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This unique book covers the latest developments in coupling and decoupling of biomolecules containing functionalized carbohydrate components, being one of the first collections in this important area of applied medicinal chemistry.Connecting molecules, often referred as bio-conjugation, has become one of the most often performed procedures in modern medicinal chemistry. Sometimes, when the connected molecules are not useful anymore, they must be disconnected. The molecules that must be connected (coupled) may belong to both small and large molecules and include such constructs as glycoproteins, glycopeptides and glycans. In this work, more than 15 experts address a comprehensive range of potential and current uses of in vitro and in vivo bio-conjugation methodologies, leading to a variety of glycoconjugates. The analytical aspects of bio-conjugation are also here discussed. Medicinal and organic chemists from graduate level onwards will understand the appeal ofthis important book.

Armed–Disarmed Effects in Carbohydrate Chemistry: History, Synthetic and Mechanistic Studies, by Bert Fraser-Reid and J. Cristóbal López •A Survey of Ley's Reactivity Tuning in Oligosaccharide Synthesis, by Ana M. Gómez • “Active–Latent” Thioglycosyl Donors and Acceptors in Oligosaccharide Syntheses, by Tze Chieh Shiao and René Roy • Effect of Electron-Withdrawing Protecting Groups at Remote Positions of Donors on Glycosylation Stereochemistry, by Kwan Soo Kim and Dae-Hwan Suk • Influence of Protecting Groups on the Reactivity and Selectivity of Glycosylation: Chemistry of the 4,6-O-Benzylidene Protected Mannopyranosyl Donors and Related Species, by Sylvain Aubry, Kaname Sasaki, Indrajeet Sharma and David Crich • Superarmed and Superdisarmed Building Blocks in Expeditious Oligosaccharide Synthesis, by Hemali D. Premathilake and Alexei V. Demchenko•Programmable One-Pot Glycosylation, by Chung -Yi Wu and Chi -Huey Wong •Uronic Acids in Oligosaccharide and Glycoconjugate Synthesis, by Jeroen D. C. Codée, Alphert E. Christina, Marthe T. C. Walvoort, Herman S. Overkleeft and Gijsbert A. van der Marel