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This book is the second in a two-volume set that offers comprehensive guidance on the diagnosis of bone tumors based on a modification of the WHO classification as well as management and follow-up. The emphasis throughout is on an integrated approach to diagnosis that highlights the role of clinical, radiologic, and pathologic correlation in reducing the possibility of diagnostic error. The diagnosis of bone tumors is difficult for a variety of reasons, including the numerous types of the tumors with variable subtypes, the protean radiologic manifestations and the variable pathologic findings case by case and even depending on the phase in each case, the presence of reactive changes to the tumor lesion, and overlapping findings between benign and malignant tumors. In addition, it is often more difficult by surgeon's inadequate biopsy. The author's aim is to offer the readers the best possible guidance in negotiating these difficulties. For each tumor types, a wide range of cases arepresented, from the common to the very rare. Appearances on the full range of imaging studies are illustrated, including conventional radiographs, bone scans, CT scan, MRI, and even PET/CT scans in malignant cases. Attention is also drawn to the role of long-term follow-up radiographs in ensuring correct diagnosis and management. This book will be an ideal resource for all practitioners and researchers who involved in bone tumor diagnosis and also management. Volume 2 covers osteoclastic giant cell-rich tumors, hematopoietic tumors, notochordal tumors, cysts and cyst-like lesions, vascular and neurogenic tumors, and tumors of other mesenchymal cells.

This comprehensive guide provides a uniquely practical, application-focused introduction to medical image analysis. This fully updated new edition has been enhanced with material on the latest developments in the field, whilst retaining the original focus on segmentation, classification and registration. Topics and features: presents learning objectives, exercises and concluding remarks in each chapter; describes a range of common imaging techniques, reconstruction techniques and image artifacts, and discusses the archival and transfer of images; reviews an expanded selection of techniques for image enhancement, feature detection, feature generation, segmentation, registration, and validation; examines analysis methods in view of image-based guidance in the operating room (NEW); discusses the use of deep convolutional networks for segmentation and labeling tasks (NEW); includes appendices on Markov random field optimization, variational calculus and principal component analysis.

This book is simultaneously a superb atlas and a detailed guide to all aspects of video capsule endoscopy. History, technique, performance, reading, indications, contraindications, outcomes, complications and alternative methods are described systematically by a large panel of experts. In addition, the full range of small bowel diseases, from the common to the rare, are described and illustrated using a unique and exhaustive collection of capsule endoscopy images that are accompanied by corresponding images of enteroscopy, surgery, radiology and histology whenever possible. The newest technology of colon capsule endoscopy is included and exciting potential future developments are also considered. This book will be indispensable for all who use the technique or are considering establishing a video capsule endoscopy service.

The three-volume set LNCS 8673, 8674, and 8675 constitutes the refereed proceedings of the 17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014, held in Boston, MA, USA, in September 2014. Based on rigorous peer reviews, the program committee carefully selected 253 revised papers from 862 submissions for presentation in three volumes. The 100 papers included in the second volume have been organized in the following topical sections: biophysical modeling and simulation; atlas-based transfer of boundary conditions for biomechanical simulation; temporal and motion modeling; computer-aided diagnosis; pediatric imaging; endoscopy; ultrasound imaging; machine learning; cardiovascular imaging; intervention planning and guidance; and brain.

This book constitutes the refereed proceedings of the 9th International Workshop on Augmented Environments for Computer-Assisted Interventions, held in conjunction with MICCAI 2014, in Boston, MA, USA in September 2014. The 15 revised full papers presented were carefully reviewed and selected from 23 submissions. The scope of the workshop spans the theoretical and practical aspects of augmented reality and visualization computer assisted intervention, interventional imaging, image-guided robotics, image-guided intervention, surgical planning and simulation, systematic extra- and intra-corporeal imaging modalities, general biological and neuroscience image computing, patient specific modeling, and medical image understanding.

This updated and refined new edition is the only book to provide a comprehensive approach to the intensive care of neurologically injured patients from the emergency room and ICU through the operating room and post-surgical period. It reviews neuroanatomy, neuroradiology, and neurophysiology, examines the neurological problems most frequently seen in intensive care, and describes the various types of neurosurgery. General issues are discussed, such as cardiac care, fluids and electrolytes, nutrition, and monitoring as well as more specific conditions and complications including elevated intracranial pressure, seizures, and altered mental states.

This book constitutes the refereed proceedings of two workshops MAIR/AE-CAI 2013, held in conjunction with MICCAI 2013, held in Nagoya, Japan, in September 2013. The 29 revised full papers presented were carefully reviewed and selected from 44 submissions. The papers cover a wide range of topics addressing the main research efforts in the fields of medical image formation, analysis and interpretation, augmented reality and visualization, computer assisted intervention, interventional imaging, image-guided robotics, image-guided intervention, surgical planning and simulation, systematic extra- and intra-corporeal imaging modalities, and general biological and neuroscience image computing.

The three-volume set LNCS 8149, 8150, and 8151 constitutes the refereed proceedings of the 16th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2013, held in Nagoya, Japan, in September 2013. Based on rigorous peer reviews, the program committee carefully selected 262 revised papers from 789 submissions for presentation in three volumes. The 95 papers included in the first volume have been organized in the following topical sections: physiological modeling and computer-assisted intervention; imaging, reconstruction, and enhancement; registration; machine learning, statistical modeling, and atlases; computer-aided diagnosis and imaging biomarkers; intraoperative guidance and robotics; microscope, optical imaging, and histology; cardiology, vasculatures and tubular structures; brain imaging and basic techniques; diffusion MRI; and brain segmentation and atlases.

The three-volume set LNCS 8149, 8150, and 8151 constitutes the refereed proceedings of the 16th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2013, held in Nagoya, Japan, in September 2013. Based on rigorous peer reviews, the program committee carefully selected 262 revised papers from 789 submissions for presentation in three volumes. The 86 papers included in the second volume have been organized in the following topical sections: registration and atlas construction; microscopy, histology, and computer-aided diagnosis; motion modeling and compensation; segmentation; machine learning, statistical modeling, and atlases; computer-aided diagnosis and imaging biomarkers; physiological modeling, simulation, and planning; microscope, optical imaging, and histology; cardiology; vasculatures and tubular structures; brain segmentation and atlases; and functional MRI and neuroscience applications.

The three-volume set LNCS 8149, 8150, and 8151 constitutes the refereed proceedings of the 16th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2013, held in Nagoya, Japan, in September 2013. Based on rigorous peer reviews, the program committee carefully selected 262 revised papers from 789 submissions for presentation in three volumes. The 81 papers included in the third volume have been organized in the following topical sections: image reconstruction and motion modeling; machine learning in medical image computing; imaging, reconstruction, and enhancement; segmentation; physiological modeling, simulation, and planning; intraoperative guidance and robotics; microscope, optical imaging, and histology; diffusion MRI; brain segmentation and atlases; and functional MRI and neuroscience applications.

Progess in specific computer-assisted techniques (digital imaging, computer-aided diagnosis, image-guided surgery, MEMS, etc.) combined with computer-assisted integration tools offers a valuable complement to or replacement for existing procedures in healthcare. Physicians are now employing PACS and telemedicine systems as enabling infrastructures to improve quality of and access to healthcare. Tools based on CAD and CAS facilitate completely new paths in patient care. To ensure that CARS tools benefit the patient, collaboration between various disciplines, specifically radiology, surgery, engineering, informatics, and healthcare management, is a critical factor. A multidisciplinary congress like CARS is a step in the desired direction of knowledge sharing and crossover education. It provides the necessary cooperative framework for advancing the development and application of modern computer-assisted technologies in healthcare.

This book constitutes the proceedings of the Third International Conference on Information Processing in Computer-Assisted Interventions IPCAI 2012, held in Pisa, Italy, on June 27, 2012. The 17 papers presented were carefully reviewed and selected from 31 submissions during two rounds of reviewing and improvement. The papers present novel technical concepts, clinical needs and applications as well as hardware, software and systems and their validation. The main technological focus is on patient-specific modeling and its use in interventions, image-guided and robotic surgery, real-time tracking and imaging.

The three-volume set LNCS 7510, 7511, and 7512 constitutes the refereed proceedings of the 15th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2012, held in Nice, France, in October 2012. Based on rigorous peer reviews, the program committee carefully selected 252 revised papers from 781 submissions for presentation in three volumes. The third volume includes 79 papers organized in topical sections on diffusion imaging: from acquisition to tractography; image acquisition, segmentation and recognition; image registration; neuroimage analysis; analysis of microscopic and optical images; image segmentation; diffusion weighted imaging; computer-aided diagnosis and planning; and microscopic image analysis.

The three-volume set LNCS 7510, 7511, and 7512 constitutes the refereed proceedings of the 15th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2012, held in Nice, France, in October 2012. Based on rigorous peer reviews, the program committee carefully selected 252 revised papers from 781 submissions for presentation in three volumes. The second volume includes 82 papers organized in topical sections on cardiovascular imaging: planning, intervention and simulation; image registration; neuroimage analysis; diffusion weighted imaging; image segmentation; computer-assisted interventions and robotics; and image registration: new methods and results.

This book presents a comprehensive overview of medical image analysis. Practical in approach, the text is uniquely structured by potential applications. Features: presents learning objectives, exercises and concluding remarks in each chapter, in addition to a glossary of abbreviations; describes a range of common imaging techniques, reconstruction techniques and image artefacts; discusses the archival and transfer of images, including the HL7 and DICOM standards; presents a selection of techniques for the enhancement of contrast and edges, for noise reduction and for edge-preserving smoothing; examines various feature detection and segmentation techniques, together with methods for computing a registration or normalisation transformation; explores object detection, as well as classification based on segment attributes such as shape and appearance; reviews the validation of an analysis method; includes appendices on Markov random field optimization, variational calculus and principal component analysis.

With the advances in image guided surgery for cancer treatment, the role of image segmentation and registration has become very critical. The central engine of any image guided surgery product is its ability to quantify the organ or segment the organ whether it is a magnetic resonance imaging (MRI) and computed tomography (CT), X-ray, PET, SPECT, Ultrasound, and Molecular imaging modality. Sophisticated segmentation algorithms can help the physicians delineate better the anatomical structures present in the input images, enhance the accuracy of medical diagnosis and facilitate the best treatment planning system designs. The focus of this book in towards the state of the art techniques in the area of image segmentation and registration.

Exciting new developments and applications of imaging techniques have emerged over the last few years, leading to many improvements in diagnosis and staging of urologic diseases. Refinements in the technology mean that imaging now is much more precise than even five years ago, and this has significantly enhanced its application within several key fields. As such, there are virtually no books currently available that cover the impact of these advances within urology leaving a major hole in the market. With its sound overview of the current state of affairs, and also its focus on highlighting future advances, this book would therefore find a significant audience within not only trainees, but also practicing clinicians too. Furthermore, the whole topic of ultrasonography is a relatively overlooked one, with very few modern books tackling any specific areas of the field. This book will be up-to-date and will pay attention to the unique applications of ultrasound within each discipline.

The two-volume set LNCS 5761 and LNCS 5762 constitute the refereed proceedings of the 12th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2009, held in London, UK, in September 2009. Based on rigorous peer reviews, the program committee carefully selected 259 revised papers from 804 submissions for presentation in two volumes. The second volume includes 134 papers divided in topical sections on shape modelling and analysis; motion analyysis, physical based modelling and image reconstruction; neuro, cell and multiscale image analysis; image analysis and computer aided diagnosis; and image segmentation and analysis.

The two-volume set LNCS 5761 and LNCS 5762 constitute the refereed proceedings of the 12th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2009, held in London, UK, in September 2009. Based on rigorous peer reviews, the program committee carefully selected 259 revised papers from 804 submissions for presentation in two volumes. The first volume includes 125 papers divided in topical sections on cardiovascular image guided intervention and robotics; surgical navigation and tissue interaction; intra-operative imaging and endoscopic navigation; motion modelling and image formation; image registration; modelling and segmentation; image segmentation and classification; segmentation and atlas based techniques; neuroimage analysis; surgical navigation and robotics; image registration; and neuroimage analysis: structure and function.

The 11th International Conference on Medical Imaging and Computer Assisted Intervention, MICCAI 2008, was held at the Helen and Martin Kimmel Center of New York University, New York City, USA on September 6–10, 2008. MICCAI is the premier international conference in this domain, with - depth papers on the multidisciplinary?elds of biomedical image computing and analysis, computer assisted intervention and medical robotics. The conference brings together biological scientists, clinicians, computer scientists, engineers, mathematicians, physicists and other interested researchers and o?ers them a forum to exchange ideas in these exciting and rapidly growing?elds. The conference is both very selective and very attractive: this year we - ceived a record number of 700 submissions from 34 countries and 6 continents, fromwhich258papers were selectedfor publication,whichcorrespondsto a s- cess rate of approximately 36%. Some interesting facts about the distribution of submitted and acceptedpapers are shown graphically at the end of this preface. The paper selection process this year was based on the following procedure, which included the introduction of several novelties over previous years. 1. A ProgramCommittee (PC) of 49 members was recruited by the Program Chairs,to getthenecessarybody ofexpertiseandgeographicalcoverage.All PC members agreed in advance to participate in the?nal paper selection process. 2. Key words grouped in 7 categories were used to describe the content of the submissions and the expertise of the reviewers.

The 11th International Conference on Medical Imaging and Computer Assisted Intervention, MICCAI 2008, was held at the Helen and Martin Kimmel Center of New York University, New York City, USA on September 6–10, 2008. MICCAI is the premier international conference in this domain, with - depth papers on the multidisciplinary?elds of biomedical image computing and analysis, computer assisted intervention and medical robotics. The conference brings together biological scientists, clinicians, computer scientists, engineers, mathematicians, physicists and other interested researchers and o?ers them a forum to exchange ideas in these exciting and rapidly growing?elds. The conference is both very selective and very attractive: this year we - ceived a record number of 700 submissions from 34 countries and 6 continents, fromwhich258papers were selectedfor publication,whichcorrespondsto a s- cess rate of approximately 36%. Some interesting facts about the distribution of submitted and acceptedpapers are shown graphically at the end of this preface. The paper selection process this year was based on the following procedure, which included the introduction of several novelties over previous years. 1. A ProgramCommittee (PC) of 49 members was recruited by the Program Chairs,to getthenecessarybody ofexpertiseandgeographicalcoverage.All PC members agreed in advance to participate in the?nal paper selection process. 2. Key words grouped in 7 categories were used to describe the content of the submissions and the expertise of the reviewers.

The 4th International Workshop on Medical Imaging and Augmented Reality, MIAR 2008, was held at the University of Tokyo, Tokyo, Japan during August 1–2, 2008. The goal of MIAR 2008 was to bring together researchersin medical imaging and intervention to present state-of-the-art developments in this ever-growing research area. Rapid technical advances in medical imaging, including its gr- ing application in drug/gene therapy and invasive/interventional procedures, have attracted signi?cant interest in the close integration of research in the life sciences, medicine, physical sciences, and engineering. Current research is also motivated by the fact that medical imaging is moving increasingly from a p- marily diagnostic modality towards a therapeutic and interventional aid, driven by the streamlining of diagnostic and therapeutic processes for human diseases by means of imaging modalities and robotic-assisted surgery. The impact of MIAR on these?elds increases each year, and the quality of submitted papers this yearwas veryimpressive. We received90 full submissions, which were subsequently reviewed by up to?ve reviewers. Reviewer a?liations were carefully checked against author a?liations to avoid con?icts of interest, and the review process was run as a double-blind process. A special procedure was also devised for papers from the universities of the organizers, upholding a double-blind review process for these papers. The MIAR 2008 Program C- mittee?nally accepted 44 full papers. For this workshop, we also included three papers from the invited speakers coveringregistration and segmentation, virtual reality, and perceptual docking for robotic control.

This title is part of a two-volume set that constitute the refereed proceedings of the 10th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2007. Coverage in this second volume includes computer assisted intervention and robotics, visualization and interaction, neuroscience image computing, computational anatomy, innovative clinical and biological applications, general biological imaging computing, computational physiology.

The 6th International Conference on Medical Imaging and Computer-Assisted Intervention,MICCAI2003,washeldinMontr´ eal,Qu´ ebec,CanadaattheF- rmont Queen Elizabeth Hotel during November 15–18, 2003. This was the?rst time the conference had been held in Canada. The proposal to host MICCAI 2003 originated from discussions within the Ontario Consortium for Ima- guided Therapy and Surgery, a multi-institutional research consortium that was supported by the Government of Ontario through the Ontario Ministry of E- erprise, Opportunity and Innovation. The objective of the conference was to o?er clinicians and scientists a - rum within which to exchange ideas in this exciting and rapidly growing?eld. MICCAI 2003 encompassed the state of the art in computer-assisted interv- tions, medical robotics, and medical-image processing, attracting experts from numerous multidisciplinary professions that included clinicians and surgeons, computer scientists, medical physicists, and mechanical, electrical and biome- cal engineers. The quality and quantity of submitted papers were most impressive. For MICCAI 2003 we received a record 499 full submissions and 100 short c- munications. All full submissions, of 8 pages each, were reviewed by up to 5 reviewers, and the 2-page contributions were assessed by a small subcomm- tee of the Scienti?c Review Committee. All reviews were then considered by the MICCAI 2003 Program Committee, resulting in the acceptance of 206 full papers and 25 short communications. The normal mode of presentation at MICCAI 2003 was as a poster; in addition, 49 papers were chosen for oral presentation.

The 6th International Conference on Medical Imaging and Computer-Assisted Intervention,MICCAI2003,washeldinMontr´ eal,Qu´ ebec,CanadaattheF- rmont Queen Elizabeth Hotel during November 15–18, 2003. This was the?rst time the conference had been held in Canada. The proposal to host MICCAI 2003 originated from discussions within the Ontario Consortium for Ima- guided Therapy and Surgery, a multi-institutional research consortium that was supported by the Government of Ontario through the Ontario Ministry of E- erprise, Opportunity and Innovation. The objective of the conference was to o?er clinicians and scientists a - rum within which to exchange ideas in this exciting and rapidly growing?eld. MICCAI 2003 encompassed the state of the art in computer-assisted interv- tions, medical robotics, and medical-image processing, attracting experts from numerous multidisciplinary professions that included clinicians and surgeons, computer scientists, medical physicists, and mechanical, electrical and biome- cal engineers. The quality and quantity of submitted papers were most impressive. For MICCAI 2003 we received a record 499 full submissions and 100 short c- munications. All full submissions, of 8 pages each, were reviewed by up to 5 reviewers, and the 2-page contributions were assessed by a small subcomm- tee of the Scienti?c Review Committee. All reviews were then considered by the MICCAI 2003 Program Committee, resulting in the acceptance of 206 full papers and 25 short communications. The normal mode of presentation at MICCAI 2003 was as a poster; in addition, 49 papers were chosen for oral presentation.

The fifth international Conference in Medical Image Computing and Computer Assisted Intervention (MICCAI 2002) was held in Tokyo from September 25th to 28th, 2002. This was the first time that the conference was held in Asia since its foundation in 1998. The objective of the conference is to offer clinicians and scientists the opportunity to collaboratively create and explore the new medical field. Specifically, MICCAI offers a forum for the discussion of the state of art in computer-assisted interentions, medical robotics, and image processing among experts from multi-disciplinary professions, including but not limited to clinical doctors, computer scientists, and mechanical and biomedical engineers. The expectations of society are very high; the advancement of medicine will depend on computer and device technology in coming decades, as they did in the last decades. We received 321 manuscripts, of which 41 were chosen for oral presentation and 143 for poster presentation. Each paper has been included in these proceedings in eight-page full paper format, without any differentiation between oral and poster papers. Adherence to this full paper format, along with the increased number of manuscripts, surpassing all our expectations, has led us to issue two proceedings volumes for the first time in MICCAI's history. Keeping to a single volume by assigning fewer pages to each paper was certainly an option for us considering our budget constraints. However, we decided to increase the volume to offer authors maximum opportunity to argue the state of art in their work and to initiate constructive discussions among the MICCAI audience.

The fifth international Conference in Medical Image Computing and Computer Assisted Intervention (MICCAI 2002) was held in Tokyo from September 25th to 28th, 2002. This was the first time that the conference was held in Asia since its foundation in 1998. The objective of the conference is to offer clinicians and scientists the opportunity to collaboratively create and explore the new medical field. Specifically, MICCAI offers a forum for the discussion of the state of art in computer-assisted interventions, medical robotics, and image processing among experts from multi-disciplinary professions, including but not limited to clinical doctors, computer scientists, and mechanical and biomedical engineers. The expectations of society are very high; the advancement of medicine will depend on computer and device technology in coming decades, as they did in the last decades. We received 321 manuscripts, of which 41 were chosen for oral presentation and 143 for poster presentation. Each paperhas been included in these proceedings in eight-page full paper format, without any differentiation between oral and poster papers. Adherence to this full paper format, along with the increased number of manuscripts, surpassing all our expectations, has led us to issue two proceedings volumes for the first time in MICCAI's history. Keeping to a single volume by assigning fewer pages to each paper was certainly an option for us considering our budget constraints. However, we decided to increase the volume to offer authors maximum opportunity to argue the state of art in their work and to initiate constructive discussions among the MICCAI audience.

In the four years of its existence, MICCAI has developed into the premier - nual conference on medical image computing and computer-assisted interv- tion. The single-track conference has an interdisciplinary character, bringing - getherresearchersfromboththenaturalsciencesandvariousmedicaldisciplines. It provides the international forum for developments concerning all aspects of medical image processing and visualization, image-guided and computer-aided techniques, and robot technology in medicine. The strong interest in MICCAI is con?rmed by the large number of subm- sions we received this year, which by far surpassed our expectations. The arrival of the shipload of papers just before the deadlines (one in the European and the otherin theAmericantime zone)wasa particularlyenjoyableexperience,aswas the whole procedure of preparing the scienti?c programme. Both the quantity and quality of the submissions allowed us to compose a volume of high quality papers, which we are sure will contribute to the further development of this exciting?eld of research. As for the hard numbers, in total 338 submissions were received. Next to full papers, short communications were solicited for works in progress,hardware prototypes, and clinical case studies. Long papers were reviewed by three or four reviewers and short papers by two or three reviewers. The?nal selection of papers was carried out by the Programme Board. Out of the 246 long papers, 36 were accepted for oral presentation and 100 as full posters. An additional 75 of the long papers, and 47 out of 92 short papers were accepted as short posters.