of compounds as well as challenges and opportunities in drug discovery from ethnomedicinal plants. The book serves as a great source of information for the students, researchers/scientists of diverse fields such as pharmacognosy, plant physiologists, biotechnologists, and pharmaceutical scientists etc., working in the areas of phytotherapy from ethnomedicinal plants.

This series of books is a result of collaboration between the Chinese Academy of Sciences and relevant national departments. This book provides a comprehensive summary and analysis of the current state and future trends of e-Science in China, with a focus on strategic developments, application practices, and infrastructure construction. This book showcases the recent progress, achievements, and new situations in China's e-Science in the past two years, and offer detailed cases for reference. The content is rich and offers valuable insights for the future development of research informatization.

This edited volume presents perspectives from computer science, information theory, neuroscience and brain imaging, aesthetics, social sciences, psychiatry, and philosophy to answer frontier questions related to artificial intelligence and human experience. Can a machine think, believe, aspire and be purposeful as a human? What is the place in the machine world for hope, meaning and transformative enlightenment that inspires human existence? How, or are, the minds of machines different from that of humans and other species? These questions are responded to along with questions in the intersection of health, intelligence and the brain. It highlights the place of consciousness by attempting to respond to questions with the help of fundamental reflections on human existence, its life-purposes and machine intelligence. The volume is a must-read for interdisciplinary and multidisciplinary researchers in humanities and social sciences and philosophy of science who wish to understand the future of AI and society.

This handbook analyzes and develops methods and models to optimize solutions for energy access (for industry and the general world population alike) in terms of reliability and sustainability. With a focus on improving the performance of energy systems, it brings together state-of-the-art research on reliability enhancement, intelligent development, simulation and optimization, as well as sustainable development of energy systems. It helps energy stakeholders and professionals learn the methodologies needed to improve the reliability of energy supply-and-demand systems, achieve more efficient long-term operations, deal with uncertainties in energy systems, and reduce energy emissions.Highlighting novel models and their applications from leading experts in this important area, this book will appeal to researchers, students, and engineers in the various domains of smart energy systems and encourage them to pursue research and development in this exciting and highly relevant field.

This book contains best selected research papers presented at ICTCS 2021: Sixth International Conference on Information and Communication Technology for Competitive Strategies. The conference will be held at Jaipur, Rajasthan, India, during December 17–18, 2021. The book covers state-of-the-art as well as emerging topics pertaining to ICT and effective strategies for its implementation for engineering and managerial applications. This book contains papers mainly focused on ICT for computation, algorithms and data analytics, and IT security. The book is presented in two volumes.

Recent discoveries in microbiology are hard to grasp for those unfamiliar with scientific jargon, and the research data can be overwhelming even for those working in other scientific fields. This book aims to remedy this situation by presenting the most interesting findings and current trends in microbiology in an easy-to-read and understandable format. The first part tells the story of the beginnings of microbiology itself and introduces the reader to the founders of this fascinating research discipline. The second part focuses on communication between microorganisms and how they organize themselves into fascinating microbial cities called “biofilms”. The reader also learns how bacteria exchange genetic material - mechanisms that are the root of the emergence of multidrug-resistant superbugs, pathogens that pose a major burden to human health and our healthcare systems. The third part is devoted to the latest techniques being used by scientists to study, control, and manipulate microorganisms for our benefit. The final part links the first three parts together and highlights how infectious diseases, including coronaviruses, can be transmitted from animals to humans, how global warming is affecting emerging diseases, and provides information on the actions that need to be taken to get ahead of pathogenic microbes and future pandemics. This comprehensive, state-of-the-art book is intended for anyone interested in microbiology and epidemiology, from biology and biomedical students in schools and colleges, to patients suffering from infectious diseases who want to learn more about their condition. The concepts covered in this book contribute to UN Sustainable Development Goal 3: Health and Well-Being.

For the past 17 years, Pediatric Hypertension has served as the definitive reference text on hypertension in children and adolescents. Each edition has incorporated the latest research on the pathophysiology, clinical significance and management of hypertension in the young, and has incorporated the most current consensus guidelines on diagnosis and management. The years since publication of the fourth edition have seen further advances in the field that merit publication of an updated, expanded text, including: Analysis of the implications of updated hypertension guidelines on identification of youth at highest cardiovascular risk Additional data on the proximate effects of high blood pressure in children in adolescents Further understanding of the links between high blood pressure in youth and surrogate markers of adult cardiovascular disease The fifth edition is a readable, informative text that provides a comprehensive guide to the diagnosis, management and therapy of hypertension in children and adolescents, and presents new data that very clearly indicate that the origins of adult cardiovascular disease are rooted in pediatric hypertension. It will, as a result, be very important for therapeutic decisions and will also be highly relevant for those in internal medicine, who care for the millions of adults who have hypertension, cardiovascular disease and kidney disease. In this sense, the book fulfills the longstanding goal of showing that hypertension that begins in childhood is important to track, diagnose and treat, and that the present understanding of adult hypertension necessitates the study of blood pressure in youth. The fifth edition has a similar structural format to the prior editions and covers all aspects of pediatric hypertension, from basic science research to the most recent clinical information.

This encyclopedia covers the definitions, concepts, methods, theories, and application of evidence-based pharmaceutical public health and health services research. It highlights why and how this field has a significant impact on healthcare. The work aims to synthesize baseline knowledge as well as the latest and cutting-edge research-based information. The encyclopedia collates information on public health, health services research, evidence-based pharmacy practice and its impacts on patients, decision-makers and consumers. This reference work discusses all aspects of policy and practice decisions on medicines use, access and pharmacy services by covering broad aspects related to pharmacy practice, public health and health services research. The aim is to develop high-quality content, which will be a must-read and be used as a reference source at all pharmacy and medical schools in the world. The health services research investigates the impact of social factors, organizational policies, financing systems, medical technologies and personal influence on access, quality and cost of healthcare concerning the quality of life of the patients. This reference work fundamentally promotes the evidence-based evaluation of healthcare services and thus will improve the better access and delivery of healthcare services. Also, pharmacy, medical and health services students and researchers need a broad understanding of pharmaceutical public health, evidence-based approaches to delivering care, changing professional and patient behavior and undertaking research in these areas. In general, there is a need to build research capacity and capability in the pharmacy profession.EDITOR-IN-CHIEF:Professor Zaheer-Ud-Din Babar, University of HuddersfieldSECTION EDITORS:Filipa Alves da Costa, University of LisbonZubin Austin,University of TorontoDalia Dawood, National Institute for Health and Care ExcellenceAndy Gray, University of Kwa Zulu-NatalRachele Hendricks-Sturrup, Duke Margolis Center for Health PolicyJason Hsu, Taiwan Medical UniversityRabia Hussain, Universiti Sains MalaysiaChristine Y. Lu, Harvard Medical School and Harvard Pilgrim Health Care InstituteMohamed Izham Mohamed Ibrahim, Qatar UniversityPrasad Nishtala, University of BathDerek Charles Stewart, College of Pharmacy, Qatar UniversityFatima Suleman, University of Kwa Zulu-NatalZaheer-Ud-Din Babar, University of Huddersfield

This book analyzes the factors that have sparked pandemics over the past 2000 years, from the Antonine Plague to COVID-19.It is noteworthy that the frequency of pandemics has increased over the past 2000 years. The authors identify three main drivers for the development of pandemics: transportation, human development, and changes in natural ecosystems. It is important to note that with the advent of the industrial age, the length of time it takes for a pandemic to develop has decreased. COVID-19 is certainly not the last pandemic we will face. Therefore, it is of paramount importance to learn from the past 2000 years to help educate general community and public health officials about pandemic risks and help governments prepare for the next pandemic.The book is also very useful in low and middle-income countries where, in the last several decades, viruses with potential for pandemics have originated. It's comprehensiveness and didactic stylemake this book a valuable read for government health agencies, private organizations, health care professionals and students.

This book provides relevant theoretical frameworks and the latest empirical research findings in Operations Research (OR) and Management Science (MS) as applied to sustainability. Its goal is to identify and describe ways in which OR and MS have been applied to and influenced the development of sustainability. Many of the issues we face today stem from the interconnectivity of the economy, society, and the environment, and from how both the economy and society are affecting the environment. In response, there have been a range of local and global efforts to advance society without harming the natural environment. The book showcases how OR/MS can help to address these issues, specifically with regard to renewable energy, smart industry, smart cities, transportation, smart homes and devices, etc. This book is intended for professionals in the fields of energy, engineering, information science, mathematics and economics, and for researchers who wish to develop new skills in connection with sustainability, or whose work involves sustainability.

This textbook is an introductory guide to applied machine learning, specifically for biology students. It familiarizes biology students with the basics of modern computer science and mathematics and emphasizes the real-world applications of these subjects. The chapters give an overview of computer systems and programming languages to establish a basic understanding of the important concepts in computer systems. Readers are introduced to machine learning and artificial intelligence in the field of bioinformatics, connecting these applications to systems biology, biological data analysis and predictions, and healthcare diagnosis and treatment. This book offers a necessary foundation for more advanced computer-based technologies used in biology, employing case studies, real-world issues, and various examples to guide the reader from the basic prerequisites to machine learning and its applications.

This edited volume discusses the biopolitics and shock economy of COVID-19, emphasizing medical perspectives and the socioeconomic dynamics of the pandemic and the ensuing institutional responses. Written by an international, multidisciplinary group of academic and professional experts, chapters embrace a wide range of topics such as: medical perspectives on COVID-19; application of geospatial technology; infectivity, immunogenicity, and disease as important factors for adoption of relevant biopolitical measures; shock economy; COVID-19-induced transaction costs; social support and resilience of inhabitants of marginalized areas; business resilience factors; entrepreneurship; and digital transformation. Jointly addressing global examples of biopolitical governance and overarching macroeconomic effects of the pandemic, this volume will be of interest to academics across disciplines as well as policymakers and practitioners on the ground.

This book features selected papers presented at Third International Conference on International Conference on Information Management and Machine Intelligence (ICIMMI 2021) held at Poornima Institute of Engineering & Technology, Jaipur, Rajasthan, India during 23 – 24 December 2021. It covers a range of topics, including data analytics; AI; machine and deep learning; information management, security, processing techniques and interpretation; applications of artificial intelligence in soft computing and pattern recognition; cloud-based applications for machine learning; application of IoT in power distribution systems; as well as wireless sensor networks and adaptive wireless communication.

This book aims to serve the critical interests of the global community by supplying the most current knowledge and understanding of Covid-19 epidemiology, treatment, and prognoses. There was much uncertain and contradictory information published in the first year of the novel coronavirus. The dynamics of COVID-19 have now been realized, including the type of antibodies produced in infected patients and their limited lasting endurance. This book will set the record straight on the concept of “herd immunity” and explore the current vaccine trials taking place in different countries. This comprehensive book will illuminate recent advances regarding COVID-19 and offer a possible roadmap on how to move forward. Frontiers of COVID-19: A Pathophysiology and Epidemiology Roadmap of Novel Coronavirus Disease will be a vital and forward-looking guide for infectious disease clinicians, scientists and researchers, and students at the graduate level.

This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.

This book offers detailed insights into new methods for high-fidelity CFD, and their industrially relevant applications in aeronautics. It reports on the H2020 TILDA project, funded by the European Union in 2015-2018. The respective chapters demonstrate the potential of high-order methods for enabling more accurate predictions of non-linear, unsteady flows, ensuring enhanced reliability in CFD predictions. The book highlights industrially relevant findings and representative test cases on the development of high-order methods for unsteady turbulence simulations on unstructured grids; on the development of the LES/DNS methodology by means of multilevel, adaptive, fractal and similar approaches for applications on unstructured grids; and on leveraging existent large-scale HPC networks to facilitate the industrial applications of LES/DNS in daily practice. Furthermore, the book discusses multidisciplinary applications of high-order methods in the area of aero-acoustics. All in all, it offers timely insights into the application and performance of high-order methods for CFD, and an extensive reference guide for researchers, graduate students, and industrial engineers whose work involves CFD and turbulence modeling.

This book provides a detailed guide to the highly specialised but little known health information workforce - people who are health informaticians, digital health experts, and managers of health data, health information and health knowledge. It explains the basis of their unique functions within healthcare – their educational pathways and standards, professional qualifications and industry certifications, scholarly foundations and principles of good practice. It explores their challenges, including the rise of the health consumer movement, the drive to improve equity and quality in healthcare, new technologies such as artificial intelligence, and the COVID-19 infodemic. Case studies describe how practitioners in real-world roles around the world are addressing the digital transformation of health. The Health Information Workforce: Current and Future Developments offers insights into a skilled group of people who are essential for healthcare services to function, for care providers to practice at the top of their scope, for researchers to generate significant insights, and for care consumers to be empowered participants in health systems. This book offers new perspectives for anyone working or intending to work in the health sector. It is a critical resource for health workforce planners, employers and educators seeking guidance on the specialised capabilities needed for high performance in an increasingly information-intensive sector.

Global health has been challenged with the dawning of the era of the obesity epidemic, and thus as a consequence, strategies to reduce obesity have become public health priorities. According to the United Nations, obesity has been identified as a concern for achieving Sustainable Development Goals. Obesity is a serious health problem with an increased risk of several common diseases including diabetes, cardiovascular disease, and cancer. Although the fundamental cause of obesity and overweight is an imbalance between calorie intake and calorie expenditure, the underlying biochemical and metabolic processes that cause obesity are not fully understood.Two earlier volumes dedicated to the subject of obesity, published in the series “Advances in Biochemistry in Health and Disease” focused on the pathophysiology of obesity-induced health complications and the biochemistry of cardiovascular dysfunction in obesity. This book brings together contributions from international experts in the field to describe advancements on the mechanisms leading to development of obesity and related complications. There are 21 chapters in two different parts in this book, comprising of Part I: Pathophysiologic Mechanisms of Obesity (11 chapters) and Part II: Therapeutic Mechanisms of Obesity (10 chapters). This book will serve as a resource and be of interest to health professionals, medical students, fellows, residents and graduate students. It will also evoke innovative research and effective approaches for the prevention of obesity. This volume will accentuate that obesity is a major health hazard in its own right and that appropriate public health measures should be implemented to prevent or reduce or even reverse the impact of this global chronic disease.

This Open Access book gives a comprehensive account of both the history and current achievements of molecular beam research. In 1919, Otto Stern launched the revolutionary molecular beam technique. This technique made it possible to send atoms and molecules with well-defined momentum through vacuum and to measure with high accuracy the deflections they underwent when acted upon by transversal forces. These measurements revealed unforeseen quantum properties of nuclei, atoms, and molecules that became the basis for our current understanding of quantum matter. This volume shows that many key areas of modern physics and chemistry owe their beginnings to the seminal molecular beam work of Otto Stern and his school. Written by internationally recognized experts, the contributions in this volume will help experienced researchers and incoming graduate students alike to keep abreast of current developments in molecular beam research as well as to appreciate the history and evolution of this powerful method and the knowledge it reveals.

​This book is the outcome of a joint collaboration between East China Normal University and the University of Luxembourg, initiated by the Center of Ideas for the Basic Education of the Future (IBEF), and focuses on kindergartens in China from a cultural psychology perspective. By coupling young scholars from diverse cultural backgrounds as research tandems, this book uses an innovative methodological method to reveal a deeply immersing research perspective of the often complicated issues in the Chinese social reality, where long historical tradition and strong motivation for a “modernized” future are fused together and continuously evolve itself into a vibrant and intricate landscape. Meanings and values consciously or unconsciously promoted and conducted in the kindergarten are semiotic devices and they mediate children's and educator's daily behaviours and activities, which are constantly navigating among different social institutions and crossing the border of kindergarten. The book discusses the process of children's socialization in the kindergarten from different angles such as cultural objects, moral education, conflict negotiation, children's drawing analysis and the role of Lego in numeracy development. It also provides an overview of basic educational needs in Chinese kindergartens as well as three commentaries to provide background information and to add a reflective angle for the readers. By reading the book, readers will hopefully go through a constantly transforming process between familiarizing and de-familiarizing along with the research tandem and develop their own understanding of the complex landscape of the Chinese kindergarten and its children as developing subjects constantly living and transcending the context.

This book is a tribute to the scientific legacy of GianCarlo Ghirardi, who was one of the most influential scientists in the field of modern foundations of quantum theory. In this appraisal, contributions from friends, collaborators and colleagues reflect the influence of his world of thoughts on theory, experiments and philosophy, while also offering prospects for future research in the foundations of quantum physics. The themes of the contributions revolve around the physical reality of the wave function and its notorious collapse, randomness, relativity and experiments.

This handbook introduces the basic principles and fundamentals of cyber security towards establishing an understanding of how to protect computers from hackers and adversaries. The highly informative subject matter of this handbook, includes various concepts, models, and terminologies along with examples and illustrations to demonstrate substantial technical details of the field. It motivates the readers to exercise better protection and defense mechanisms to deal with attackers and mitigate the situation. This handbook also outlines some of the exciting areas of future research where the existing approaches can be implemented.Exponential increase in the use of computers as a means of storing and retrieving security-intensive information, requires placement of adequate security measures to safeguard the entire computing and communication scenario. With the advent of Internet and its underlying technologies, information security aspects are becoming a prime concern towards protecting the networks and the cyber ecosystem from variety of threats, which is illustrated in this handbook.This handbook primarily targets professionals in security, privacy and trust to use and improve the reliability of businesses in a distributed manner, as well as computer scientists and software developers, who are seeking to carry out research and develop software in information and cyber security. Researchers and advanced-level students in computer science will also benefit from this reference.

This revised and expanded second edition presents the most recent evidence-based facts on perioperative fluid management and discusses fluid management from basic sciences to clinical applications and the patients'outcomes.Recent advances in understanding the Revised Starling principle with new concepts in tissue perfusion and the most recent techniques of perioperative goal directed fluid management are described. The endothelial glycocalyx functions and the influence of fluid management on its integrity are covered in detail; moreover, the techniques for its protection are also discussed. The dilemma of perioperative use of hydroxyethyl starch solutions and the resurgence of interest in using human albumin as an alternative colloid is explored. The problems of using unbuffered solutions during the perioperative period and comparison between restrictive versus liberal fluid management are discussed in full. Lastly, case scenarios for every possible clinical situation describe the most up-to-date fluid management for the corresponding clinical problem. Perioperative Fluid Management, Second Edition is of interest to anesthesiologists and also intensivists.

This book discusses email spam detection and its challenges such as text classification and categorization. The book proposes an efficient spam detection technique that is a combination of Character Segmentation and Recognition and Classification (CSRC). The author describes how this can detect whether an email (text and image based) is a spam mail or not. The book presents four solutions: first, to extract the text character from the image by segmentation process which includes a combination of Discrete Wavelet Transform (DWT) and skew detection. Second, text characters are via text recognition and visual feature extraction approach which relies on contour analysis with improved Local Binary Pattern (LBP). Third, extracted text features are classified using improvised K-Nearest Neighbor search (KNN) and Support Vector Machine (SVM). Fourth, the performance of the proposed method is validated by the measure of metric named as sensitivity, specificity, precision, recall, F-measure, accuracy, error rate and correct rate. Presents solutions to email spam detection and discusses its challenges such as text classification and categorization;Analyzes the proposed techniques'performance using precision, F-measure, recall and accuracy;Evaluates the limitations of the proposed research thereby recommending future research.

Quantum mechanics has shown unprecedented success as a physical theory, but it has forced a new view on the description of physical reality. In recent years, important progress has been achieved both in the theory of open quantum systems and in the experimental realization and control of such systems. A great deal of the new results is concerned with the characterization and quantification of quantum memory effects. From this perspective, the 684. WE-Heraeus-Seminar has brought together scientists from different communities, both theoretical and experimental, sharing expertise on open quantum systems, as well as the commitment to the understanding of quantum mechanics. This book consists of many contributions addressing the diversified physics community interested in foundations of quantum mechanics and its applications and it reports about recent results in open quantum systems and their connection with the most advanced experiments testing quantum mechanics.

Microbial communities and their functions play a crucial role in the management of ecological, environmental and agricultural health on the Earth. Microorganisms are the key identified players for plant growth promotion, plant immunization, disease suppression, induced resistance and tolerance against stresses as the indicative parameters of improved crop productivity and sustainable soil health. Beneficial belowground microbial interactions with the rhizosphere help plants mitigate drought and salinity stresses and alleviate water stresses under the unfavorable environmental conditions in the native soils. Microorganisms that are inhabitants of such environmental conditions have potential solutions for them. There are potential microbial communities that can degrade xenobiotic compounds, pesticides and toxic industrial chemicals and help remediate even heavy metals, and thus they find enormous applications in environmental remediation. Microbes have developed intrinsic metabolic capabilities with specific metabolic networks while inhabiting under specific conditions for many generations and, so play a crucial role. The book Microbial Interventions in Agriculture and Environment is an effort to compile and present a great volume of authentic, high-quality, socially-viable, practical and implementable research and technological work on microbial implications. The whole content of the volume covers protocols, methodologies, applications, interactions, role and impact of research and development aspects on microbial interventions and technological outcomes in prospects of agricultural and environmental domain including crop production, plan-soil health management, food & nutrition, nutrient recycling, land reclamation, clean water systems and agro-waste management, biodegradation & bioremediation, biomass to bioenergy, sanitation and rural livelihood security. The covered topics and sub-topics of the microbial domain have high implications for the targeted and wide readership of researchers, students, faculty and scientists working on these areas along with the agri-activists, policymakers, environmentalists, advisors etc. in the Government, industries and non-government level for reference and knowledge generation.

This book discusses design techniques, layout details and measurements of several key analog building blocks that currently limit the performance of 5G and E-Band transceivers implemented in deep-scaled CMOS. The authors present recent developments in low-noise quadrature VCOs and tunable inductor-less frequency dividers. Moreover, the design of low-loss broadband transformer-based filters that realize inter-stage matching, power division/combining and impedance transformation is discussed in great detail. The design and measurements of a low-noise amplifier, a downconverter and a highly-linear power amplifier that leverage the proposed techniques are shown. All the prototypes were realized in advanced nanometer scaled CMOS technologies without RF thick to metal option.

This book is open access under a CC BY 4.0 license.​This handbook synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous medical, biopsychosocial, and early genomic models of health. Interdisciplinary chapters discuss major health concerns (diabetes, obesity), important less-studied conditions (hearing, kidney health), and large-scale issues (nutrition, adversity) from a lifespan viewpoint. In addition, chapters address methodological approaches and challenges by analyzing existing measures, studies, and surveys. The book concludes with the editors'research agenda that proposes priorities for future LCHD research and its application to health care practice and health policy.Topics featured in the Handbook include: The prenatal period and its effect on child obesity and metabolic outcomes.Pregnancy complications and their effect on women's cardiovascular health.A multi-level approach for obesity prevention in children.Application of the LCHD framework to autism spectrum disorder.Socioeconomic disadvantage and its influence on health development across the lifespan.The importance of nutrition to optimal health development across the lifespan.The Handbook of Life Course Health Development is a must-have resource for researchers, clinicians/professionals, and graduate students in developmental psychology/science; maternal and child health; social work; health economics; educational policy and politics; and medical law as well as many interrelated subdisciplines in psychology, medicine, public health,mental health, education, social welfare, economics, sociology, and law.

This volume presents one of the clinical foundations of vasculopathies: the biological markers and risk factors associated with cardiovascular disease. A detailed biological and clinical framework is provided as a prerequisite for adequate modeling. Chapter 1 presents cardiovascular risk factors and markers, where the search for new criteria is aimed at improving early detection of chronic diseases. The subsequent chapters focus on hypertension, which involves the kidney among other organs as well as many agents, hyperglycemia and diabetes, hyperlipidemias and obesity, and behavior. The last of these risk factors includes altered circadian rhythm, tobacco and alcohol consumption, physical inactivity, and diet. The volumes in this series present all of the data needed at various length scales for a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in anatomical conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning in quantitative terms.

This book systemically describes the mechanisms underlying the neural regulation of metabolism. Metabolic diseases, including obesity and its associated conditions, currently affect more than 500 million people worldwide. Recent research has shown that the neural regulation of metabolism is a central mechanism that controls metabolic status physiologically and pathophysiologically. The book first introduces the latest studies on the neural and cellular mechanisms of hypothalamic neurons, hypothalamic glial cells, neural circuitries, cellular signaling pathways, and synaptic plasticity in the control of appetite, body weight, feeding-related behaviors and metabolic disorders. It then summarizes the humoral mechanisms by which critical adipocyte-derived hormones and lipoprotein lipase regulate lipid and glucose metabolism, and examines the role of the hypothalamus-sympathetic nerve, a critical nerve pathway from CNS to peripheral nervous system (PNS), in the regulation of metabolism in multiple tissues/organs. Furthermore, the book discusses the functions of adipose tissue in energy metabolism. Lastly, it explores dietary interventions to treat neural diseases and some of the emerging technologies used to study the neural regulation of metabolism. Presenting cutting-edge developments in the neural regulation of metabolism, the book is a valuable reference resource for graduate students and researchers in the field of neuroscience and metabolism.

The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases.There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence boththe development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.

This book offers comprehensive coverage of the various aspects of personalized medicine as an original approach to classifying, understanding, treating and preventing disease based on individual biological differences. In the introductory section, it defines personalized medicine as a way toward new medical practices and addresses the question: What can personalized medicine offer citizens, medical professionals, reimbursement bodies and stakeholders? Subsequent chapters discuss the technological aspects of personalized medicine: data collection, comprehensive integration and handling of data, together with key enabling factors in developing the requisite technological support for personalized medicine. Lastly, the book explores the main issues shaping the implementation and development of personalized medicine – education, stakeholder participation, infrastructure, a new approach to the classification of disease and medical tests, regulatory frameworks, and new reimbursement models– together with ethical, legal and social issues. Ultimately, the book calls for interdisciplinarity and a radical change in the way we approach the health and wellbeing of individuals. Target groups are medical doctors and researchers in the field of biomedicine, as well as experts from the social sciences dealing with legal, economic and social aspects of health system issues in general. Though the book will primarily benefit these groups of professional experts, its content will also appeal to a far wider readership, as it deals with a paradigm shift in one of society's main pillars – the health system.

This book presents the most recent evidence-based facts on perioperative fluid management and discusses fluid management from basic sciences to clinical applications and the patients'outcomes. Recent advances in understanding the Revised Starling principle with new concepts in tissue perfusion and the most recent techniques of perioperative goal directed fluid management are described. The endothelial glycocalyx functions and the influence of fluid management on its integrity are covered in detail; moreover, the techniques for its protection are also discussed. The dilemma of perioperative use of hydroxyethyl starch solutions and the resurgence of interest in using human albumin as an alternative colloid is explored. The problems of using unbuffered solutions during the perioperative period and comparison between restrictive versus liberal fluid management are discussed in full. Perioperative Fluid Management will be of interest to anesthesiologists andalso intensivists.

From the reviews:'Astronomy and Astrophysics Abstracts has appeared in semi-annual volumes since 1969 and it has already become one of the fundamental publications in the fields of astronomy, astrophysics and neighbouring sciences. It is the most important English-language abstracting journal in the mentioned branches....The abstracts are classified under more than a hundred subject categories, thus permitting a quick survey of the whole extended material. The AAA is a valuable and important publication for all students and scientists working in the fields of astronomy and related scienes. As such it represents a necessary ingredient of any astronomical library all over the world.'Space Science Review1'Dividing the whole field plus related subjects into 108 categories, each work is numbered and most are accompanied by brief abstracts. Fairly comprehensive cross-referencing links relevant papers to more than one category, and exhaustive author and subject indices are to be found at the back, making the catalogues easy to use. The series appears to be so complete in its coverage and always less than a year out of date that I shall certainly have to make a little more space on those shelves for future volumes.'The Observatory Magazine2

This book had its genesIs In the frustrations of the editors in locating authoritative, up-to-date material for an interdisciplinary graduate course in mammary gland biology, lactation, and breast-feeding. As we turned to the original literature several reasons for the dearth of usable material became clear: (1) In the areas of mammary gland biology and physiology, particularly as they relate to the human, reviews simply have not kept up with current research, which has in the last two decades provided tremendous insight into the mechanisms of milk secretion and its control. (2) The lack of interest in human milk as infant food inhibited researchers until very recently from investigating human lactation. (3) Much of the relevant clinical information remains anecdotal with little scientific basis. In this book we have tried to present the fundamentals of mammary gland physiology at the organismic and cellular levels in a form readily understood by physicians, scientists, and other professionals. This basic information is accompanied by authoritative reviews of the nutritional and immunological properties of human milk and by clinically relevant chapters designed to help health care professionals deal with the medical problems of the breast-feeding mother and her infant. We have strived in these chapters for up-to-date, authoritative, but readable accounts. In so far as possible we have avoided areas where much of our understanding rests on speculation. In the clinical domain this was not always possible because of a lack of solid, scientific information about breast-feeding.

Striking a balance between the scientific and technological aspects of radiation curing, this work includes both a summary of current knowledge as well as many chapters which present the first comprehensive accounts of their subjects.

Masters Theses in the Pure and Applied Sciences was first conceived, published, and dis­ seminated by the Center for lnformation and Numerica/ Data Analysis and Synthesis (C/NDAS) • at Purdue University in 1957, starting its coverage of theses with the academic year 1955. Beginning with Volume 13, the printing and dissemination phases of the ac­ tivity were transferred to University Microfilms/Xerox of Ann Arbor, Michigan, with the thought that such an arrangement would be more beneficia! to the academic and general scientific and technical community. After fi ve years of this joint undertaking we had concluded that it was in the interest of ali concerned if the printing and distribution of the volume were handled by an international publishing house to assure improved service and broader dissemination. Hence, starting with Volume 18, Masters Theses in the Pure and App/ied Sciences has been disseminated on a worldwide basis by Plenum Publishing Corporation of New York, and in the same year the coverage was broadened to include Canadian universities. Ali back issues can also be ordered from Plenum. We have reported in Volume 21 (thesis year 1976) a total of 10,586 theses titles from 25 Canadian and 219 United States universities. We are sure that this broader base for theses titles reported will greatly enhance the value of this important annual reference work.

Yakir Aharonov is one of the leading figures in the foundations of quantum physics. His contributions range from the celebrated Aharonov-Bohm effect (1959), to the more recent theory of weak measurements (whose experimental confirmations were recently ranked as the two most important results of physics in 2011). This volume will contain 27 original articles, contributed by the most important names in quantum physics, in honor of Aharonov's 80-th birthday.Sections include'Quantum mechanics and reality,'with contributions from Nobel Laureates David Gross and Sir Anthony Leggett and Yakir Aharonov, S. Popescu and J. Tollaksen;'Building blocks of Nature'with contributions from Francois Englert (co-proposer of the scalar boson along with Peter Higgs);'Time and Cosmology'with contributions from Leonard Susskind, P.C.W. Davies and James Hartle;'Universe as a Wavefunction,'with contributions from Phil Pearle, Sean Carroll and David Albert;'Nonlocality,'with contributions from Nicolas Gisin, Daniel Rohrlich, Ray Chiao and Lev Vaidman; and finishing with multiple sections on weak values with contributions from A. Jordan, A. Botero, A.D. Parks, L. Johansen, F. Colombo, I. Sabadini, D.C. Struppa, M.V. Berry, B. Reznik, N. Turok, G.A.D. Briggs, Y. Gefen, P. Kwiat, and A. Pines, among others.