1. Radiotherapy-induced Cherenkov luminescence imaging in a human body phantom
- Author
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Petr Bruza, Jeremy Mengyu Jia, Shudong Jiang, Syed Rakin Ahmed, Brian W. Pogue, Sergei A. Vinogradov, Lesley A. Jarvis, and David J. Gladstone
- Subjects
Materials science ,medicine.medical_treatment ,Biomedical Engineering ,Signal-To-Noise Ratio ,Radiation ,01 natural sciences ,Imaging phantom ,Linear particle accelerator ,030218 nuclear medicine & medical imaging ,010309 optics ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Optics ,0103 physical sciences ,Image Processing, Computer-Assisted ,medicine ,Humans ,Image resolution ,Cherenkov radiation ,Radiotherapy ,Phantoms, Imaging ,business.industry ,Optical Imaging ,JBO Letters ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Radiation therapy ,Maximum intensity projection ,Luminescence ,business - Abstract
Radiation therapy produces Cherenkov optical emission in tissue, and this light can be utilized to activate molecular probes. The feasibility of sensing luminescence from a tissue molecular oxygen sensor from within a human body phantom was examined using the geometry of the axillary lymph node region. Detection of regions down to 30-mm deep was feasible with submillimeter spatial resolution with the total quantity of the phosphorescent sensor PtG4 near 1 nanomole. Radiation sheet scanning in an epi-illumination geometry provided optimal coverage, and maximum intensity projection images provided illustration of the concept. This work provides the preliminary information needed to attempt this type of imaging in vivo.
- Published
- 2018
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