1. Quantitative assessment of cardiac 123 iodo-metaiodobenzylguanidine SPECT/CT in patients with arrhythmogenic right ventricular cardiomyopathy: Novel insight in disease monitoring.
- Author
-
Hagen JM, Zacherl MJ, Brendel M, Clauß S, Kääb S, Bartenstein P, Todica A, Böning G, and Fischer M
- Subjects
- Humans, Male, Female, Middle Aged, Adult, Aged, Heart diagnostic imaging, Echocardiography methods, Heart Ventricles diagnostic imaging, 3-Iodobenzylguanidine, Arrhythmogenic Right Ventricular Dysplasia diagnostic imaging, Single Photon Emission Computed Tomography Computed Tomography methods, Radiopharmaceuticals
- Abstract
Background: The heart-to-mediastinum ratio (H/M-Ratio) of
123 iodo-metaiodobenzylguanidine (123 I-MIBG) represents state-of-the-art assessment for sympathetic dysfunction in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aims to evaluate quantitative reconstruction of123 I-MIBG uptake and to demonstrate its correlation with echocardiographic parameters., Methods: Cardiac innervation was assessed in 23 patients diagnosed with definite ARVC or borderline ARVC and 12 patients with other cardiac disease presenting arrhythmia, using quantitative123 I-MIBG Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) imaging. Tracer uptake was evaluated in the left (LV) and right ventricle (RV) based on a CT scan after quantitative image reconstruction. The relationship between tracer uptake and echocardiographic parameter data was examined., Results: Absolute quantification of123 I-MIBG uptake in the LV and RV is feasible and correlates accurately with the gold standard H/M Ratio. When comparing sensitivity and specificity, the area under the curve (AUC) favors standardized uptake value (SUV) of the RV over the right-ventricle-to-mediastinum-ratio (RV/M-Ratio) for diagnosing ARVC. A reduced RV-SUV in patients with definite ARVC is associated with reduced RV function. RV polar maps revealed globally reduced123 I-MIBG uptake without segment-specific reduction in the RV., Conclusions: Quantitative123 I-MIBG SPECT in ARCV patients offers robust potential for clinical reporting and demonstrates a significant correlation with RV function. Segmental RV analysis needs to be evaluated in larger samples. In summary, cardiac123 I-MIBG imaging using SUV could facilitate image-guided therapy in patients diagnosed with ARVC., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)- Published
- 2024
- Full Text
- View/download PDF