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Study aims to adopt the cross-recurrence analysis for detection of coupling between the loops of sympathetic regulation of cardiovascular system. To test the applicability of the method and to set its parameters it was applied to the mathematical model of cardiovascular system that has a structure similar to the structure of the real system. To investigate whether the cross-recurrence analysis reflects the dynamics of autonomic control the authors conducted four numerical experiments with gradually decreasing activity of sympathetic regulation. No correlation was found between the results of cross-recurrence analysis and the coupling strengths.

We proposed the model of cardiovascular system which describes the sinus rhythm, autonomic regulation of heart and arterial vessels, baroreflex, arterial pressure and respiration process. The model included a self-oscillating loop of regulation of mean arterial pressure. It was shown that suggested model more accurately simulated the spectral and statistical characteristics of heart rate variability signal in comparison with the model proposed earlier by Seidel and Herzel.